In:
Pathobiology, S. Karger AG, Vol. 66, No. 5 ( 1998), p. 209-215
Kurzfassung:
In an attempt to clarify the biological nature of a human endogenous retrovirus (HERV), HERV-R, which is a single-copy type of HERVs and is conserved as a full-length viral sequence, the expression of HERV-R mRNA in normal autopsied systemic organs was examined by Northern blot analysis. The expression showed different levels among individuals, with the adrenal glands expressing the highest level of HERV-R among all organs tested, except for the placenta. In various adrenal tumors, HERV-R was expressed at high levels in all cortical adenomas but less so in pheochromocytomas. In situ hybridization revealed the expression of HERV-R to be localized in all layers of the adrenal cortex, but not in the medulla. This high-level expression of HERV-R in the adrenal cortex may possibly relate to differentiation and/or steroid production by adrenocortical cells.
Materialart:
Online-Ressource
ISSN:
1015-2008
,
1423-0291
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1998
ZDB Id:
1483541-1
SSG:
12
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