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  • 1
    In: Revista Baiana de Saúde Pública, Secretaria da Saude do Estado da Bahia, Vol. 40, No. 4 ( 2017-12-02)
    Abstract: A exposição a material biológico por acidente é um fato um tanto quanto frequente em acidentes de trabalho envolvendo profissionais de saúde, figurando como um risco para a saúde do profissional e do paciente, posto que o material é potencialmente infectante e por indicar a possibilidade de soroconversão. O objetivo desse estudo foi analisar os acidentes ocupacionais com exposição a material biológico envolvendo profissionais de saúde no Hospital Geral Clériston Andrade no município de Feira de Santana. Teve como método o estudo do tipo corte transversal, de abordagem quantitativa, sendo utilizadas as notificações de acidentes ocupacionais com exposição a material biológico envolvendo profissionais de saúde que foram notificados no hospital em estudo nos anos de 2011 e 2012. Foram analisados 254 acidentes. Os resultados indicaram que a categoria profissional mais acometida foi a dos técnicos e auxiliares de enfermagem (47,6%). A maioria dos acidentes ocorreram durante punções (21,3%); quanto à situação vacinal, 88,1% estavam devidamente vacinados. Com isso, concluiu-se que é importante a implantação de estratégias que visem a capacitar os profissionais na notificação, no uso de medidas profiláticas e nas condutas a serem tomadas frente aos acidentes com exposição a material biológico. Palavras-chave: Acidentes de trabalho. Riscos ocupacionais. Pessoal de saúde.
    Type of Medium: Online Resource
    ISSN: 2318-2660 , 0100-0233
    URL: Issue
    Language: Unknown
    Publisher: Secretaria da Saude do Estado da Bahia
    Publication Date: 2017
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  • 2
    In: TAXON, Wiley, Vol. 71, No. 1 ( 2022-02), p. 178-198
    Abstract: The shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis , concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora.
    Type of Medium: Online Resource
    ISSN: 0040-0262 , 1996-8175
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    detail.hit.zdb_id: 204216-2
    SSG: 12
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  • 3
    In: Sports Biomechanics, Informa UK Limited, Vol. 22, No. 9 ( 2023-09-02), p. 1108-1119
    Type of Medium: Online Resource
    ISSN: 1476-3141 , 1752-6116
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2098824-2
    SSG: 31
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  • 4
    Online Resource
    Online Resource
    Editora e Distribuidora Educacional ; 2023
    In:  Jornal Internacional de Estudos em Educação Matemática Vol. 15, No. 3 ( 2023-01-23), p. 364-372
    In: Jornal Internacional de Estudos em Educação Matemática, Editora e Distribuidora Educacional, Vol. 15, No. 3 ( 2023-01-23), p. 364-372
    Abstract: O presente trabalho tem como objetivo compreender qual o espaço ocupado pelas mulheres nas ciências exatas e em especial na Matemática, bem como os desafios e possibilidades para sua formação docente. Justifica-se pela necessidade de legitimar a participação feminina na construção do saber matemático, de modo a fortalecer a inserção e permanência das mulheres nos cursos de Licenciatura e Bacharelado em Matemática. Para tanto, a pesquisa de abordagem qualitativa, configura-se como uma revisão bibliográfica. O levantamento das produções foi realizado na BDTD, Biblioteca Digital Brasileira de Teses e Dissertações, e na Plataforma Sucupira, as palavras-chaves norteadoras da busca foram matemática e mulheres e resultou em 17 pesquisas, entre dissertações e teses. Mediante a leitura dos trabalhos coletados e da identificação das relações por eles estabelecidas, foram formulados três eixos de análise: 1. Trajetória e participação das mulheres no desenvolvimento da Ciência; 2. Inserção, formação inicial e atuação feminina na docência em Matemática; 3. Relações de Gênero nas aulas de Matemática. Observou-se que prevalece no campo da produção científica uma relação de competitividade que assegura aos homens a hegemonia do conhecimento, à medida que inviabiliza a legitimação da mulher cientista. No âmbito da Matemática o preconceito persistente, apresenta-se, muitas vezes, de maneira velada e conduz as mulheres a negarem sua feminilidade para conquistarem respeito e respaldo no exercício da profissão. Ainda assim, a presença feminina nas salas de aulas marca não só a evolução da sociedade, mas também a oportunidade de fortalecimento do processo de ensino e de aprendizagem da Matemática. Palavras-chaves: Mulheres. Matemática. Docência. Formação Inicial. AbstractThis work aims to understand the space occupied by women in exact sciences and especially in Mathematics, as well as the challenges and possibilities for their teacher education. It is justified by the need to legitimize female participation in the construction of mathematical knowledge, to strengthen the insertion and permanence of women in Licentiate and Bachelor of Mathematics courses. Therefore, the qualitative approach research is configured as a literature review. The survey of productions was conducted at the BDTD, Brazilian Digital Library of Theses and Dissertations, and at Plataforma Sucupira, the guiding keywords for the search were Mathematics and women and resulted in 17 studies, including dissertations and theses. From the reading of the collected works and the identification of the relationships established by them, three axes of analysis were developed: 1. The trajectory and participation of women in the development of Science; 2. Insertion, initial training and female performance in Mathematics teaching; 3. Gender Relations in Mathematics classes. It was observed that a competitive relationship prevails in the field of scientific production that assure men the hegemony of knowledge, as it makes the legitimacy of female scientists unfeasible. In the field of Mathematics, persistent prejudice is often presented in a veiled way and leads women to deny their femininity to gain respect and support in the exercise of their profession. Even so, the presence of women in classrooms marks not only the evolution of society but also the opportunity to strengthen the teaching and learning process of Mathematics. Keywords: Women. Math. Teaching. Initial Formation.
    Type of Medium: Online Resource
    ISSN: 2176-5634
    URL: Issue
    Language: Unknown
    Publisher: Editora e Distribuidora Educacional
    Publication Date: 2023
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  • 5
    In: Journal of Sport and Health Science, Elsevier BV, Vol. 9, No. 2 ( 2020-03), p. 152-159
    Type of Medium: Online Resource
    ISSN: 2095-2546
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
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    SSG: 31
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  • 6
    In: Blood, American Society of Hematology, Vol. 138, No. Supplement 1 ( 2021-11-05), p. 4843-4843
    Abstract: Introduction: Treatment of diffuse large B cell lymphoma (DLBCL) may be a challenge for Latin American countries. Thus, novel strategies to reduce the economic burden of oncological care are necessary. In Brazil, the DLBCL annual incidence is approximately 6.000 cases, among which 30% will relapse or become refractory (R/R). In this scenario, the limited access to the new therapies reinforce the need to develop new local technologies and improve research initiatives. Here we report the development and clinical application of a Brazilian platform to manufacture genetically modified T-cells to treat patients with R/R leukemia and lymphomas, which may also help reverse the poor prognosis of these patients in low and middle-income countries. Patients and Methods: All patients were referred to our center to consider compassionate use of anti-CD19 CAR-T cell therapy. The treatment was authorized by the local medical ethical committee. Once patients were deemed to be eligible for CAR-T, they were scheduled for lymphopheresis and the cells were processed and cryopreserved. During the manufacturing process and after completion of lymphophersis, all three patients received bridging therapy. Prior to infusion of CAR-T, patients were given lymphodepletion chemotherapy with cyclophosphamide and fludarabine for 3 days. Patients were monitored daily for the occurrence of cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS), which were graduated according to the criteria of the American Society for Transplantation and Cellular Therapy. These treatments were only available because we developed a Brazilian platform to manufacture genetically modified T-cells. Firstly, we developed and validated in vitro and in vivo anti-CD19 CAR T cell expression, expansion, and cytotoxicity. Secondly, in-house lentiviral good-manufacturing practice (GMP) protocols were established for clinical purposes. Thirdly, we upscaled the manufacturing process into the GMP facility originally developed for MSCs and adapted it to genetically modified T-cells. Finally, in-house procedures to deliver anti-CD19 CAR T cells for clinical use were established according to the Brazilian Health Regulatory Agency (ANVISA) policies. Once these steps were implemented, we were able to treat the first three patients of a patient with CAR-T cells produced in Latin America. Results: Two patients presented CAR-T cell expansion after the procedure (Figure 1). Within thirty days after the infusion one patient achieved complete response, one had partial response and one was not evaluated (Table 1). All patients had CRS and only one had ICANS. Two patients died, one from infection and other from intracranial hemorrhage due to domestic accident, --- and --- days after CAR-T cell infusion, respectively. Discussion: At least two of the reported patients presented improvement of their disease. The other one died before the expected response could have been evaluated. None of the patients died from complications related to manufacturing or infusion procedures, highlighting an acceptable safety profile of the platform. Although these are preliminary results, the CAR-T cell expansion profile, presence of systemic inflammatory response and lack of early disease progression suggest the treatment effectiveness. Conclusion: Apart from all the scientific challenges, this experience highlights the feasibility to implement a viable and efficient CAR-T platform in middle-income countries. Besides, implementation of advanced cellular therapy can also contribute to enhancing the quality of other cellular therapies. Figure 1 Figure 1. Disclosures Guerino-Cunha: Novartis: Other: Speaker; BMS: Other: Speaker; Janssen: Other: Speaker. Calado: Instituto Butantan: Consultancy; Alexion Brasil: Consultancy; Team Telomere, Inc.: Membership on an entity's Board of Directors or advisory committees; Novartis Brasil: Honoraria; Agios: Membership on an entity's Board of Directors or advisory committees; AA & MDS International Foundation: Research Funding.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2021
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    detail.hit.zdb_id: 80069-7
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  • 7
    In: Revista de Enfermagem UFPE on line, Revista de Enfermagem, UFPE Online, Vol. 13, No. 2 ( 2019-02-09), p. 491-
    Abstract: RESUMOObjetivo: analisar o dimensionamento de pessoal de Enfermagem frente à qualidade da assistência. Método: trata-se de um estudo bibliográfico, tipo revisão integrativa, de artigos publicados no período de 2007 a 2017, nas bases de dados MEDLINE, LILACS e BDENF. Apresentaram-se as sínteses dos resultados dos artigos em figuras. Resultados: identificaram-se, na busca inicial, 103 publicações. Selecionaram-se 11 artigos a partir da análise do título, da temática pesquisada e dos critérios de elegibilidade e, na leitura na íntegra dos conteúdos, restaram três, sendo dois de abordagem metodológica qualitativa e uma de abordagem quantitativa. Destaca-se que os descritores mais utilizados pelos autores dos artigos foram cuidados de Enfermagem, dimensionamento de pessoal, qualidade da assistência à saúde, sendo o campo de pesquisa desses estudos o dimensionamento de pessoal de Enfermagem. Conclusão: pode-se considerar que o dimensionamento de pessoal é uma etapa importante, que direciona a assistência da equipe de Enfermagem, de modo que ela reconheça a necessidade de planejar estratégias para identificar o perfil dos pacientes atendidos e a necessidade de profissionais para assisti-los. Descritores: Cuidados de Enfermagem; Dimensionamento Pessoal; Qualidade da Assistência à Saúde; Recursos Humanos; Profissionais de Enfermagem; Competência Profissional.ABSTRACT Objective: to analyze the nursing staff dimensioning the quality of care. Method: this is a bibliographical study, an integrative review, of articles published in the period 2007 to 2017, in the MEDLINE, LILACS and BDENF databases. The articles were read and the summaries of the results of the articles in figures. Results: 103 publications were identified in the initial search. Eleven articles were selected from the analysis of the title, the researched topic and the eligibility criteria, and three contents remained in the reading of the contents, two of which were qualitative and one quantitative approach. It should be highlighted that the descriptors most used by the authors of the articles were Nursing care, personnel dimensioning, quality of health care, being the field of research of these studies the dimensioning of Nursing staff. Conclusion: it can be considered that the personnel dimension is an important step, which directs the assistance of the Nursing team, so that it recognizes the need to devise strategies to identify the profile of patients attended and the need for professionals to assist them. Descritores: Nursing Care; Personnel Downsizing; Quality of Health Care; Human Resources; Nurse Practitioners; Competence Professional.RESUMEN Objetivo: analizar el dimensionamiento de personal de enfermería frente a la calidad de la asistencia. Método: se trata de un estudio bibliográfico, tipo revisión integrativa, de artículos publicados en el período de 2007 a 2017, en las bases de datos MEDLINE, LILACS y BDENF. Se presentaron las síntesis de los resultados de los artículos en figuras. Resultados: se identificaron, en la búsqueda inicial, 103 publicaciones. Se seleccionaron 11 artículos a partir del análisis del título, de la temática investigada y de los criterios de elegibilidad y, en la lectura íntegra de los contenidos, quedaron tres, siendo dos de abordaje metodológico cualitativo y uno de abordaje cuantitativo. Se destaca que los descriptores más utilizados por los autores de los artículos fueron cuidados de Enfermería, dimensionamiento de personal, calidad de la asistencia a la salud, siendo el campo de investigación de esos estudios el dimensionamiento de personal de Enfermería. Conclusión: se puede considerar que el dimensionamiento de personal es una etapa importante, que dirige la asistencia del equipo de Enfermería, de modo que ella reconozca la necesidad de planificar estrategias para identificar el perfil de los pacientes atendidos y la necesidad de profesionales para asistirlos. Descritores: Atencíon de Enfermería; Reduccíon de Personal; Calidad de la Atencíon de Salud; Recursos Humanos; Enfermeras Practicantes; Competencia Profissional.
    Type of Medium: Online Resource
    ISSN: 1981-8963
    Language: Unknown
    Publisher: Revista de Enfermagem, UFPE Online
    Publication Date: 2019
    detail.hit.zdb_id: 2915854-0
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  • 8
    In: Cancers, MDPI AG, Vol. 15, No. 7 ( 2023-03-29), p. 2025-
    Abstract: Hemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle tissues; visceral hemangiosarcomas can affect the spleen, liver, heart, lungs, kidneys, oral cavity, bones, bladder, uterus, tongue, and retroperitoneum. Among domestic species, dogs are most affected by cutaneous HSA. Cutaneous HSA represents approximately 14% of all HSA diagnosed in this species and less than 5% of dermal tumors, according to North American studies. However, Brazilian epidemiological data demonstrate a higher prevalence, which may represent 27 to 80% of all canine HSAs and 13.9% of all skin neoplasms diagnosed in this species. Cutaneous HSA most commonly affects middle-aged to elderly dogs (between 8 and 15 years old), with no gender predisposition for either the actinic or non-actinic forms. The higher prevalence of cutaneous HSA in some canine breeds is related to lower protection from solar radiation, as low skin pigmentation and hair coverage lead to greater sun exposure. Actinic changes, such as solar dermatosis, are frequent in these patients, confirming the influence of solar radiation on the development of this neoplasm. There are multiple clinical manifestations of hemangiosarcoma in canines. The diagnostic approach and staging classification of cutaneous HSAs are similar between the different subtypes. The definitive diagnosis is obtained through histopathological analysis of incisional or excisional biopsies. Cytology can be used as a presurgical screening test; however, it has little diagnostic utility in cases of HSA because there is a high risk of blood contamination and sample hemodilution. Surgery is generally the treatment of choice for dogs with localized non-visceral HSA without evidence of metastatic disease. Recently, electrochemotherapy (ECT) has emerged as an alternative therapy for the local ablative treatment of different neoplastic types; the use of radiotherapy for the treatment of dogs with cutaneous HSA is uncommon. There is greater consensus in the literature regarding the indications for adjuvant chemotherapy in subcutaneous and muscular HSA; doxorubicin is the most frequently used antineoplastic agent for subcutaneous and muscular subtypes and can be administered alone or in combination with other drugs. Other therapies include antiangiogenic therapy, photodynamic therapy, the association of chemotherapy with the metronomic dose, targeted therapies, and natural products. The benefits of these therapies are presented and discussed. In general, the prognosis of splenic and cardiac HSA is unfavorable. As a challenging neoplasm, studies of new protocols and treatment modalities are necessary to control this aggressive disease.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
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  • 9
    In: Physical Therapy in Sport, Elsevier BV, Vol. 47 ( 2021-01), p. e4-
    Type of Medium: Online Resource
    ISSN: 1466-853X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2007802-X
    SSG: 31
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  • 10
    Online Resource
    Online Resource
    GN1 Sistemas e Publicacoes Ltd. ; 2022
    In:  ITEGAM- Journal of Engineering and Technology for Industrial Applications (ITEGAM-JETIA) Vol. 8, No. 35 ( 2022)
    In: ITEGAM- Journal of Engineering and Technology for Industrial Applications (ITEGAM-JETIA), GN1 Sistemas e Publicacoes Ltd., Vol. 8, No. 35 ( 2022)
    Type of Medium: Online Resource
    ISSN: 2447-0228
    Language: Unknown
    Publisher: GN1 Sistemas e Publicacoes Ltd.
    Publication Date: 2022
    detail.hit.zdb_id: 2856336-0
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