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  • 1
    Online Resource
    Online Resource
    Factors driving plastic-related behaviours: Towards reducing marine plastic waste in Hoi An, Vietnam
    Elsevier BV ; 2023
    In:  Journal of Cleaner Production Vol. 427 ( 2023-11), p. 139179-
    Details
    In: Journal of Cleaner Production, Elsevier BV, Vol. 427 ( 2023-11), p. 139179-
    Type of Medium: Online Resource
    ISSN: 0959-6526
    URL: Article
    DOI: 10.1016/j.jclepro.2023.139179
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1179393-4
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  • 2
    Online Resource
    Online Resource
    AGROBACTERIUM-MEDIATED TRANSFORMATION OF PANAX VIETNAMENSIS HA ET GRUSHV.
    Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications) ; 2018
    In:  Vietnam Journal of Biotechnology Vol. 15, No. 4 ( 2018-12-14), p. 641-650
    Details
    In: Vietnam Journal of Biotechnology, Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications), Vol. 15, No. 4 ( 2018-12-14), p. 641-650
    Abstract: In recent years, the Agrobacterium-mediated genetic transformation system has become the most useful method widely used for the introduction of foreign genes into plant cells followed by regeneration of genetically improved plants. Panax vietnamensis Ha et Grushv. is a highly valued medicinal plant native to Vietnam with limited area of distribution. This report illustrates the possibilities of biotechnology for genetic transformation aimed at establishing an effective production of secondary metabolites in P. vietnamensis. In the present investigation, 0.5 cm2 leaf blades, 1 cm long leaf petioles and 0.5 cm3 callus clusters were used for the hairy root induction. Results indicated that hairy roots were induced on P. vietnamensis callus clusters co-cultivated with Agrobacterium rhizogenes strain ATCC15834 at OD600 of 0.5 with an infection time of 20 min and a supplementation of 100 mM acetosyringone. PCR amplification of the DNA isolated from the resulting hairy roots was used to confirm the presence of rol genes. Compared to in vitro rhizome cultures, hairy root cultures appear to be potential for continuous production of valuable secondary metabolites with similar saponin profiles. The protocol described in this study is simple and rapid and therefore, can be used for large-scale experiments for the rapid production of valuable compounds.
    Type of Medium: Online Resource
    ISSN: 1811-4989 , 1811-4989
    URL: Article
    DOI: 10.15625/1811-4989/15/4/13404
    Language: Unknown
    Publisher: Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)
    Publication Date: 2018
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  • 3
    Online Resource
    Online Resource
    Evaluation of Drinking Water Quality in Schools in a District Area in Hanoi, Vietnam
    SAGE Publications ; 2020
    In:  Environmental Health Insights Vol. 14 ( 2020-01), p. 117863022095967-
    Details
    In: Environmental Health Insights, SAGE Publications, Vol. 14 ( 2020-01), p. 117863022095967-
    Abstract: Drinking water quality affects directly human health. Assessment and prevention of water-borne diseases are crucial for primary prevention, especially for children. Objective: The main aim of this study was to investigate the quality of drinking water from tap water in preschools and primary schools in a district area in Hanoi City, Vietnam. Methods: A cross-sectional study was performed from August to October 2019. Water samples from tap water of 154 schools in a district area of Hanoi were collected to determine the quality of drinking water. From each school, at least 2 bottles of water samples were collected on the basis of a standard operating procedure (SOP). Each water sample was analyzed for microbial and physicochemical parameters, including Color, Taste and Odor, Turbidity, pH, Nitrite, Nitrate, Ammonium, Total Iron, Permanganate, Chloride, Hardness, Total Manganese, Sulfate, Arsenic, Coliform, and E.coli, by analytical methods. The obtained values of each parameter were compared with the standard values set by WHO and National Technical Regulation on Domestic Water Quality of Vietnam. Results: All of the schools employed community water system as a main source for drinking water. The results showed that all tested samples were found to be within the standards for some physicochemical properties, including Color, Taste and Odor, Hardness, Chloride, Total Iron (Fe 2+ và Fe 3+ ), Total Manganese (Mn), Nitrate (NO 3 – ), Sulfate (SO 4 2– ), and Total Arsenic (As). On the other hand, some samples did not meet the allowable limits of the national standard, due to pH (3.9%), Turbidity (0.6%), Nitrite (3.2%), Permanganate (6.5%), and Ammonium (5.8%). Furthermore, the microbial data revealed that the substandard water samples from municipal water systems were contaminated by Coliform (9.7%) and/or E.coli (7.8%). Conclusions and recommendations: Contaminants such as bacterial and chemical agents in to drinking water could be occurred during transport, storage and handling before using by the consumer without regular surveillance. A periodic treatment procedure and monitoring system to keep the level of microbial and chemical contamination of drinking water in schools under control should be performed.
    Type of Medium: Online Resource
    ISSN: 1178-6302 , 1178-6302
    URL: Article
    DOI: 10.1177/1178630220959672
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2452946-1
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  • 4
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    KẾT QUẢ CHĂM SÓC NGƯỜI BỆNH MỔ VIÊM RUỘT THỪA VÀ MỘT SỐ YẾU TỐ LIÊN QUAN
    Vietnam Medical Journal, Vietnam Medical Association ; 2022
    In:  Tạp chí Y học Việt Nam Vol. 514, No. 1 ( 2022-06-20)
    Details
    In: Tạp chí Y học Việt Nam, Vietnam Medical Journal, Vietnam Medical Association, Vol. 514, No. 1 ( 2022-06-20)
    Abstract: Mục tiêu: mô tả kết quả chăm sóc người bệnh sau mổ viêm ruột thừa và một số yếu tố liên quan tại bệnh viện Bạch Mai năm 2021. Phương pháp: nghiên cứu mô tả tiến cứu. Kết quả: Trong 150 người bệnh được phẫu thuật cắt ruột thừa tại Bệnh viện Bạch Mai trong khoảng thời gian từ 1/2021 đến 4/2021. Tỷ lệ nữ và nam lần lượt là 53,3% và 46,7%. Tuổi trung bình của đối tượng nghiên cứu là 41,15 ± 18,5. Kết quả điều trị, chăm sóc của NB khi xuất viện có kết quả tốt và chưa tốt lần lượt là 76% và 24%. Yếu tố có bệnh kèm theo, số ngày nằm viện, các hoạt động tư vấn của điều dưỡng về dinh dưỡng, vận động sớm sau mổ, tuân thủ điều trị, theo dõi bất thường, vệ sinh cá nhân khi nằm viện có liên quan với kết quả chăm sóc của NB với OR lần lượt là 3,63; 2,7; 5,97; 3,74; 2,38; 5,50 với p 〈 0,05. Kết luận: Kết quả nghiên cứu cho thấy sự cần thiết của các đổi mới thực hành dựa trên bằng chứng để nâng cao hiệu quả của việc chăm sóc và điều trị sau phẫu thuật.
    Type of Medium: Online Resource
    ISSN: 1859-1868
    URL: Article
    DOI: 10.51298/vmj.v514i1.2557
    Language: Unknown
    Publisher: Vietnam Medical Journal, Vietnam Medical Association
    Publication Date: 2022
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  • 5
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    Online Resource
    Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study
    Springer Science and Business Media LLC ; 2020
    In:  Stem Cell Research & Therapy Vol. 11, No. 1 ( 2020-12)
    Details
    In: Stem Cell Research & Therapy, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2020-12)
    Abstract: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD results from chronic inflammation of the lungs. Current treatments, including physical and chemical therapies, provide limited results. Stem cells, particularly mesenchymal stem cells (MSCs), are used to treat COPD. Here, we evaluated the safety and efficacy of umbilical cord-derived (UC)-MSCs for treating COPD. Methods Twenty patients were enrolled, 9 at stage C and 11 at stage D per the Global Initiative for Obstructive Lung Disease (GOLD) classification. Patients were infused with 10 6 cells/kg of expanded allogeneic UC-MSCs. All patients were followed for 6 months after the first infusion. The treatment end-point included a comprehensive safety evaluation, pulmonary function testing (PFT), and quality-of-life indicators including questionnaires, the 6-min walk test (6MWT), and systemic inflammation assessments. All patients completed the full infusion and 6-month follow-up. Results No infusion-related toxicities, deaths, or severe adverse events occurred that were deemed related to UC-MSC administration. The UC-MSC-transplanted patients showed a significantly reduced Modified Medical Research Council score, COPD assessment test, and number of exacerbations. However, the forced expiratory volume in 1 s, C-reactive protein, and 6MWT values were nonsignificantly reduced after treatment (1, 3, and 6 months) compared with those before the treatment. Conclusion Systemic UC-MSC administration appears to be safe in patients with moderate-to-severe COPD, can significantly improve their quality of life, and provides a basis for subsequent cell therapy investigations. Trial registration ISRCTN, ISRCTN70443938 . Registered 06 July 2019
    Type of Medium: Online Resource
    ISSN: 1757-6512
    URL: Article
    DOI: 10.1186/s13287-020-1583-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2548671-8
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  • 6
    Online Resource
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    Real-world analysis of afatinib as a first-line treatment for patients with advanced stage non-small-cell lung cancer with uncommon EGFR mutations: a multicenter study in Vietnam
    SAGE Publications ; 2024
    In:  Therapeutic Advances in Medical Oncology Vol. 16 ( 2024-01)
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 16 ( 2024-01)
    Abstract: Afatinib is indicated for advanced-stage non-small-cell lung cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) and uncommon mutations. However, real-world studies on this topic are limited. This study aimed to evaluate afatinib as first-line therapy for locally advanced and metastatic NSCLC with uncommon EGFR mutations. Patients and methods: A retrospective study included 92 patients with advanced NSCLC with uncommon and compound EGFR mutations, treated with afatinib as first-line therapy. Patients were followed up and evaluated every 3 months or when symptoms of progressive disease arose. The endpoints were objective response rate (ORR), time-to-treatment failure (TTF), and adverse events. Results: The G719X EGFR mutation had the highest occurrence rate (53.3% for both monotherapy and the compound). By contrast, the compound mutation G719X–S768I was observed at a rate of 22.8%. The ORR was 75%, with 15.2% of patients achieving complete response. The overall median TTF was 13.8 months. Patients with the G719X EGFR mutation (single and compound) had a median TTF of 19.3 months, longer than that of patients with other mutations, who had a median TTF of 11.2 months. Patients with compound EGFR mutations (G719X and S768I) demonstrated a median TTF of 23.2 months compared to that of 12.3 months for other mutations. Tolerated doses of 20 or 30 mg achieved a longer median TTF of 17.1 months compared to 11.2 months with 40 mg. Median TTF differed between patients with and without brain metastasis, at 11.2 and 16.9 months, respectively. Rash (55.4%) and diarrhea (53.3%) were the most common adverse events, primarily grades 1 and 2. Other side effects occurred at a low rate. Conclusion: Afatinib is effective for locally advanced metastatic NSCLC with uncommon EGFR mutations. Patients with G719X, compound G719X–S768I mutations, and tolerated doses of 20 or 30 mg had a longer median TTF than those with other mutations.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359241242972
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2503443-1
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  • 7
    Online Resource
    Online Resource
    KẾT QUẢ ĐIỀU TRỊ AFATINIB LIỀU LINH HOẠT Ở BỆNH NHÂN CAO TUỔI UTPKTBN CÓ ĐỘT BIẾN EGFR
    Vietnam Medical Journal, Vietnam Medical Association ; 2024
    In:  Tạp chí Y học Việt Nam Vol. 537, No. 1B ( 2024-04-10)
    Details
    In: Tạp chí Y học Việt Nam, Vietnam Medical Journal, Vietnam Medical Association, Vol. 537, No. 1B ( 2024-04-10)
    Abstract: Mục tiêu: 1. Đánh giá kết quả điều trị Afatinib ở bệnh nhân cao tuổi UTPKTBN giai đoạn tiến xa có đột biến EGFR. 2. Nhận xét một số tác dung không mong muốn của điều trị trên nhóm bệnh nhân này. Bệnh nhân và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu, theo dõi dọc với mẫu thuận tiện gồm 230 bệnh nhân UTPKTBN giai đoạn IV ≥ 60 tuổi, có đột biến EGFR, điều trị tại 9 Khoa và Trung tâm Ung thư trên cả nước, từ 4/2018 – 06/2022 bằng Afatinib. Kết quả: Nghiên cứu được thực hiện trên 230 bệnh nhân. Tuổi trung bình là 68,4 tuổi, tỉ lệ nam 57,4%, tỉ lệ nữ 42,6%, phần lớn bệnh nhân có chỉ số toàn trạng ECOG PS 0 và 1, chiếm 94,3%; ECOG PS 2 và 3 chiếm 5,7%; 62,2% bệnh nhân không hút thuốc; di căn não và gan trước điều trị chiếm 26,5% và 7,8%. Các đột biến EGFR thường gặp (Del19, L858R) chiếm 71,7%, đột biến không thường gặp chiếm 28,3%. Bệnh nhân được khởi trị phần lớn với liều 30 mg (chiếm 59,6%) và 40mg (chiếm 38,7%), với tỉ lệ giữ nguyên liều sau 1 tháng điều trị chiếm 83,9%, tỉ lệ giảm liều chiếm 9,1%. Kết quả điều trị: tỉ lệ đáp ứng 76,5%, tỉ lệ kiểm soát bệnh: 91,7%, không khác biệt giữa điều trị liều trên hay dưới 40 mg; thời gian sống thêm đến khi thất bại điều trị (mTTF) là 16,6 tháng. Đối với bệnh nhân di căn não, tỉ lệ đáp ứng là 73,8%, mTTF 12,5 tháng. Tác dụng phụ trên da và niêm mạc chủ yếu gặp viêm quanh móng (chiếm 37%) và tiêu chảy (chiếm 58,3%), phần lớn độ 1,2, giảm liều theo dung nạp giúp kéo dài mTTF trong khi kiểm soát độc tính tốt hơn.
    Type of Medium: Online Resource
    ISSN: 1859-1868
    URL: Article
    DOI: 10.51298/vmj.v537i1B.9120
    Language: Unknown
    Publisher: Vietnam Medical Journal, Vietnam Medical Association
    Publication Date: 2024
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  • 8
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    A real-world cohort study of first-line afatinib in patients with EGFR-mutant advanced non-small cell lung cancer in Vietnam
    Springer Science and Business Media LLC ; 2024
    In:  BMC Cancer Vol. 24, No. 1 ( 2024-02-05)
    Details
    In: BMC Cancer, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2024-02-05)
    Abstract: This study aimed to evaluate the efficacy and side effects of first-line afatinib treatment in a real-world setting in Vietnam. Methods This retrospective study was conducted across nine hospitals in Vietnam. Advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients who received afatinib as first-line therapy between April 2018 and June 2022 were included, and patient medical records were reviewed. Key outcomes were overall response rate (ORR), time-to-treatment failure (TTF), and tolerability. Results A total of 343 patients on first-line afatinib were eligible for the study. EGFR exon 19 deletion (Del19) alone was detected in 46.9% of patients, L858R mutation alone in 26.3%, and other uncommon EGFR mutations, including compound mutations, in 26.8%. Patients with brain metastases at baseline were 25.4%. Patients who received 40 mg, 30 mg, and 20 mg as starting doses of afatinib were 58.6%, 39.9%, and 1.5%, respectively. The ORR was 78.1% in the overall population, 82.6% in the Del19 mutation subgroup, 73.3% in the L858R mutation subgroup, and 75.0% in the uncommon mutation subgroup ( p   〉  0.05). The univariate and multivariate analyses indicate that the ORR increased when the starting dose was 40 mg compared to starting doses below 40 mg (83.9% vs. 74.3%, p  = 0.034). The median TTF (mTTF) was 16.7 months (CI 95%: 14.8–18.5) in all patients, with a median follow-up time of 26.2 months. The mTTF was longer in patients in the common EGFR mutation subgroup (Del19/L858R) than in those in the uncommon mutation subgroup (17.5 vs. 13.8 months, p  = 0.045) and in those without versus with brain metastases at baseline (17.5 vs. 15.1 months, p  = 0.049). There were no significant differences in the mTTF between subgroups based on the starting dose of 40 mg and 〈  40 mg (16.7 vs. 16.9 months, p   〉  0.05). The most common treatment-related adverse events (any grade/grade ≥ 3) were diarrhea (55.4%/3.5%), rash (51.9%/3.2%), paronychia (35.3%/5.0%), and stomatitis (22.2%/1.2%). Conclusions Afatinib demonstrated clinical effectiveness and good tolerability in Vietnamese EGFR-mutant NSCLC patients. In our real-world setting, administering a starting dose below 40 mg might result in a reduction in ORR; however, it might not have a significant impact on TTF.
    Type of Medium: Online Resource
    ISSN: 1471-2407
    URL: Article
    DOI: 10.1186/s12885-024-11891-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2041352-X
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  • 9
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    A simple method for in vitro growth stimulation of tomato plantlets (Solanum lycopersicum) through supplementation of Rhizophagus irregularis MUCL43194 spores in the MS culture medium
    Springer Science and Business Media LLC ; 2023
    In:  Plant Cell, Tissue and Organ Culture (PCTOC) Vol. 153, No. 3 ( 2023-06), p. 577-586
    Details
    In: Plant Cell, Tissue and Organ Culture (PCTOC), Springer Science and Business Media LLC, Vol. 153, No. 3 ( 2023-06), p. 577-586
    Type of Medium: Online Resource
    ISSN: 0167-6857 , 1573-5044
    URL: Article
    DOI: 10.1007/s11240-023-02493-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 406394-6
    detail.hit.zdb_id: 1478391-5
    SSG: 12
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  • 10
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    SỰ SẴN SÀNG THAM GIA HOẠT ĐỘNG TÌNH NGUYỆN PHÒNG, CHỐNG DỊCH COVID-19 CỦA SINH VIÊN NĂM THỨ 5 NGÀNH BÁC SỸ Y KHOA, TRƯỜNG ĐẠI HỌC Y HÀ NỘI, NĂM 2022
    Vietnam Medical Journal, Vietnam Medical Association ; 2023
    In:  Tạp chí Y học Việt Nam Vol. 523, No. 1 ( 2023-02-24)
    Details
    In: Tạp chí Y học Việt Nam, Vietnam Medical Journal, Vietnam Medical Association, Vol. 523, No. 1 ( 2023-02-24)
    Abstract: Đặt vấn đề: Sinh viên khối ngành Y Dược là 1 trong những lực lượng đông đảo và hết sức quan trọng tham gia phong trào tình nguyện phòng, chống dịch COVID-19. Mục tiêu: Mô tả sự sẵn sàng tham gia hoạt động tình nguyện phòng, chống dịch COVID-19 của sinh viên năm thứ 5 ngành Bác sỹ Y khoa trường Đại học Y Hà Nội. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang được thực hiện trên 435 sinh viên năm thứ 5 ngành Bác sỹ Y khoa, bằng bộ câu hỏi qua online. Kết quả: phần lớn sinh viên được hỏi sẵn sàng tham gia hoạt động tình nguyện phòng, chống dịch COVID-19 nếu được huy động (73,6%). Vinh dự được đóng góp cho cộng đồng (97,8%); Lòng yêu nước, trách nhiệm đối với cộng đồng, xã hội (96,9%); Chế độ khen thưởng và hỗ trợ kinh phí (96,9%) là những động lực thúc đẩy sinh viên tham gia tình nguyện. Bên cạnh đó: Tập trung cho việc học tập, ôn thi nội trú (87,8%); Nguy cơ có thể bị nhiễm bệnh và lây cho gia đình (84,3%); Lo lắng không đủ kiến thức, kỹ năng (75,7%) cũng là những trở ngại khiến nhiều em chưa sẵn sàng tham gia. Kết luận: Hầu hết sinh viên Y khoa năm thứ 5 đều sẵn sàng tham gia hoạt động tình nguyện phóng, chống dịch COVID-19 nếu được huy động. Tinh thần nhiệt huyết ấy rất đáng được biểu dương, khuyến khích bằng các chế độ, chính sách khen thưởng xứng đáng, kịp thời.
    Type of Medium: Online Resource
    ISSN: 1859-1868
    URL: Article
    DOI: 10.51298/vmj.v523i1.4439
    Language: Unknown
    Publisher: Vietnam Medical Journal, Vietnam Medical Association
    Publication Date: 2023
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