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  • 1
    Online Resource
    Online Resource
    Co-infection and ICU-acquired infection in COVID-19 ICU patients: a secondary analysis of the UNITE-COVID data set
    Springer Science and Business Media LLC ; 2022
    In:  Critical Care Vol. 26, No. 1 ( 2022-08-03)
    Details
    In: Critical Care, Springer Science and Business Media LLC, Vol. 26, No. 1 ( 2022-08-03)
    Abstract: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients. Methods This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson’s Chi-squared and continuous variables by Mann–Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the “full” matching method. Results Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, 71% of patients receiving corticosteroids developed ICU-AI vs 52% of those not receiving corticosteroids. Duration of corticosteroid therapy was also associated with development of ICU-AI and infection with an MDRO. Conclusions In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated with use of corticosteroids. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021). Graphical abstract
    Type of Medium: Online Resource
    ISSN: 1364-8535
    URL: Article
    DOI: 10.1186/s13054-022-04108-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2051256-9
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  • 2
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    Coexistence of Tumor-Induced Osteomalacia and Primary Hyperparathyroidism
    Elsevier BV ; 2011
    In:  Endocrine Practice Vol. 17, No. 6 ( 2011-11), p. 144-148
    Details
    In: Endocrine Practice, Elsevier BV, Vol. 17, No. 6 ( 2011-11), p. 144-148
    Type of Medium: Online Resource
    ISSN: 1530-891X
    URL: Article
    DOI: 10.4158/EP11177.CR
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
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  • 3
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    Assessment of Synergistic Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Sarcoma
    Springer Science and Business Media LLC ; 2020
    In:  Molecular Diagnosis & Therapy Vol. 24, No. 5 ( 2020-10), p. 557-569
    Details
    In: Molecular Diagnosis & Therapy, Springer Science and Business Media LLC, Vol. 24, No. 5 ( 2020-10), p. 557-569
    Type of Medium: Online Resource
    ISSN: 1177-1062 , 1179-2000
    URL: Article
    DOI: 10.1007/s40291-020-00487-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2232973-0
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  • 4
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    Conditioning attenuates kidney and heart injury in rats following transient suprarenal occlusion of the abdominal aorta
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-03-19)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-03-19)
    Abstract: Suprarenal aortic clamping during abdominal aortic aneurysm (AAA) repair results in ischemia-reperfusion injury (IRI) in local (i.e. kidney) and distant (i.e. heart) tissue. To investigate perioperative approaches that mitigate IRI-induced tissue damage, Wistar rats underwent suprarenal aortic clamping either alone or in combination with short cycles of ischemic conditioning before and/or after clamping. Serum analysis revealed significant reduction in key biochemical parameters reflecting decreased tissue damage at systemic level and improved renal function in conditioned groups compared to controls (p  〈  0.05), which was corroborated by histolopathological evaluation. Importantly, the levels of DNA damage, as reflected by the biomarkers 8-oxo-G, γH2AX and pATM were reduced in conditioned versus non-conditioned cases. In this setting, NADPH oxidase, a source of free radicals, decreased in the myocardium of conditioned cases. Of note, administration of 5-HD and 8-SPT blocking key protective signaling routes abrogated the salutary effect of conditioning. To further understand the non-targeted effect of IRI on the heart, it was noted that serum TGF-β1 levels decreased in conditioned groups, whereas this difference was eliminated after 5-HD and 8-SPT administration. Collectively, conditioning strategies reduced both renal and myocardial injury. Additionally, the present study highlights TGF-β1 as an attractive target for manipulation in this context.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-61268-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 5
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    Cloud-Based Platform for Optimal Machining Parameter Selection Based on Function Blocks and Real-Time Monitoring
    ASME International ; 2015
    In:  Journal of Manufacturing Science and Engineering Vol. 137, No. 4 ( 2015-08-01)
    Details
    In: Journal of Manufacturing Science and Engineering, ASME International, Vol. 137, No. 4 ( 2015-08-01)
    Abstract: The way machining operations have been running has changed over the years. Nowadays, machine utilization and availability monitoring are becoming increasingly important for the smooth operation of modern workshops. Moreover, the nature of jobs undertaken by manufacturing small and medium enterprises (SMEs) has shifted from a mass production to small batch. To address the challenges caused by modern fast changing environments, a new cloud-based approach for monitoring the use of manufacturing equipment, dispatching jobs to the selected computer numerical control (CNC) machines, and creating the optimum machining code is presented. In this approach the manufacturing equipment is monitored using a sensor network and though an information fusion technique it derives and broadcasts the data of available tools and machines through the internet to a cloud-based platform. On the manufacturing equipment event driven function blocks with embedded optimization algorithms are responsible for selecting the optimal cutting parameters and generating the moves required for machining the parts while considering the latest information regarding the available machines and cutting tools. A case study based on scenario from a shop floor that undertakes machining jobs is used to demonstrate the developed methods and tools.
    Type of Medium: Online Resource
    ISSN: 1087-1357 , 1528-8935
    URL: Article
    DOI: 10.1115/1.4029806
    Language: English
    Publisher: ASME International
    Publication Date: 2015
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  • 6
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    Online Resource
    Cloud-Based Augmented Reality Remote Maintenance Through Shop-Floor Monitoring: A Product-Service System Approach
    ASME International ; 2017
    In:  Journal of Manufacturing Science and Engineering Vol. 139, No. 6 ( 2017-06-01)
    Details
    In: Journal of Manufacturing Science and Engineering, ASME International, Vol. 139, No. 6 ( 2017-06-01)
    Abstract: Maintenance and its cost continue, over the years, drawing the attention of production management, since the unplanned failures decrease the reliability of the system and the return of investments. Maintenance services of manufactured products are among the most common services in the industry; they account for more than half of the total costs and influence the environmental impact of the product. In order for manufacturers to increase their productivity, by performing accurate and quick maintenance, advanced monitoring systems should be considered in order to easily detect machine tool failures before they occur. Toward that end, a cloud-based platform for condition-based preventive maintenance, supported by a shop-floor monitoring service and an augmented reality (AR) application, is proposed as a product-service system (CARM2-PSS). The proposed AR maintenance service consists of algorithms of automated generation of assembly sequences, part movement scripts, and improved interface that aim to maximize existing knowledge usage while creating vivid AR service instructions. Moreover, the proposed monitoring system is supported by a wireless sensor network (WSN), and is deployed on a Cloud environment together with the AR tool. The monitoring system monitors the status of the machine tools, calculates their remaining operating time between failures (ROTBF), and identifies the available windows of the machine tools in order to perform the AR remote maintenance. In order to validate the proposed methodology and calculate its impact, it is applied in a real-life case study of a white-goods industry.
    Type of Medium: Online Resource
    ISSN: 1087-1357 , 1528-8935
    URL: Article
    DOI: 10.1115/1.4035721
    Language: English
    Publisher: ASME International
    Publication Date: 2017
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  • 7
    Online Resource
    Online Resource
    Investigation of the Effects of the Explant Type and Different Plant Growth Regulators on Micropropagation of Five Mediterranean Salvia spp. Native to Greece
    MDPI AG ; 2023
    In:  Horticulturae Vol. 9, No. 1 ( 2023-01-11), p. 96-
    Details
    In: Horticulturae, MDPI AG, Vol. 9, No. 1 ( 2023-01-11), p. 96-
    Abstract: Sages are medicinal and aromatic plants that constitute a large pool from which active compounds of great pharmaceutical potential can be derived, while at the same time, they also have ornamental value. The purpose of this study was to develop the micropropagation protocols of Salvia fruticosa, S. officinalis, S. ringens, S. tomentosa, and S. pomifera ssp. pomifera to facilitate their exploitation in the pharmaceutical and floriculture industries. In vitro cultures of S. ringens and S. pomifera ssp. pomifera was studied for the first time. Shoot tips and single node explants from in vitro seedlings were initially cultured on hormone free (Hf)-MS medium, followed by subcultures on MS medium supplemented with 6-benzyladenine (BA) for all species, as well as with zeatin (ZEA), kinetin (KIN), 6-(γ,γ-dimethylallyamino) purine (2iP), or meta-topolin (mT) for S. fruticosa and S. officinalis, at concentrations 0.0 to 3.2 mg L−1, in combination with 0.01 mg L−1 1-naphthaleneacetic acid (NAA). S. officinalis was the most efficient in shoot multiplication of all the studied species. The highest multiplication indices were found using 0.8 mg L−1 BA for S. fruticosa, 0.4 mg L−1 BA, or mT for S. officinalis, and lower than 0.8 mg L−1 BA for the other three species. Hyperhydricity was a problem at the multiplication stage, and was most pronounced in single node explants, increasing in proportion to cytokinin concentration. Microshoots rooted at high percentages (75–85%) on half-strength MS medium with 0.0 or 0.5 mg L−1 Indole-3-butyric acid (IBA), except for those of S. ringens, which rooted best at 1.0–2.0 mg L−1 IBA. Ex vitro acclimatization was highly successful (80–95%) on peat–perlite substrate (1:1 v/v). Thus, the present study resulted in efficient micropropagation protocols for five Mediterranean sage species native to Greece, which will facilitate breeding programs and the promotion of these species in the floriculture and pharmaceutical industries.
    Type of Medium: Online Resource
    ISSN: 2311-7524
    URL: Article
    DOI: 10.3390/horticulturae9010096
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2813983-5
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  • 8
    Online Resource
    Online Resource
    Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic® F-127 Nanomicelles
    MDPI AG ; 2023
    In:  Materials Vol. 16, No. 13 ( 2023-06-29), p. 4715-
    Details
    In: Materials, MDPI AG, Vol. 16, No. 13 ( 2023-06-29), p. 4715-
    Abstract: The anionic polymer sodium alginate, a linear copolymer of guluronic and mannuronic acids, is primarily present in brown algae. Copolymers are used in the sodium alginate preparation process to confer on the material strength and flexibility. Micelles and other polymeric nanoparticles are frequently made using the triblock copolymer Pluronic® F-127. The purpose of the present study is to determine the effect of sodium alginate’s viscosity (low and medium) and the presence of Pluronic® F-127 micelles on the swelling behavior of the prepared pure beads and those loaded with Pluronic® F-127 micelles. The Pluronic® F-127 nanomicelles have a size of 120 nm. The swelling studies were carried out at pH = 1.2 (simulated gastric fluid-SGF) for two hours and at pH = 6.8 (simulated intestinal fluid-SIF) for four more hours. The swelling of both low- and medium-viscosity alginate beads was minor at pH = 1.2, irrespective of the use of Pluronic® F-127 nanomicelles. At pH = 6.8, without Pluronic® F-127, the beads showed an enhanced swelling ratio for the first four hours, which was even higher in the medium-viscosity alginate beads. With the addition of Pluronic® F-127, the beads were dissolved in the first and second hour, in the case of the low- and medium-alginate’s viscosity, respectively. In other words, the behavior of the mixed hydrogels was the same during the swelling experiments. Therefore, the presence of Pluronic® F-127 nanomicelles and medium-viscosity sodium alginate leads to a higher swelling ratio. A model drug, acetyl salicylic acid (ASA), was also encapsulated in the mixed beads and ASA’s release studies were performed. In conclusion, the prepared systems, which are well characterized, show potential as delivery platforms for the oral delivery of active pharmaceutical ingredients and biopharmaceuticals.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma16134715
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2487261-1
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  • 9
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    Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review)
    Spandidos Publications ; 2021
    In:  International Journal of Molecular Medicine Vol. 47, No. 4 ( 2021-02-09)
    Details
    In: International Journal of Molecular Medicine, Spandidos Publications, Vol. 47, No. 4 ( 2021-02-09)
    Type of Medium: Online Resource
    ISSN: 1107-3756 , 1791-244X
    URL: Journal
    URL: Article
    DOI: 10.3892/ijmm
    DOI: 10.3892/ijmm.2021.4880
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2083937-6
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  • 10
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    Online Resource
    FinTech’s rapid growth and its effect on the banking sector
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Banking and Financial Technology Vol. 6, No. 2 ( 2022-10), p. 159-176
    Details
    In: Journal of Banking and Financial Technology, Springer Science and Business Media LLC, Vol. 6, No. 2 ( 2022-10), p. 159-176
    Abstract: FinTech is a New Financial Technology, which provides financial services through innovative information and communication technologies. It is widely accepted that 4th industrial revolution, has affected tremendously the living and working conditions of the societies. The convergence between advanced technologies, entrepreneurship becomes more complex and remarkably computerized. Within such significant changes it is rather expected that banking, has been one of the most challenged sectors. New players like FinTech and Big Tech companies try to capitalize the circumstances, by promoting new consumer patterns to gain market shares. The purpose of this study is to investigate the rapid expansion of FinTech and to evaluate its impact on the Greek banking system. This topic becomes very important nowadays as the number of FinTech companies, which compete with traditional banks on financial products and services, are increasing constantly as digital technology develops. In our study we apply a questionnaire method mainly with closed questions to collect data from the main players. To do this, we use two questionnaires each one for a different sample. The first sample consists of the consumers for financial products and services in the Greek banking sector and the second sample consists of the employees in the Greek banking sector. According to the results, customers of all ages seem to trust the traditional banks more than FinTech companies whereas the level of mobile transactions separately for each consumer, depends on age and education. From the answers of the consumers, it is clear that security is on the top of their worries for using financial services by FinTech companies. On the other hand, the second questionnaire with bank employees shows clearly that educational level is a critical factor for their readiness and response to new technologies.
    Type of Medium: Online Resource
    ISSN: 2524-7956 , 2524-7964
    URL: Article
    DOI: 10.1007/s42786-022-00045-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2955858-X
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