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  • 1
    In: Blood, American Society of Hematology, Vol. 140, No. Supplement 1 ( 2022-11-15), p. 2159-2160
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
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    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2022
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  • 2
    In: Blood, American Society of Hematology, Vol. 138, No. Supplement 1 ( 2021-11-05), p. 838-838
    Abstract: Background: The use of virtual care rapidly increased during the COVID-19 pandemic to provide adequate care for patients while minimizing contact. Studies in solid tumors show high rates of patient satisfaction with virtual care as well as cost-savings. However, little is known about the application of virtual care in malignant hematology, which includes a heterogenous population of patients often at increased risk of infection. Understanding when virtual care or a hybrid model can be used is crucial for comprehensive patient care. Methods: A retrospective review of patients with hematologic malignancies receiving care at Princess Margaret (PM) Cancer Centre in Toronto, Canada from October 2019 to March 2021 was performed. The primary objective was to describe the use of virtual care at three time points: prior to the pandemic, during the initial months of the pandemic, and beyond the initial months. Patients were included in the analysis if they had a clinical visit for their hematologic malignancy. Patients were excluded if they were presenting for treatment-related visits or blood count checks. All methods of virtual care, including phone visits and teleconferencing, were included in the analysis. Patient satisfaction with virtual care was assessed using responses to the Your Voice Matters survey administered from September 2020 to April 2021, a provincial survey of patient-reported experience. Results: A total of 93472 visits for 23162 patients were identified at PM from October 2019 to March 2021 (55% of visits for ambulatory clinic appointments). Mean age was 60 years (range 18-103 years) and 45% of patients were female (N = 23162). Ambulatory clinic appointments for new consultation or follow-up care were done in the following clinics: autologous or allogeneic bone marrow transplant (21%, N = 10 747), cellular therapy (0.2%, N = 82), leukemia (26%, N = 13419), lymphoma (32%, N = 16427) and myeloma (21%, N = 10711). From October 2019 to March 2020, there were 14512 visits, of which nearly 100% were in-person (N = 14511). From March 1 2020 to September 1 2020, there were 19179 total visits, of which 36% were virtual, with the majority of visits by phone (6325 phone visits and 567 video visits). From September 1 2020 to March 1 2021, there was a small decrease in the use of virtual care (p & lt;0.01), but utilization of phone and video visits continued to be used for 30% of patients (N=17695 total visits; 4964 phone visits and 327 video visits). Virtual care was most often used for patients with myeloma (46%) or lymphoma (36%), as shown in Figure 1. A total of 75 survey responses for patients with hematologic malignancies followed at PM were available. 67 responses (89.3%) were from patients, with the remaining from caregivers. 47 visits (62.7%) were in-person, 26 visits (34.7%) were virtual, and 2 visits (2.7%) did not have the visit type available. Survey results are shown in Table 1.Results for in-person and virtual visits were very similar, with both groups reporting that their provider listened to their concerns and involved them in making treatment decisions. There was a trend toward providers discussing physical symptoms more for patients who had virtual visits (mean score of 4.73/5 for virtual visit compared to a mean score of 4.36/5, p=0.10). Data on next visit type preference was available for 25 patients who had a virtual visit and 46 patients who had an in-person visit. For patients who had a virtual visit, 36% preferred a repeat virtual visit with 56% having no preference and only 7.7% preferring an in-person visit. For patients who had an in-person visit, 33% preferred their next visit to be virtual, with only 24% preferring their next visit to be in-person and the remaining 43% having no preference. Conclusion: The use of virtual care increased substantially during the COVID-19 pandemic and persisted into 2021 with high rates of patient and provider satisfaction. The highest uptake of virtual care was for patients with myeloma or lymphoma. There were no significant differences in patient satisfaction scores for virtual visits compared to in-person visits, and one third of patients preferred a virtual visit after an in-person visit. These findings suggest that virtual care is a feasible and preferred tool for delivering care to a substantial proportion of patients with hematologic malignancies. Further work is needed to determine how to optimally integrate virtual care for specific patient populations. Figure 1 Figure 1. Disclosures Prica: Astra-Zeneca: Honoraria; Kite Gilead: Honoraria.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
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    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2021
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  • 3
    In: Pain Research and Management, Hindawi Limited, Vol. 17, No. 4 ( 2012), p. 291-296
    Abstract: BACKGROUND: Painful vaso-occlusive crisis (VOC) is the most common reason for hospitalization in children with sickle cell disease. OBJECTIVE: To benchmark pain outcomes in sickle cell disease, including process outcomes (eg, pain assessment and documentation practices, pain management interventions) and clinical outcomes (eg, pain intensity over hospital stay), to identify areas for improvement. METHODS: A retrospective study was conducted on electronic charts of children hospitalized with a primary diagnosis of VOC between July 2007 and August 2008. RESULTS: A convenience sample of 50 admissions was used. In terms of clinical outcomes, patients presented to the emergency department with an initial median pain intensity of 9/10 (interquartile range 8/10 to 10/10). Forty-three per cent had not used opioids for pain relief at home. The mean (± SD) length of stay was 4.0±2.3 days. For most patients, median scores for highest daily pain intensity remained moderate to high throughout hospitalization, although scores did decrease significantly per day of hospitalization. In terms of process outcomes, pain intensity was assessed according to hospital standards on 25% of days in both the emergency department and the ward. There was no discrepancy between prescribed and administered opioid doses and medication use. In 95% of cases, strong opioid use was in a subtherapeutic or low therapeutic dosage range. CONCLUSIONS: The results showed three areas to target for improvement: improved pain assessment and documentation using valid pain tools; more aggressive multimodal management for peak VOC pain; and better education and support for pain management at home. Further studies are required to evaluate optimal pain treatment practices.
    Type of Medium: Online Resource
    ISSN: 1203-6765
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2048409-4
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  • 4
    Online Resource
    Online Resource
    American Medical Association (AMA) ; 2015
    In:  JAMA Internal Medicine Vol. 175, No. 6 ( 2015-06-01), p. 891-
    In: JAMA Internal Medicine, American Medical Association (AMA), Vol. 175, No. 6 ( 2015-06-01), p. 891-
    Type of Medium: Online Resource
    ISSN: 2168-6106
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2015
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  • 5
    In: Telemedicine and e-Health, Mary Ann Liebert Inc, Vol. 18, No. 4 ( 2012-05), p. 271-276
    Type of Medium: Online Resource
    ISSN: 1530-5627 , 1556-3669
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2012
    detail.hit.zdb_id: 1480735-X
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  • 6
    In: Blood, American Society of Hematology, Vol. 140, No. Supplement 1 ( 2022-11-15), p. 8028-8029
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2022
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 7
    In: Pediatric Blood & Cancer, Wiley, Vol. 63, No. 12 ( 2016-12), p. 2250-2251
    Type of Medium: Online Resource
    ISSN: 1545-5009 , 1545-5017
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2130978-4
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  • 8
    In: JAMA Oncology, American Medical Association (AMA), Vol. 9, No. 3 ( 2023-03-01), p. 386-
    Abstract: Patients with cancer are known to have increased risk of COVID-19 complications, including death. Objective To determine the association of COVID-19 vaccination with breakthrough infections and complications in patients with cancer compared to noncancer controls. Design, Setting, and Participants Retrospective population-based cohort study using linked administrative databases in Ontario, Canada, in residents 18 years and older who received COVID-19 vaccination. Three matched groups were identified (based on age, sex, type of vaccine, date of vaccine): 1:4 match for patients with hematologic and solid cancer to noncancer controls (hematologic and solid cancers separately analyzed), 1:1 match between patients with hematologic and patients with solid cancer. Exposures Cancer diagnosis. Main Outcomes and Measures Outcomes occurring 14 days after receipt of second COVID-19 vaccination dose: primary outcome was SARS-CoV-2 breakthrough infection; secondary outcomes were emergency department visit, hospitalization, and death within 4 weeks of SARS-CoV-2 infection (end of follow-up March 31, 2022). Multivariable cumulative incidence function models were used to obtain adjusted hazard ratio (aHR) and 95% CIs. Results A total of 289 400 vaccinated patients with cancer (39 880 hematologic; 249 520 solid) with 1 157 600 matched noncancer controls were identified; the cohort was 65.4% female, and mean (SD) age was 66 (14.0) years. SARS-CoV-2 breakthrough infection was higher in patients with hematologic cancer (aHR, 1.33; 95% CI, 1.20-1.46; P   & amp;lt; .001) but not in patients with solid cancer (aHR, 1.00; 95% CI, 0.96-1.05; P  = .87). COVID-19 severe outcomes (composite of hospitalization and death) were significantly higher in patients with cancer compared to patients without cancer (aHR, 1.52; 95% CI, 1.42-1.63; P   & amp;lt; .001). Risk of severe outcomes was higher among patients with hematologic cancer (aHR, 2.51; 95% CI, 2.21-2.85; P   & amp;lt; .001) than patients with solid cancer (aHR, 1.43; 95% CI, 1.24-1.64; P   & amp;lt; .001). Patients receiving active treatment had a further heightened risk for COVID-19 severe outcomes, particularly those who received anti-CD20 therapy. Third vaccination dose was associated with lower infection and COVID-19 complications, except for patients receiving anti-CD20 therapy. Conclusions and Relevance In this large population-based cohort study, patients with cancer had greater risk of SARS-CoV-2 infection and worse outcomes than patients without cancer, and the risk was highest for patients with hematologic cancer and any patients with cancer receiving active treatment. Triple vaccination was associated with lower risk of poor outcomes.
    Type of Medium: Online Resource
    ISSN: 2374-2437
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    American Society of Clinical Oncology (ASCO) ; 2023
    In:  American Society of Clinical Oncology Educational Book , No. 43 ( 2023-05)
    In: American Society of Clinical Oncology Educational Book, American Society of Clinical Oncology (ASCO), , No. 43 ( 2023-05)
    Abstract: COVID-19 and our armamentarium of strategies to combat it have evolved dramatically since the virus first emerged in late 2019. Vaccination remains the primary strategy to prevent severe illness, although the protective effect can vary in patients with hematologic malignancy. Strategies such as additional vaccine doses and now bivalent boosters can contribute to increased immune response, especially in the face of evolving viral variants. Because of these new variants, no approved monoclonal antibodies are available for pre-exposure or postexposure prophylaxis. Patients with symptomatic, mild-to-moderate COVID-19 and risk features for developing severe COVID-19, who present within 5-7 days of symptom onset, should be offered outpatient therapy with nirmatrelvir/ritonavir (NR) or in some cases with intravenous (IV) remdesivir. NR interacts with many blood cancer treatments, and reviewing drug interactions is essential. Patients with severe COVID-19 should be managed with IV remdesivir, tocilizumab (or an alternate interleukin-6 receptor blocker), or baricitinib, as indicated based on the severity of illness. Dexamethasone can be considered on an individual basis, weighing oxygen requirements and patients' underlying disease and their perceived ability to clear infection. Finally, as CD19-targeted and B-cell maturation (BCMA)–targeted chimeric antigen receptor (CAR) T-cell therapies become more heavily used for relapsed/refractory hematologic malignancies, viral infections including COVID-19 are increasingly recognized as common complications, but data on risk factors and prophylaxis in this patient population are scarce. We summarize the available evidence regarding viral infections after CAR T-cell therapy.
    Type of Medium: Online Resource
    ISSN: 1548-8748 , 1548-8756
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2023
    detail.hit.zdb_id: 2431126-1
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  • 10
    Online Resource
    Online Resource
    Elsevier BV ; 2020
    In:  The Lancet Haematology Vol. 7, No. 2 ( 2020-02), p. e146-e156
    In: The Lancet Haematology, Elsevier BV, Vol. 7, No. 2 ( 2020-02), p. e146-e156
    Type of Medium: Online Resource
    ISSN: 2352-3026
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
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