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  • 1
    Online Resource
    Online Resource
    Interrelated Roles of Multiple Key Structure‐Directing Agents in Seed‐Mediated Growth of Monodisperse and Multibranched Au Nanoparticles
    Wiley ; 2023
    In:  ChemPhysChem Vol. 24, No. 13 ( 2023-07-03)
    Details
    In: ChemPhysChem, Wiley, Vol. 24, No. 13 ( 2023-07-03)
    Abstract: Detailed mechanistic investigations of the interrelated roles of multiple key structure‐directing agents in the growth solution of Au nanoparticles (AuNPs) is required for the optimization of synthetic protocols. Here, we report a robust seed‐mediated growth strategy for synthesizing multibranched NPs (MB‐AuNPs) with monodispersed size distribution, and investigate the roles of Ag ions and 4‐(2‐hydroxyethyl)piperazine‐1‐ethanesulfonic acid (HEPES) based on an overgrowth synthesis approach. The intertwining roles of Ag + , surface‐capping stabilizers, and reducing agents were elucidated, and used to control the morphology of MB‐AuNPs. The overgrowth of MB‐AuNPs involves two distinct underlying pathways, namely, directional and anisotropic growth of Au branches on specific facets of Au seeds as well as an aggregation and growth mechanism governed by HEPES. In addition to Ag ions and HEPES, morphology tunability can also be achieved by pre‐modification of the Au seeds with molecular probes. Optimized probe‐containing MB‐AuNPs prove to be excellent surface‐enhanced Raman scattering (SERS) substrates and nanozymes. Taken together, the results of this work reveal the mechanistic evolution of nanocrystal growth which should stimulate the development of new synthetic strategies, improve the capabilities of tuning the optical, catalytic, and electronic properties of NPs, and further advance their applications in biolabeling, imaging, biosensing, and therapy.
    Type of Medium: Online Resource
    ISSN: 1439-4235 , 1439-7641
    URL: Issue
    URL: Article
    DOI: 10.1002/cphc.v24.13
    DOI: 10.1002/cphc.202200842
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2025223-7
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  • 2
    Online Resource
    Online Resource
    Probing mid-infrared plasmon resonances in extended radial fractal structures
    Optica Publishing Group ; 2019
    In:  Optics Letters Vol. 44, No. 15 ( 2019-08-01), p. 3865-
    Details
    In: Optics Letters, Optica Publishing Group, Vol. 44, No. 15 ( 2019-08-01), p. 3865-
    Type of Medium: Online Resource
    ISSN: 0146-9592 , 1539-4794
    URL: Article
    DOI: 10.1364/OL.44.003865
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2019
    detail.hit.zdb_id: 243290-0
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  • 3
    Online Resource
    Online Resource
    Deep learning and artificial intelligence methods for Raman and surface-enhanced Raman scattering
    Elsevier BV ; 2020
    In:  TrAC Trends in Analytical Chemistry Vol. 124 ( 2020-03), p. 115796-
    Details
    In: TrAC Trends in Analytical Chemistry, Elsevier BV, Vol. 124 ( 2020-03), p. 115796-
    Type of Medium: Online Resource
    ISSN: 0165-9936
    URL: Article
    DOI: 10.1016/j.trac.2019.115796
    RVK:
    VG 2000
    RVK:
    VA 7720
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2014041-1
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  • 4
    Online Resource
    Online Resource
    A blueprint for performing SERS measurements in tissue with plasmonic nanofibers
    AIP Publishing ; 2020
    In:  The Journal of Chemical Physics Vol. 153, No. 12 ( 2020-09-28)
    Details
    In: The Journal of Chemical Physics, AIP Publishing, Vol. 153, No. 12 ( 2020-09-28)
    Abstract: Plasmonic nanostructures have found increasing utility due to the increased popularity that surface-enhanced Raman scattering (SERS) has achieved in recent years. SERS has been incorporated into an ever-growing list of applications, with bioanalytical and physiological analyses having emerged as two of the most popular. Thus far, the transition from SERS studies of cultured cells to SERS studies involving tissue has been gradual and limited. In most cases, SERS measurements in more intact tissue have involved nanoparticles distributed throughout the tissue or localized to specific regions via external functionalization. Performing highly localized measurements without the need for global nanoparticle uptake or specialized surface modifications would be advantageous to the expansion of SERS measurements in tissue. To this end, this work provides critical insight with supporting experimental evidence into performing SERS measurements with nanosensors inserted in tissues. We address two critical steps that are otherwise underappreciated when other approaches to performing SERS measurements in tissue are used. Specifically, we demonstrate two mechanical routes for controlled positioning and inserting the nanosensors into the tissue, and we discuss two means of focusing on the nanosensors both before and after they are inserted into the tissue. By examining the various combinations of these steps, we provide a blueprint for performing SERS measurements with nanosensors inserted in tissue. This blueprint could prove useful for the general development of SERS as a tool for bioanalytical and physiological studies and for more specialized techniques such as SERS-optophysiology.
    Type of Medium: Online Resource
    ISSN: 0021-9606 , 1089-7690
    URL: Article
    DOI: 10.1063/5.0024467
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 3113-6
    detail.hit.zdb_id: 1473050-9
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  • 5
    Online Resource
    Online Resource
    Evaluating nanoparticle localisation in glioblastoma multicellular tumour spheroids by surface enhanced Raman scattering
    Royal Society of Chemistry (RSC) ; 2023
    In:  The Analyst Vol. 148, No. 14 ( 2023), p. 3247-3256
    Details
    In: The Analyst, Royal Society of Chemistry (RSC), Vol. 148, No. 14 ( 2023), p. 3247-3256
    Abstract: Glioblastoma multiforme (GBM) is a particularly aggressive and high-grade brain cancer, with poor prognosis and life expectancy, in urgent need of novel therapies. These severe outcomes are compounded by the difficulty in distinguishing between cancerous and non-cancerous tissues using conventional imaging techniques. Metallic nanoparticles (NPs) are advantageous due to their diverse optical and physical properties, such as their targeting and imaging potential. In this work, the uptake, distribution, and location of silica coated gold nanoparticles (AuNP-SHINs) within multicellular tumour spheroids (MTS) derived from U87-MG glioblastoma cells was investigated by surface enhanced Raman scattering (SERS) optical mapping. MTS are three-dimensional in vitro tumour mimics that represent a tumour in vivo much more closely than that of a two-dimensional cell culture. By using AuNP-SHIN nanotags, it is possible to readily functionalise the inner gold surface with a Raman reporter, and the outer silica surface with an antibody for tumour specific targeting. The nanotags were designed to target the biomarker tenascin-C overexpressed in U87-MG glioblastoma cells. Immunochemistry indicated that tenascin-C was upregulated within the core of the MTS, however limitations such as NP size, quiescence, and hypoxia, restricted the penetration of the nanotags to the core and they remained in the outer proliferating cells of the spheroids. Previous examples of MTS studies using SERS demonstrated the incubation of NPs on a 2D monolayer of cells, with the subsequent formation of the MTS from these pre-incubated cells. Here, we focus on the localisation of the NPs after incubation into pre-formed MTS to establish a better understanding of targeting and NP uptake. Therefore, this work highlights the importance for the investigation and translation of NP uptake into these 3D in vitro models.
    Type of Medium: Online Resource
    ISSN: 0003-2654 , 1364-5528
    URL: Article
    DOI: 10.1039/D3AN00751K
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 1472713-4
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  • 6
    Online Resource
    Online Resource
    Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic Mice
    Rockefeller University Press ; 2001
    In:  The Journal of Cell Biology Vol. 152, No. 6 ( 2001-03-19), p. 1207-1218
    Details
    In: The Journal of Cell Biology, Rockefeller University Press, Vol. 152, No. 6 ( 2001-03-19), p. 1207-1218
    Abstract: Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystrophin glycoprotein complex and the α7β1 integrin. Defects in these linkage systems result in Duchenne muscular dystrophy (DMD), α2 laminin congenital muscular dystrophy, sarcoglycan-related muscular dystrophy, and α7 integrin congenital muscular dystrophy. Therefore, the molecular continuity between the extracellular matrix and cell cytoskeleton is essential for the structural and functional integrity of skeletal muscle. To test whether the α7β1 integrin can compensate for the absence of dystrophin, we expressed the rat α7 chain in mdx/utr−/− mice that lack both dystrophin and utrophin. These mice develop a severe muscular dystrophy highly akin to that in DMD, and they also die prematurely. Using the muscle creatine kinase promoter, expression of the α7BX2 integrin chain was increased 2.0–2.3-fold in mdx/utr−/− mice. Concomitant with the increase in the α7 chain, its heterodimeric partner, β1D, was also increased in the transgenic animals. Transgenic expression of the α7BX2 chain in the mdx/utr−/− mice extended their longevity by threefold, reduced kyphosis and the development of muscle disease, and maintained mobility and the structure of the neuromuscular junction. Thus, bolstering α7β1 integrin–mediated association of muscle cells with the extracellular matrix alleviates many of the symptoms of disease observed in mdx/utr−/− mice and compensates for the absence of the dystrophin- and utrophin-mediated linkage systems. This suggests that enhanced expression of the α7β1 integrin may provide a novel approach to treat DMD and other muscle diseases that arise due to defects in the dystrophin glycoprotein complex. A video that contrasts kyphosis, gait, joint contractures, and mobility in mdx/utr−/− and α7BX2-mdx/utr−/−mice can be accessed at http://www.jcb.org/cgi/content/full/152/6/1207.
    Type of Medium: Online Resource
    ISSN: 0021-9525 , 1540-8140
    URL: Article
    DOI: 10.1083/jcb.152.6.1207
    RVK:
    WA 15000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 2001
    detail.hit.zdb_id: 1421310-2
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Pushing the limits
    Springer Science and Business Media LLC ; 2022
    In:  Nature Reviews Chemistry Vol. 6, No. 12 ( 2022-11-17), p. 842-843
    Details
    In: Nature Reviews Chemistry, Springer Science and Business Media LLC, Vol. 6, No. 12 ( 2022-11-17), p. 842-843
    Type of Medium: Online Resource
    ISSN: 2397-3358
    URL: Article
    DOI: 10.1038/s41570-022-00444-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2886775-0
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  • 8
    Online Resource
    Online Resource
    Fabricating SERS-Active Nanofibers Covered with Au Nanoparticles for SERS Optophysiology
    The Electrochemical Society ; 2021
    In:  ECS Meeting Abstracts Vol. MA2021-01, No. 61 ( 2021-05-30), p. 1633-1633
    Details
    In: ECS Meeting Abstracts, The Electrochemical Society, Vol. MA2021-01, No. 61 ( 2021-05-30), p. 1633-1633
    Abstract: Nanofibers as biosensors have attracted great attention due to its facile removal from the biosystem after a period of intra- or extracellular measurements and site-specific measurement among others. The application of nanofibers covered with Au nanoparticles as SERS sensor circumvents the aggregation and accumulation of Au nanoparticles in vitro or in vivo , in addition to the greater Raman enhancement of signal than on planar surface. We report here on a strategy using block copolymer brush-layer templating and ligand exchange for fabricating highly reproducible and stable SERS-active nanofibers with tip diameters down to 60 nm and covered with well-dispersed and uniformly distributed branched AuNPs, which have intrinsic hotspots favoring inherently high plasmonic sensitivity. In addition, AuNPs with tunable morphology and adjacent spacing on the nanofibers can be adjusted using an in situ growth technique, thereby enhanced SERS sensitivity was obtained due to the asymmetric structure and coupling between the adjacent AuNPs. Tunable AuNP morphologies and hence the optical characteristics of the AuNPs on the nanofibers can be easily controlled by choice of experimental parameters, particularly the growth time. Besides, finite difference time domain (FDTD) simulations were performed to gain more insight into the electric-field enhancement of AuNPs on the high-curvature substrates. Furthermore, SERS application of these nanosensors in pH sensing and Hg 2+ detection is demonstrated here, offering appealing and promising candidates for real time monitoring of extra/intra-cellular species in vitro or in vivo . In addition to SERS sensing, these highly uniform nanosensors have other far-reaching implications, including medical diagnostics, therapeutics and so on. Figure 1
    Type of Medium: Online Resource
    ISSN: 2151-2043
    URL: Article
    DOI: 10.1149/MA2021-01611633mtgabs
    Language: Unknown
    Publisher: The Electrochemical Society
    Publication Date: 2021
    detail.hit.zdb_id: 2438749-6
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  • 9
    Online Resource
    Online Resource
    The Fundamentals of Real‐Time Surface Plasmon Resonance/Electrogenerated Chemiluminescence
    Wiley ; 2019
    In:  Angewandte Chemie Vol. 131, No. 50 ( 2019-12-09), p. 18370-18374
    Details
    In: Angewandte Chemie, Wiley, Vol. 131, No. 50 ( 2019-12-09), p. 18370-18374
    Abstract: We report the integration of surface plasmon resonance (SPR), cyclic voltammetry and electrochemiluminescence (ECL) responses to survey the interfacial adsorption and energy transfer processes involved in ECL on a plasmonic substrate. It was observed that a Tween 80/tripropylamine nonionic layer formed on the gold electrode of the SPR sensor, while enhancing the ECL emission process, affects the electron transfer process to the luminophore, Ru(bpy) 3 2+ , which in turn has an impact on the plasmon resonance. Concomitantly, the surface plasmon modulated the ECL intensity, which decreased by about 40 %, due to an interaction between the excited state of Ru(bpy) 3 2+ and the plasmon. This occurred only when the plasmon was excited, demonstrating that the optically excited surface plasmon leads to lower plasmon‐mediated luminescence and that the plasmon interacts with the excited state of Ru(bpy) 3 2+ within a very thin layer.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v131.50
    DOI: 10.1002/ange.201909806
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 10
    Online Resource
    Online Resource
    Surface-Enhanced Raman Scattering Optophysiology Nanofibers for the Detection of Heavy Metals in Single Breast Cancer Cells
    American Chemical Society (ACS) ; 2021
    In:  ACS Sensors Vol. 6, No. 4 ( 2021-04-23), p. 1649-1662
    Details
    In: ACS Sensors, American Chemical Society (ACS), Vol. 6, No. 4 ( 2021-04-23), p. 1649-1662
    Type of Medium: Online Resource
    ISSN: 2379-3694 , 2379-3694
    URL: Article
    URL: Article
    DOI: 10.1021/acssensors.1c00332
    DOI: 10.1021/acssensors.1c00332.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2021
    detail.hit.zdb_id: 2843497-3
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