In:
Experimental Biology and Medicine, SAGE Publications, Vol. 233, No. 5 ( 2008-05), p. 549-557
Abstract:
In rats fed a high fat diet (HFD), long-term administration of 3,5-diiodo-L-thyronine (T 2 ), a naturally occurring iodothyronine, was shown to reduce body-weight gain, fat mass, and hepatic lipid accumulation. This work was aimed at investigating the mechanisms of T 2 action in the liver of HFD rats. The results show that HFD induces liver lipid peroxidation and stimulates the activity of enzymes involved in hydrogen peroxide (H 2 O 2 ) metabolism, catalase in particular. Moreover, quantitative RT-PCR revealed HFD-induced upregulation of the transcription factor PPARα, as well as of metallothionein isoforms (MT-1 and MT-2). T 2 administration prevented the HDF-induced lipid peroxidation, as well as the increase in H 2 O 2 metabolism, and reduced the upregulation of both PPARα and MT-2. These data demonstrate that in the liver of HFD rats, T 2 prevents both lipid accumulation and oxidative stress associated with increased fat metabolism.
Type of Medium:
Online Resource
ISSN:
1535-3702
,
1535-3699
Language:
English
Publisher:
SAGE Publications
Publication Date:
2008
detail.hit.zdb_id:
2020856-X
SSG:
12
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