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  • 1
    In: International Journal of Public Health, Frontiers Media SA, Vol. 66 ( 2021-6-23)
    Abstract: Objectives: We explored the association of underlying health conditions (UHC) with depression and anxiety, and examined the modification effects of suspected COVID-19 symptoms (S-COVID-19-S), health-related behaviors (HB), and preventive behaviors (PB). Methods: A cross-sectional study was conducted on 8,291 outpatients aged 18–85 years, in 18 hospitals and health centers across Vietnam from 14th February to May 31, 2020. We collected the data regarding participant's characteristics, UHC, HB, PB, depression, and anxiety. Results: People with UHC had higher odds of depression (OR = 2.11; p & lt; 0.001) and anxiety (OR = 2.86; p & lt; 0.001) than those without UHC. The odds of depression and anxiety were significantly higher for those with UHC and S-COVID-19-S ( p & lt; 0.001); and were significantly lower for those had UHC and interacted with “unchanged/more” physical activity ( p & lt; 0.001), or “unchanged/more” drinking ( p & lt; 0.001 for only anxiety), or “unchanged/healthier” eating ( p & lt; 0.001), and high PB score ( p & lt; 0.001), as compared to those without UHC and without S-COVID-19-S, “never/stopped/less” physical activity, drinking, “less healthy” eating, and low PB score, respectively. Conclusion: S-COVID-19-S worsen psychological health in patients with UHC. Physical activity, drinking, healthier eating, and high PB score were protective factors.
    Type of Medium: Online Resource
    ISSN: 1661-8564
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2276416-1
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  • 2
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 7 ( 2020-11-16)
    Type of Medium: Online Resource
    ISSN: 2296-861X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2776676-7
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  • 3
    In: Journal of Medical Internet Research, JMIR Publications Inc., Vol. 22, No. 11 ( 2020-11-12), p. e22894-
    Abstract: The COVID-19 pandemic has imposed a heavy burden on health care systems and governments. Health literacy (HL) and eHealth literacy (as measured by the eHealth Literacy Scale [eHEALS]) are recognized as strategic public health elements but they have been underestimated during the pandemic. HL, eHEALS score, practices, lifestyles, and the health status of health care workers (HCWs) play crucial roles in containing the COVID-19 pandemic. Objective The aim of this study is to evaluate the psychometric properties of the eHEALS and examine associations of HL and eHEALS scores with adherence to infection prevention and control (IPC) procedures, lifestyle changes, and suspected COVID-19 symptoms among HCWs during lockdown. Methods We conducted an online survey of 5209 HCWs from 15 hospitals and health centers across Vietnam from April 6 to April 19, 2020. Participants answered questions related to sociodemographics, HL, eHEALS, adherence to IPC procedures, behavior changes in eating, smoking, drinking, and physical activity, and suspected COVID-19 symptoms. Principal component analysis, correlation analysis, and bivariate and multivariate linear and logistic regression models were used to validate the eHEALS and examine associations. Results The eHEALS had a satisfactory construct validity with 8 items highly loaded on one component, with factor loadings ranked from 0.78 to 0.92 explaining 76.34% of variance; satisfactory criterion validity as correlated with HL (ρ=0.42); satisfactory convergent validity with high item-scale correlations (ρ=0.80-0.84); and high internal consistency (Cronbach α=.95). HL and eHEALS scores were significantly higher in men (unstandardized coefficient [B]=1.01, 95% CI 0.57-1.45, P 〈 .001; B=0.72, 95% CI 0.43-1.00, P 〈 .001), those with a better ability to pay for medication (B=1.65, 95% CI 1.25-2.05, P 〈 .001; B=0.60, 95% CI 0.34-0.86, P 〈 .001), doctors (B=1.29, 95% CI 0.73-1.84, P 〈 .001; B 0.56, 95% CI 0.20-0.93, P=.003), and those with epidemic containment experience (B=1.96, 95% CI 1.56-2.37, P 〈 .001; B=0.64, 95% CI 0.38-0.91, P 〈 .001), as compared to their counterparts, respectively. HCWs with higher HL or eHEALS scores had better adherence to IPC procedures (B=0.13, 95% CI 0.10-0.15, P 〈 .001; B=0.22, 95% CI 0.19-0.26, P 〈 .001), had a higher likelihood of healthy eating (odds ratio [OR] 1.04, 95% CI 1.01-1.06, P=.001; OR 1.04, 95% CI 1.02-1.07, P=.002), were more physically active (OR 1.03, 95% CI 1.02-1.03, P 〈 .001; OR 1.04, 95% CI 1.03-1.05, P 〈 .001), and had a lower likelihood of suspected COVID-19 symptoms (OR 0.97, 95% CI 0.96-0.98, P 〈 .001; OR 0.96, 95% CI 0.95-0.98, P 〈 .001), respectively. Conclusions The eHEALS is a valid and reliable survey tool. Gender, ability to pay for medication, profession, and epidemic containment experience were independent predictors of HL and eHEALS scores. HCWs with higher HL or eHEALS scores had better adherence to IPC procedures, healthier lifestyles, and a lower likelihood of suspected COVID-19 symptoms. Efforts to improve HCWs’ HL and eHEALS scores can help to contain the COVID-19 pandemic and minimize its consequences.
    Type of Medium: Online Resource
    ISSN: 1438-8871
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2020
    detail.hit.zdb_id: 2028830-X
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  • 4
    In: BMJ Open, BMJ, Vol. 10, No. 12 ( 2020-12), p. e041394-
    Abstract: We examined impacts and interactions of COVID-19 response involvement, health-related behaviours and health literacy (HL) on anxiety, depression, and health-related quality of life (HRQoL) among healthcare workers (HCWs). Design A cross-sectional study was conducted. Data were collected 6 April to 19 April 2020 using online-based, self-administered questionnaires. Setting 19 hospitals and health centres in Vietnam. Participants 7 124 HCWs aged 21–60 years. Results The COVID-19 response-involved HCWs had higher anxiety likelihood (OR (95% CI)=4.41 (3.53 to 5.51)), higher depression likelihood (OR(95% CI)=3.31 (2.71 to 4.05)) and lower HRQoL score (coefficient, b(95% CI)=−2.14 (−2.89 to −1.38)), compared with uninvolved HCWs. Overall, HCWs who smoked or drank at unchanged/increased levels had higher likelihood of anxiety, depression and lower HRQoL scores; those with unchanged/healthier eating, unchanged/more physical activity and higher HL scores had lower likelihood of anxiety, depression and higher HRQoL scores. In comparison to uninvolved HCWs who smoked or drank at never/stopped/reduced levels, involved HCWs with unchanged/increased smoking or drinking had lower anxiety likelihood (OR(95% CI)=0.34 (0.14 to 0.83)) or (OR(95% CI)=0.26 (0.11 to 0.60)), and lower depression likelihood (OR(95% CI)=0.33 (0.15 to 0.74)) or (OR(95% CI)=0.24 (0.11 to 0.53)), respectively. In comparison with uninvolved HCWs who exercised at never/stopped/reduced levels, or with those in the lowest HL quartile, involved HCWs with unchanged/increased exercise or with one-quartile HL increment reported lower anxiety likelihood (OR(95% CI)=0.50 (0.31 to 0.81)) or (OR(95% CI)=0.57 (0.45 to 0.71)), lower depression likelihood (OR(95% CI)=0.40 (0.27 to 0.61)) or (OR(95% CI)=0.63 (0.52 to 0.76)), and higher HRQoL scores (b(95% CI)=2.08 (0.58 to 3.58)), or (b(95% CI)=1.10 (0.42 to 1.78)), respectively. Conclusions Physical activity and higher HL were found to protect against anxiety and depression and were associated with higher HRQoL. Unexpectedly, smoking and drinking were also found to be coping behaviours. It is important to have strategic approaches that protect HCWs’ mental health and HRQoL.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    Language: English
    Publisher: BMJ
    Publication Date: 2020
    detail.hit.zdb_id: 2599832-8
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  • 5
    In: Tropical Medicine & International Health, Wiley, Vol. 20, No. 5 ( 2015-05), p. 627-637
    Abstract: Determinar el nivel de adherencia de los médicos a las guías de prescripción para el síndrome coronario agudo ( SCA ) en hospitales de Vietnam. Métodos Estudio croseccional retrospectivo de historias médicas de pacientes con SCA admitidos en dos hospitales públicos en la Ciudad de Ho Chi Minh, Vietnam, entre Enero y Diciembre del 2013. Se determinaron los porcentajes de pacientes elegibles que recibían la medicación recomendada en las guías. Se identificaron los factores asociados con la no‐adherencia mediante una regresión logística multivariante. Resultados En total se revisaron 711 historias clínicas y se encontraron 284 pacientes que cumplían con los criterios de inclusión (edad media 64 años; 69.4% hombres). De entre los pacientes elegibles para recibir tratamiento, se prescribió aspirina al 97.9% al ser admitidos y a 96.3% al ser dados de alta; se prescribió terapia antiplaquetaria dual al 92.3% al ser admitidos y a un 91.7% al ser dados de alta; se prescribieron dosis de carga para un 79.5% en el caso de la aspirina y a un 55.8% con clopidogrel; se prescribieron beta‐bloqueantes a un 58.7% al ingresar y a un 76.7% al ser dados de alta; los inhibidores de la enzima convertidora de angiotensina o bloqueadores del receptor de la angiotensina ( IECA / BRA ) fueron prescritos en un 89.1% de los casos al ingreso y al ser dados de alta; y se prescribieron estatinas al 94.1% al ingreso y al 90.7% al ser dados de alta. Los pacientes con un procedimiento invasivo tenían mayor probabilidad de recibir un tratamiento acorde con el recomendado en las guías en el momento de ser dados de alta: terapia antiplaquetaria dual ( OR 3.77; IC 95% 1.23‐11.52), beta bloqueantes ( OR 3.95; IC 95% CI 1.86‐8.40), y IECA / BRA ( OR 4.01; IC 95% 1.30‐12.41). Noventa de los pacientes excluidos fueron dados de alta sin completar el tratamiento. Conclusiones En general, los médicos se adherían a las guías de prescripción para SCA dentro de la práctica hospitalaria en Vietnam. La prescripción de las dosis de carga de betabloqueantes y clopidogrel era probablemente inadecuada. El porqué los pacientes no completaban el tratamiento requiere ser investigado.
    Type of Medium: Online Resource
    ISSN: 1360-2276 , 1365-3156
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2018112-7
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  • 6
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2022
    In:  International Journal of Pharmacy Practice Vol. 30, No. 5 ( 2022-11-04), p. 449-456
    In: International Journal of Pharmacy Practice, Oxford University Press (OUP), Vol. 30, No. 5 ( 2022-11-04), p. 449-456
    Abstract: We aimed to assess whether a pharmacist-led intervention enhances knowledge, medication adherence and glycemic control in patients with type 2 diabetes mellitus (T2DM). Methods We conducted a single-blinded randomized controlled trial in Vietnam. Individuals with T2DM were recruited from a general hospital and randomly allocated to intervention and routine care. The intervention group received routine care plus counselling intervention by a pharmacist, including providing drug information and answering individual patients’ queries relating to T2DM and medications, which had not been done in routine care. We assessed the outcomes: knowledge score as measured by the Diabetes Knowledge Questionnaire, self-reported adherence and fasting blood glucose (FBG) at the 1-month follow-up. Key findings A total of 165 patients (83 intervention, 82 control) completed the study; their mean age was 63.33 years, and 49.1% were males. The baseline characteristics of the patients were similar between the groups. At 1-month follow-up, the pharmacist’s intervention resulted in an improvement in all three outcomes: knowledge score [B = 5.527; 95% confidence intervals (CI): 3.982 to 7.072; P & lt; 0.001], adherence [odds ratio (OR) = 9.813; 95% CI: 2.456 to 39.205; P = 0.001] and attainment of target FBG (OR = 1.979; 95% CI: 1.029 to 3.806; P = 0.041). Conclusions The pharmacist-led intervention enhanced disease knowledge, medication adherence and glycemic control in patients with T2DM. This study provides evidence of the benefits of pharmacist counselling in addition to routine care for T2DM outpatients in a Vietnam population.
    Type of Medium: Online Resource
    ISSN: 0961-7671 , 2042-7174
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2122383-X
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    World Scientific Pub Co Pte Ltd ; 2020
    In:  International Journal of Computational Methods Vol. 17, No. 08 ( 2020-10), p. 1950057-
    In: International Journal of Computational Methods, World Scientific Pub Co Pte Ltd, Vol. 17, No. 08 ( 2020-10), p. 1950057-
    Abstract: So far, the carbon nanotube (CNT) distributions have been still limited in the linear forms, which may lead to the limitations in maximizing the strength and potential of carbon nanotube reinforced composite (CNTRC) structures. This study, hence proposes a type of novel CNTs distribution for improving the stiffness of CNTRC beams. The distributions are in the nonlinear forms and ensure the same total CNT volume fraction along the thickness of structures. For demonstrating, the effectiveness of the proposed CNT distributions, the static, free vibration and buckling analyses of functionally graded carbon nanotube (FG-CNT) reinforced composite beams using the new CNT distributions are conducted and one-dimensional NURSB basis functions based on the third-order shear deformation theory (TSDT) are utilized to describe the exact geometry and to approximate the unknown solution in finite element model of the beam. The numerical investigations of the geometric and material parameters reveal that the new nonlinear CNT distributions can help increase the normalized frequency, buckling load and the nondimensional central deflection to the maxima of 8%, 16% and 16% respectively, in some conditions of geometric parameters.
    Type of Medium: Online Resource
    ISSN: 0219-8762 , 1793-6969
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2020
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  • 8
    In: Biomolecules, MDPI AG, Vol. 10, No. 1 ( 2019-12-24), p. 31-
    Abstract: Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-l-oxoproline and Cys-Gly specifically in the cytosol. Here, we report the crystal structures of ChaC2 in two different conformations and compare the structural features with other known γ-glutamylcyclotransferase enzymes. The unique flexible loop of ChaC2 seems to function as a gate to achieve specificity for GSH binding and regulate the constant GSH degradation rate. Structural and biochemical analyses of ChaC2 revealed that Glu74 and Glu83 play crucial roles in directing the conformation of the enzyme and in modulating the enzyme activity. Based on a docking study of GSH to ChaC2 and binding assays, we propose a substrate-binding mode and catalytic mechanism. We also found that overexpression of ChaC2, but not mutants that inhibit activity of ChaC2, significantly promoted breast cancer cell proliferation, suggesting that the GSH degradation by ChaC2 affects the growth of breast cancer cells. Our structural and functional analyses of ChaC2 will contribute to the development of inhibitors for the ChaC family, which could effectively regulate the progression of GSH degradation-related cancers.
    Type of Medium: Online Resource
    ISSN: 2218-273X
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2701262-1
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  • 9
    Online Resource
    Online Resource
    Institution of Engineering and Technology (IET) ; 2019
    In:  The Journal of Engineering Vol. 2019, No. 18 ( 2019-07), p. 5007-5011
    In: The Journal of Engineering, Institution of Engineering and Technology (IET), Vol. 2019, No. 18 ( 2019-07), p. 5007-5011
    Type of Medium: Online Resource
    ISSN: 2051-3305 , 2051-3305
    URL: Issue
    Language: English
    Publisher: Institution of Engineering and Technology (IET)
    Publication Date: 2019
    detail.hit.zdb_id: 2727074-9
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2006
    In:  New Forests Vol. 32, No. 1 ( 2006-07), p. 9-19
    In: New Forests, Springer Science and Business Media LLC, Vol. 32, No. 1 ( 2006-07), p. 9-19
    Type of Medium: Online Resource
    ISSN: 0169-4286 , 1573-5095
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2006
    detail.hit.zdb_id: 2016205-4
    SSG: 23
    SSG: 12
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