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  • 1
    In: Oncotarget, Impact Journals, LLC, Vol. 12, No. 7 ( 2021-03-30), p. 698-707
    Type of Medium: Online Resource
    ISSN: 1949-2553
    URL: Issue
    Language: English
    Publisher: Impact Journals, LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2560162-3
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  • 2
    In: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, JCDR Research and Publications, ( 2018)
    Type of Medium: Online Resource
    ISSN: 2249-782X
    Language: Unknown
    Publisher: JCDR Research and Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2775283-5
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  • 3
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2021
    In:  Pediatric Traumatology, Orthopaedics and Reconstructive Surgery Vol. 9, No. 3 ( 2021-10-04), p. 367-376
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 9, No. 3 ( 2021-10-04), p. 367-376
    Abstract: BACKGROUND: Congenital deformities of the spine are a group of serious congenital defects of the vertebrae, which can manifest themselves in the clinical picture as an isolated pathology of the axial musculoskeletal system, and are associated with congenital defects of internal organs and other systems. Recently, the TBX6 gene has been identified as the genetic cause of congenital scoliosis in about 11% of cases. This subtype of scoliosis is classified as TBX6-associated congenital scoliosis. The TBX6-associated congenital scoliosis phenotype is characterized by butterfly-shaped vertebrae and hemivertebrae in the lower thoracic and lumbar regions without pronounced malformations of the spinal cord. AIM: Our aim is to study and evaluate data from foreign and domestic scientific publications devoted to the study of the candidate gene for congenital scoliosis TBX6. MATERIALS AND METHODS: The following databases of scientific publications such as PubMed, Cochrane Library, Web of Science, SCOPUS, MEDLINE, e-Library, Cyberleninka were used to write this review. The inclusion criteria were systematic reviews, meta-analyses, multicenter studies, controlled cohort studies, uncontrolled cohort studies of patients with congenital spinal deformities. The exclusion criteria were clinical cases, observations, conference proceedings, congenital scoliosis in genetic syndromes, congenital scoliosis associated with defects of the nervous system. RESULTS: In order to achieve this goal, 70 scientific publications were studied relating to the data analysis of the candidate gene for congenital scoliosis TBX6. Among 49 publications that were identified, 2 were domestics, and the rest were foreign publications. These studies provided information on the molecular analysis of genes that cause congenital spinal deformities in humans and animals. CONCLUSIONS: An analysis of the published research work on this topic indicates the presence of a significant effect of mutations in the TBX6 gene, leading to the appearance of congenital scoliosis. Advances in elucidating the genetic contribution to the development of congenital spinal deformities and the molecular etiology of clinical phenotypes may uncover the opportunities for further refinement of the classification of signs of congenital scoliosis in accordance with the underlying genetic etiology.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2021
    detail.hit.zdb_id: 3046142-X
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  • 4
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 11, No. 3 ( 2023-10-08), p. 327-336
    Abstract: BACKGROUND: A combination of movement disorders with contractures in the joints is a feature of upper limb lesions in patients with spastic forms of cerebral palsy. As part of the spastic hand syndrome, contractures are differentiated into primary and secondary. Primary contractures are caused by muscle spasticity, whereas secondary contractures are caused by the structural shortening of the muscle motor segment in relation to the bone, which can subsequently lead to deformities of articular surfaces. In theory, the use of diagnostic blockade as a mandatory procedure in patient examination before selective neurotomy of the peripheral nerves on the upper limb makes it possible to optimize the result of tone-lowering treatment because of the accurate selection and exact category of patients in whom neurosurgical treatment can be effective. AIM: To assess the prognostic effectiveness of diagnostic blockade for modeling the result of selective neurotomy of the motor branches of the musculocutaneous nerve in patients with cerebral palsy. MATERIALS AND METHODS: This longitudinal prospective study included an examination of 31 patients aged 517 years with spastic forms of cerebral palsy. Before neurosurgical treatment, each patient underwent a diagnostic blockade of the n. musculocutaneus under ultrasonography and neurostimulation. Before and after the diagnostic blockade and after the neurosurgical treatment, each patient was examined for the amplitude of passive and active joint movements, muscle tone, hand functionality, and dynamometry. RESULTS: Results of the data analysis showed a significant relationship between the state of the elbow joint during the simulation of surgical treatment and after neurosurgical treatment. CONCLUSIONS: The study showed the high prognostic effectiveness of diagnostic blockades when deciding on the techniques of treating tonic flexion contractures of the elbow joint as part of the spastic arm syndrome. The diagnostic blockade of the musculocutaneous nerve during the planning of surgical treatment makes it possible to create a reliable temporal model of selective neurotomy of the motor nerve branches.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
    detail.hit.zdb_id: 3046142-X
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  • 5
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2019
    In:  Pediatric Traumatology, Orthopaedics and Reconstructive Surgery Vol. 7, No. 1 ( 2019-04-06), p. 71-80
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 7, No. 1 ( 2019-04-06), p. 71-80
    Abstract: Introduction. The task of preserving the psychological health of children and adolescents is recognized as most important in the complex conditions of the modern world. Interdisciplinary research addresses the psychological aspects of mental health. For psychological health, understanding the highest level of mental health is an integral characteristic of the well-being of the individual, and the prerequisites for the development of personal maturity. Among the adverse factors in relation to mental and psychological health is what is known as somatic suffering, which occurs in orthopedic diseases. Cognitive, emotional, and behavioral responses to orthopedic disease, eliminating maladaptive manifestations in difficult life situations due to the disease, can be important indicators of psychological health of adolescents. Aim. We identify specific indicators of psychological health in adolescents with various orthopedic diseases. Materials and methods. The study involved 90 adolescents: 60 aged 1217 years with orthopedic diseases (30 with articular juvenile chronic arthritis and 30 with long-term consequences of mechanical trauma of the upper and lower limbs, resulting from an accident due to negligence) and a control group consisting of healthy adolescents of the same age. The characteristics of the self-esteem personality component (satisfaction with various aspects of their own lives) in adolescents with orthopedic diseases and their healthy peers were considered traditional indicators of psychological health. We used PiersHarris scale modified by V.I. Gordeev Y.S. Aleksandrovich and test of attitude to disease. Results. In adolescents with various forms of orthopedic disorders, the formation of stable variants of the attitude to the disease with a violation of adaptation of inter- and intrapsychic types is accompanied by the experience of discomfort, difficulties of self-regulation during treatment, and signs of a negative attitude. Formation of stable variants of emotional, cognitive, and behavioral responses without expressed disorders of mental and social adaptation is accompanied by a feeling of comfort and self-satisfaction. The prevailing reaction at harmonic, allopathic, and anosognosic types of mogutt act as a sanogenic effect. Emerging resistant variants of the attitude to the disease with a violation of adaptation of inter- and intrapsychic types can represent risk factors for breach of psychological health in adolescents with orthopedic diseases.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2019
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  • 6
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2022
    In:  Pediatric Traumatology, Orthopaedics and Reconstructive Surgery Vol. 10, No. 4 ( 2022-12-25), p. 459-470
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 10, No. 4 ( 2022-12-25), p. 459-470
    Abstract: BACKGROUND: Sacral neuromodulation is a neurosurgical method for the correction of bladder and bowel dysfunctions of various origins that are refractory to conservative treatment. AIM: To analyze chronic sacral neurostimulation results as a correction method for pediatric bladder and bowel dysfunction of various origins. MATERIALS AND METHODS: The results of chronic sacral neurostimulation for treating urination and defecation disorders of various origins in children reported in the world literature were analyzed. The literature search was performed in the open electronic scientific databases eLIBRARY, PubMed, and Cochrane Library. The source selection was limited by 20022022. RESULTS: Most authors report good and satisfactory results in the treatment of bladder and bowel dysfunction by sacral neurostimulation. However, the level of evidence on the effectiveness of sacral neurostimulation remains low because data were obtained from small and heterogeneous groups of patients and studies employed different criteria for inclusion and methods for analyzing the results. CONCLUSIONS: Conducting randomized trials will allow for the assessment of the efficacy and safety of sacral neuromodulation in children with bladder and bowel dysfunctions of various origins that are refractory to standard conservative treatment.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3046142-X
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  • 7
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 11, No. 2 ( 2023-07-05), p. 149-158
    Abstract: BACKGROUND:Posture disorders and spinal deformity in the sagittal plane (kyphotic deformity of the thoracic region and lumbar hyperlordosis in combination with pelvic inclination) are quite common in patients with cerebral palsy. However, their relationship with the frontal indicators of the hip joint is not reported in the scientific literature. AIM:To reveal the relationship between the radiographic frontal indicators of the hip joint and the indicators of the spinal-pelvic sagittal balance in patients with cerebral palsy. MATERIALS AND METHODS:Atransverse study of the X-ray parameters of the hip joints in the frontal plane and sagittal vertebral-pelvic profile was performed in 46 patients with cerebral palsy aged 515 (mean age, 8.2 3.6) years. RESULTS:Asignificant difference from the norm was found in the following parameters: cervical-diaphyseal angle, pelvic tilt angle, pelvic tilt angle, sacral tilt angle, thoracic kyphosis, lumbar lordosis, and sagittal vertical axis deviation (p 0.05). The Sharp angle, migration index, Wiberg angle, and thoracic kyphosis were normal. Measurements of the frontal radiographic parameters of the right and left hip joints do not differ significantly from each other. The pelvic tilt showedapositive and strong correlation with pelvic tilt (p= 0.71).Apositive and moderate correlation was found determined betweenasequential chain of related elements of the axial skeleton, namely, sacral inclination-lumbar lordosis (p= 0.66) and lumbar lordosis-thoracic kyphosis (p= 0.41). The deviation of the sagittal vertical axis negatively correlated with lumbar lordosis (p= 0.69) and thoracic kyphosis (p= 0.38). The results demonstrateanegative and weak correlation between SDA and sacral tilt (p= 0.40). CONCLUSIONS:The results of this study indicateacorrelation between the inclination of the sacrum and the lumbar spine in patients with cerebral palsy, which confirms the main theories of the formation of excessive lumbar lordosis of the spine in these patients and allows us to develop pathogenetic preventive measures against spinal deformities. In this study, we failed to identifyasignificant relationship between the frontal radiographic parameters of the hip joint and sagittal pelvic-vertebral profile. However, hip joint instability inachild with cerebral palsy can playasignificant role in the occurrence and development of sagittal spinal deformities.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
    detail.hit.zdb_id: 3046142-X
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  • 8
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2018
    In:  Pediatric Traumatology, Orthopaedics and Reconstructive Surgery Vol. 6, No. 4 ( 2018-12-29), p. 103-109
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 6, No. 4 ( 2018-12-29), p. 103-109
    Abstract: Introduction. New questions of indications and methods of surgical treatment of children with congenital spinal deformity are covered in detail. However, straightening deformed segment of the spine and fixing with metal construction is not sufficient, and conditions for its retention and prevention of migration must be created. The expediency of the study is relevant because of lack of systematic review of the results of orthotic support as complex treatment of this group of patients, both in Russia and abroad. The problems faced by vertebral surgeons are the following: the tendency of deformation relapse as the child grows, tendency of deformation of unfixed (lower and upper) segments of the vertebral column. Clinical case. For observation, we selected an 11-year-old patient. The diagnosis was congenital scoliosis on posterolateral hemivertebra Th4, dysplastic course of congenital spinal deformity. The surgical treatment performed was extirpation of hemivertebra Th4(S) and the correction of local congenital deformity with multicore corrective system in combination with bone grafting. We achieved complete correction of congenital local curve at the level of the posterior lateral hemivertebra and reduction of compensatory curves in the thoracic and lumbar spine. In the postoperative period, the patient was provided with corrective brace, with the aim of influencing on the compensatory curve. Discussion. This clinical observation aimed to determine the different approaches to treatment of children with congenital deformities of the thoracic spine, which consists of surgical correction of local congenital curvature curve with subsequent correction of compensatory curves by using a correcting brace. Conclusion. As a result of the surgical intervention, correction of congenital spinal deformity was achieved, and the use of a corrective brace in the postoperative period allowed the correction of compensatory curves and maintained the achieved result until the end of the patient’s growth.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2018
    detail.hit.zdb_id: 3046142-X
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  • 9
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2021
    In:  Pediatric Traumatology, Orthopaedics and Reconstructive Surgery Vol. 9, No. 1 ( 2021-03-15), p. 5-16
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 9, No. 1 ( 2021-03-15), p. 5-16
    Abstract: BACKGROUND: Due to the spread of the novel coronavirus infection (COVID-19) and the introduction of restrictive measures to prevent its spread, there has been a change in the organization and work of medical institutions. New rules for admitting patients with injuries, limiting hospitalization of planned patients, examining patients for coronavirus infection, examining parents of children with injuries, conducting remote consultations, and identifying areas without COVID-19 for repeated outpatient care have been introduced in trauma centers and hospitals. New conditions for the organization and functioning of outpatient and inpatient departments have had an impact on the picture of child trauma. AIM: This study aims to conduct a comparative analysis of the level and nature of musculoskeletal injuries in children who sought medical care during the COVID-19 pandemic and injuries that occurred during the same period of the previous year. MATERIALS AND METHODS: The analysis of the medical history data of 3820 patients aged 0 to 17 years, who were admitted to the City Center for Outpatient Surgery and Trauma of St. Petersburg St. Mary Magdalene Childrens City Hospital No. 2 during the period from March 16, 2020, to May 31, 2020, and for the same period in 2019. RESULTS: The number of initial visits with trauma in 2019 was 2851 patients, whereas during the same period in 2020, 969 patients came with trauma. In general, during the study period in 2020, the trauma rate decreased by 66% compared with the same period in 2019. Despite the general decrease in the level of injuries in the study period in 2020, in the injured structures of the musculoskeletal system, the proportion of limb fractures was 35% and exceeded the same indicator in 2019 (p = 0.004, 2 criterion). In 2020, the level of street injuries (p 0.0001) decreased by 83%, while there was a 61% increase in domestic injuries (p 0.0001) and a 47% increase in traffic injuries (p 0.0001). CONCLUSION: The relationship between the outbreak of a pandemic and a decrease in the number of visits to the trauma center of Childrens Hospital No. 2 was revealed and a change in the structure of injuries depending on their cause. This change may be associated with restrictive measures, the transfer to distance learning, the ban on organized sports events, and the reduced usage of playgrounds. This information can be useful for planning the work of health authorities and distributing resources during future pandemic situations.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2021
    detail.hit.zdb_id: 3046142-X
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  • 10
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2022
    In:  Pediatric Traumatology, Orthopaedics and Reconstructive Surgery Vol. 10, No. 2 ( 2022-07-12), p. 143-150
    In: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery, ECO-Vector LLC, Vol. 10, No. 2 ( 2022-07-12), p. 143-150
    Abstract: BACKGROUND: Among the orthopedic consequences of cerebral palsy, instability of the hip joints is one of the most common. Most children with cerebral palsy at birth have close to normal relationships in their hip joints that gradually deteriorates. Progressive instability of the hip joint leads to subluxation and then dislocation of the hip, to a decrease in the range of motion in the joints, to movement disorders and a defect in the ability to sit, as well as an impairment in hygienic care of the child. AIM: To analyze the X-ray anatomical structure of the acetabulum in unstable hip joint in children with cerebral palsy. MATERIALS AND METHODS: We examined 42 hip joints in 23 patients with cerebral palsy. Participants were divided into two groups. The main group included the results of the examination of unstable hip joints (31 studies), and the control group included the results of the examination of stable joints (11 studies). RESULTS: The average index of anteversion of the acetabulum in the main group with a functioning Y-shaped cartilage was 2.5 more than the average value of the norm (p = 0.029), with a nonfunctioning Y-shaped cartilage at 6 less than the normal value (p = 0.017). There was a positive moderate correlation between the anteversion of the acetabulum and the anterior margin angle (r = 0.424, p = 0.017), and a positive moderate correlation between the acetabular index and the anterior margin angle (r = 0.398, p = 0.027). CONCLUSIONS: The study showed that changes in the acetabulum in patients with pathological dislocation or subluxation of the hip against the background of spastic cerebral palsy were manifested by deformation in the horizontal plane due to retroversion of the acetabulum.
    Type of Medium: Online Resource
    ISSN: 2410-8731 , 2309-3994
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3046142-X
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