In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 9_Supplement ( 2015-05-01), p. P6-08-45-P6-08-45
Abstract:
Background Staging of axillary lymph nodes in invasive breast cancer is an important prognostic indicator. Various prediction models have been developed to predict the risk of not having additional axillary metastases in patients with a positive sentinel node, thereby disregarding patients with a positive ultrasound. However, it is important to identify all patients with extensive nodal involvement, defined as 3 or more positive axillary lymph nodes, in whom an axillary lymph node dissection cannot be omitted. Aim This study aims to identify factors predicting extensive nodal involvement in the axilla, with the emphasis on the method of axillary staging; ultrasound guided lymph node biopsy versus sentinel node procedure. Methods All patients diagnosed with invasive breast cancer in the period between January 2006 and December 2011 at the breast center of the Máxima Medical Center were studied. Univariate and multivariate regression analyses were performed. Variables with a p-value of ≤0.10 in univariate analyses were entered in the multivariate model where a p-value of ≤0.05 was considered statistically significant. Results We included 307 cases, representing 306 node positive patients, of whom 178 cases had 1 or 2 positive lymph nodes and 129 cases had 3 or more positive lymph nodes. Multivariate analyses showed that factors as a positive axillary ultrasound (OR=4.513; 95%CI=2.30-8.86), palpability of axillary lymph nodes (OR=2.143; 95%CI=1.04-4.42) and lymphovascular invasion (OR=3.622; 95%CI=1.63-7.81) are significantly associated with extensive nodal involvement in patients with invasive breast cancer. Conclusion This study has identified clinically important factors predicting extensive nodal involvement in patients with a positive lymph node biopsy by either a sentinel lymph node procedure or an ultrasound guided lymph node biopsy. Hence, the role of axillary staging by ultrasound should be redefined since it might play an important role in selecting patients with extensive nodal involvement who, in our opinion, may still benefit from axillary treatment. Citation Format: Nicole C Verheuvel, Ingrid Van den Hoven, Hendrik WA Ooms, Vivianne CG Tjan-Heijnen, Rudi MH Roumen, Adri C Voogd. Predictive characteristics for extensive nodal involvement in patients with axillary lymph node metastases [abstract] . In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P6-08-45.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.SABCS14-P6-08-45
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2015
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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