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  • 1
    Online Resource
    Online Resource
    Reliability, Validity, and Responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index for Elderly Patients with a Femoral Neck Fracture
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  The Journal of Bone and Joint Surgery-American Volume Vol. 97, No. 9 ( 2015-05), p. 751-757
    Details
    In: The Journal of Bone and Joint Surgery-American Volume, Ovid Technologies (Wolters Kluwer Health), Vol. 97, No. 9 ( 2015-05), p. 751-757
    Type of Medium: Online Resource
    ISSN: 0021-9355
    URL: Article
    DOI: 10.2106/JBJS.N.00542
    RVK:
    XA 52200.A
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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  • 2
    Online Resource
    Online Resource
    High-resolution solid-state carbon-13 NMR. Conformational studies of NADH and NAD+ model systems
    American Chemical Society (ACS) ; 1981
    In:  Journal of the American Chemical Society Vol. 103, No. 17 ( 1981-08), p. 5140-5146
    Details
    In: Journal of the American Chemical Society, American Chemical Society (ACS), Vol. 103, No. 17 ( 1981-08), p. 5140-5146
    Type of Medium: Online Resource
    ISSN: 0002-7863 , 1520-5126
    URL: Article
    DOI: 10.1021/ja00407a031
    RVK:
    VA 1120 ; VA 1752
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 1981
    detail.hit.zdb_id: 1472210-0
    detail.hit.zdb_id: 3155-0
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Secondary electron yield measurements of carbon covered multilayer optics
    Elsevier BV ; 2010
    In:  Applied Surface Science Vol. 257, No. 2 ( 2010-11), p. 354-361
    Details
    In: Applied Surface Science, Elsevier BV, Vol. 257, No. 2 ( 2010-11), p. 354-361
    Type of Medium: Online Resource
    ISSN: 0169-4332
    URL: Article
    DOI: 10.1016/j.apsusc.2010.06.075
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 2002520-8
    detail.hit.zdb_id: 52886-9
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  • 4
    Online Resource
    Online Resource
    Treatment patterns and overall survival for recurrent esophageal or gastroesophageal junctional cancer: A nationwide European population-based study.
    American Society of Clinical Oncology (ASCO) ; 2021
    In:  Journal of Clinical Oncology Vol. 39, No. 3_suppl ( 2021-01-20), p. 186-186
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 39, No. 3_suppl ( 2021-01-20), p. 186-186
    Abstract: 186 Background: Esophageal cancer has a high risk for recurrence after treatment with curative intent. This study describes the characteristics of patients with esophageal or gastroesophageal junctional cancer at the time of recurrence, treatment patterns and overall survival (OS) after recurrence. Methods: Patients selected from the nationwide Netherlands cancer registry had received a primary diagnosis of non-metastatic squamous cell carcinoma or adenocarcinoma of esophagus or gastroesophageal junction in 2015 or 2016 and experienced recurrence after primary treatment with curative intent. Curative intent was defined as receiving resection (with or without [neo]adjuvant therapy) or definitive chemoradiotherapy (dCRT) without surgery. Recurrence within or after six months was calculated from resection date or end of dCRT. OS was calculated from recurrence and analysed using Kaplan-Meier curves with Log-Rank test. Results: We identified 856 patients who presented with disease recurrence after potentially curative treatment with resection (75%) or dCRT (25%). At recurrence, the majority of patients were male (78%),the median age was 68 years and 77% of patients had adenocarcinoma. Twenty-six percent of patients had disease recurrence within six months after curative treatment. Eighteen percent of patients had locoregional recurrence only, 48% distant recurrence only and 33% both locoregional and distant recurrence. Among patients with a distant recurrence, 37% had metastases in non-regional lymph nodes, 31% in the liver and 30% in the lung. After disease recurrence, 29% of patients received systemic therapy (chemo- or targeted therapy), 5% chemoradiotherapy, 1% surgery and 66% best supportive care only. The most common systemic treatment regimen was CapOx/FOLFOX (54%) and13% of patients received a targeted agent: trastuzumab containing regimen (n = 26) or paclitaxel and ramucirumab (n = 5). Among all patients, the median OS from date of recurrence was 4.4 months. Patients with recurrence within six months had a poorer median survival (2.1 months) compared to patients with recurrence after six months (5.7 months; p 〈 0.001). Median OS in patients with locoregional recurrence only was 7.4 months, distant recurrence only was 4.0 months, and both locoregional and distant recurrence was 3.4 months (p 〈 0.001). Patients with prior primary treatment with resection had median OS of 4.2 months and patients with prior dCRT of 5.1 months (p = 0.605). Conclusions: The majority of patients had distant metastases at disease recurrence and a small proportion received systemic therapy after recurrence. Overall prognosis was poor, and survival outcomes were poorest among patients with recurrence within six months of initial curative treatment suggesting a worse biological tumor behaviour.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2021.39.3_suppl.186
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2021
    detail.hit.zdb_id: 2005181-5
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  • 5
    Online Resource
    Online Resource
    Real-world representativeness of patient-reported outcome measures of patients with esophagogastric cancer.
    American Society of Clinical Oncology (ASCO) ; 2023
    In:  Journal of Clinical Oncology Vol. 41, No. 4_suppl ( 2023-02-01), p. 319-319
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 41, No. 4_suppl ( 2023-02-01), p. 319-319
    Abstract: 319 Background: The use of patient reported outcome measures (PROMs) is a popular method to obtain real-world patient data in oncological research. However, PROMs rely on voluntary and active participation of patients and are therefore prone to selection bias. To investigate the suitability of PROMs as real-world data, we investigated the real-world representativeness of the Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP) registry with respect to the Dutch population of patients with esophagogastric cancer. Methods: We identified 2,575 patients in the POCOP registry and 13,702 in the nationwide population-based Netherlands Cancer Registry (NCR) from 2016-2021. We used Representativeness-indicators (R-indicators) to investigate the degree to which the POCOP registry and clinically relevant subgroups thereof, were a representative sample with respect to the population. R-indicators express the representativeness between 0 (not representative) and 1 (perfect representativeness). Calibration methods using inverse propensity weighting were used to correct potential differences between POCOP and the population estimates. Subsequently, median and 5-year overall survival were calculated and compared between patients in the POCOP registry and in the population, to investigate the representativeness in terms of survival. Results: Representativeness of the entire POCOP registry was 0.73 (95% CI: 0.71-0.74). The overall representativeness of palliative patients was higher than that of potentially curable patients (0.89 (0.87-0.90) and 0.70 (0.68-0.71), respectively). Representativeness of most clinical subgroups stratified to treatment was good; R-indicators ranged between 0.8 to 1.0. Median survival of the NCR, POCOP and calibrated POCOP was 19, 32, and 23 months, respectively. The 5-year overall survival of patients in the NCR, POCOP and calibrated POCOP was 26%, 36%, and 27%, respectively. Conclusions: The real-world representativeness of patients who participated in PROMs was good when we accounted for treatment. This shows that in the analysis of PROMs stratification to treatment groups can lead to generalizable results to the population. Using complete non-stratified PROMs, real-world representativeness was lower and calibration methods could be used to correct differences between patients in the PROMs and the population.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2023.41.4_suppl.319
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2023
    detail.hit.zdb_id: 2005181-5
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  • 6
    Online Resource
    Online Resource
    Survival expressed in best-case, typical and worst-case scenarios for patients with nonmetastatic esophagogastric cancer: A population-based study.
    American Society of Clinical Oncology (ASCO) ; 2022
    In:  Journal of Clinical Oncology Vol. 40, No. 4_suppl ( 2022-02-01), p. 259-259
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 4_suppl ( 2022-02-01), p. 259-259
    Abstract: 259 Background: In recent years new treatment options and the centralization of surgery have improved survival for patients with non-metastatic esophageal and gastric cancer. However, it is currently unknown which patients have mostly benefitted from these treatment advances. The aim of this study was to use population-based data to identify best-case, typical and worst-case scenarios in terms of survival time, and to assess if the survival of these scenarios have changed over time. Methods: Patients diagnosed between 2006-2019 with non-metastatic esophageal (including gastro-esophageal junction tumors) or gastric cancer were selected from the Netherlands Cancer Registry. Best-case, typical, and worst-case scenarios were calculated from the 20 th (best-case scenario), 40 th (upper-typical), 50 th (median), 60 th (lower-typical) and 80 th (worst-case scenario) percentiles of the survival curves. Linear trend analysis was used to investigate the change in survival time for each scenario across diagnosis years. Results: We identified 23350 patients with non-metastatic esophageal cancer and 10150 patients with non-metastatic gastric cancer. Linear trend analyses across diagnosis years showed that for esophageal cancer patients, survival of all scenarios significantly increased over time: the best-case scenario increased from 55 to 112 months (p =.003); the upper typical increased from 18 to 33 months (p 〈 .001); the median increased from 13 to 23 months (p 〈 .001); the lower typical increased from 8 to 15 months (p 〈 .001) and the worst-case scenario increased from 4 to 7 months (p 〈 .001). For patients with gastric cancer, all scenarios also improved significantly: the best-case scenario increased from 73 to 99 months (p =.045); the upper-typical increased from 22 to 33 months (p 〈 .001); the median increased from 14 to 18 months (p 〈 .001); the lower-typical increased from 14 to 18 months (p 〈 .001) and the worst-case scenario increased slightly from 2.9 months to 3.0 (p =.017). Conclusions: All patients with non-metastatic esophageal and gastric cancer have improved their survival over time.The largest survival advantage was among the best-case and upper-typical scenarios. Therefore, treatment advances over the last years have improved survival for all patients with non-metastatic esophagogastric cancer.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2022.40.4_suppl.259
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2022
    detail.hit.zdb_id: 2005181-5
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  • 7
    Online Resource
    Online Resource
    Morpheme frequency effects in Dutch complex word reading: A developmental perspective
    Cambridge University Press (CUP) ; 2011
    In:  Applied Psycholinguistics Vol. 32, No. 3 ( 2011-07), p. 483-498
    Details
    In: Applied Psycholinguistics, Cambridge University Press (CUP), Vol. 32, No. 3 ( 2011-07), p. 483-498
    Abstract: This study examined to what extent advanced and beginning readers, including dyslexic readers of Dutch, make use of morphological access units in the reading of polymorphemic words. Therefore, experiments were carried out in which the role of singular root form frequency in reading plural word forms was investigated in a lexical decision task with both adults and children. Twenty-three adult readers, 37 8-year-old children from Grade 3, 43 11-year-old children from Grade 6, and 33 11-year-old dyslexic readers were presented with a lexical decision task in which we contrasted plural word forms with a high versus low frequency of the singular root form. For the adults, it was found that the accuracy and speed of lexical decision is determined by the surface frequency of the plural word form. The frequency of the constituent root form played a role as well, but in the low-frequency plural words only. Furthermore, a strong developmental effect regarding the accuracy and speed of reading plural word forms was found. An effect of plural word form frequency on word identification was evidenced in all groups. The singular root form frequency also had an impact of the reading of the plural word forms. In the normal reading and dyslexic children, plurals with a high-frequency singular root form were read more accurately and faster than plurals with a low singular root frequency. It can be concluded that constituent morphemes have an impact on the reading of polymorphemic words. The results can be explained in the light of a word experience model leaving room for morphological constituency to play a role in the lexical access of complex words as a function of reading skill and experience and word and morpheme frequency.
    Type of Medium: Online Resource
    ISSN: 0142-7164 , 1469-1817
    URL: Article
    DOI: 10.1017/S0142716411000178
    RVK:
    EQ 1285
    RVK:
    EQ 1000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2011
    detail.hit.zdb_id: 1499968-7
    SSG: 5,2
    SSG: 7,11
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  • 8
    Online Resource
    Online Resource
    NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma
    American Society for Microbiology ; 2016
    In:  Journal of Virology Vol. 90, No. 14 ( 2016-07-15), p. 6475-6488
    Details
    In: Journal of Virology, American Society for Microbiology, Vol. 90, No. 14 ( 2016-07-15), p. 6475-6488
    Abstract: Epstein-Barr virus (EBV) expresses few viral proteins in nasopharyngeal carcinoma (NPC) but high levels of BamHI-A rightward transcripts (BARTs), which include long noncoding RNAs (lncRNAs) and BART microRNAs (miRNAs). It is hypothesized that the mechanism for regulation of BARTs may relate to EBV pathogenesis in NPC. We showed that nuclear factor-κB (NF-κB) activates the BART promoters and modulates the expression of BARTs in EBV-infected NPC cells but that introduction of mutations into the putative NF-κB binding sites abolished activation of BART promoters by NF-κB. Binding of p50 subunits to NF-κB sites in the BART promoters was confirmed in electrophoretic mobility shift assays (EMSA) and further demonstrated in vivo using chromatin immunoprecipitation (ChIP) analysis. Expression of BART miRNAs and lncRNAs correlated with NF-κB activity in EBV-infected epithelial cells, while treatment of EBV-harboring NPC C666-1 cells with aspirin (acetylsalicylic acid [ASA]) and the IκB kinase inhibitor PS-1145 inhibited NF-κB activity, resulting in downregulation of BART expression. Expression of EBV LMP1 activates BART promoters, whereas an LMP1 mutant which cannot induce NF-κB activation does not activate BART promoters, further supporting the idea that expression of BARTs is regulated by NF-κB signaling. Expression of LMP1 is tightly regulated in NPC cells, and this study confirmed that miR-BART5-5p downregulates LMP1 expression, suggesting a feedback loop between BART miRNA and LMP1-mediated NF-κB activation in the NPC setting. These findings provide new insights into the mechanism underlying the deregulation of BARTs in NPC and identify a regulatory loop through which BARTs support EBV latency in NPC. IMPORTANCE Nasopharyngeal carcinoma (NPC) cells are ubiquitously infected with Epstein-Barr virus (EBV). Notably, EBV expresses very few viral proteins in NPC cells, presumably to avoid triggering an immune response, but high levels of EBV BART miRNAs and lncRNAs which exhibit complex functions associated with EBV pathogenesis. The mechanism for regulation of BARTs is critical for understanding NPC oncogenesis. This study provides multiple lines of evidence to show that expression of BARTs is subject to regulation by NF-κB signaling. EBV LMP1 is a potent activator of NF-κB signaling, and we demonstrate that LMP1 can upregulate expression of BARTs through NF-κB signaling and that BART miRNAs are also able to downregulate LMP1 expression. It appears that aberrant NF-κB signaling and expression of BARTs form an autoregulatory loop for maintaining EBV latency in NPC cells. Further exploration of how targeting NF-κB signaling interrupts EBV latency in NPC cells may reveal new options for NPC treatment.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    URL: Article
    DOI: 10.1128/JVI.00613-16
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2016
    detail.hit.zdb_id: 1495529-5
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  • 9
    Online Resource
    Online Resource
    Traceability of Loss Measurements of Extra High Voltage Three-Phase Shunt Reactors
    Institute of Electrical and Electronics Engineers (IEEE) ; 2015
    In:  IEEE Transactions on Instrumentation and Measurement Vol. 64, No. 6 ( 2015-6), p. 1344-1349
    Details
    In: IEEE Transactions on Instrumentation and Measurement, Institute of Electrical and Electronics Engineers (IEEE), Vol. 64, No. 6 ( 2015-6), p. 1344-1349
    Type of Medium: Online Resource
    ISSN: 0018-9456 , 1557-9662
    URL: Article
    DOI: 10.1109/TIM.2015.2398956
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2015
    detail.hit.zdb_id: 160442-9
    detail.hit.zdb_id: 2027532-8
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  • 10
    Online Resource
    Online Resource
    Hospital of Diagnosis Influences the Probability of Receiving Curative Treatment for Esophageal Cancer
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Annals of Surgery Vol. 267, No. 2 ( 2018-02), p. 303-310
    Details
    In: Annals of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 267, No. 2 ( 2018-02), p. 303-310
    Type of Medium: Online Resource
    ISSN: 0003-4932
    URL: Article
    DOI: 10.1097/SLA.0000000000002063
    RVK:
    XA 23900
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2002200-1
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