In:
Science, American Association for the Advancement of Science (AAAS), Vol. 340, No. 6135 ( 2013-05-24)
Abstract:
CD8 + T cell responses focus on a small fraction of pathogen- or vaccine-encoded peptides, and for some pathogens, these restricted recognition hierarchies limit the effectiveness of antipathogen immunity. We found that simian immunodeficiency virus (SIV) protein–expressing rhesus cytomegalovirus (RhCMV) vectors elicit SIV-specific CD8 + T cells that recognize unusual, diverse, and highly promiscuous epitopes, including dominant responses to epitopes restricted by class II major histocompatibility complex (MHC) molecules. Induction of canonical SIV epitope–specific CD8 + T cell responses is suppressed by the RhCMV-encoded Rh189 gene (corresponding to human CMV US11 ), and the promiscuous MHC class I– and class II–restricted CD8 + T cell responses occur only in the absence of the Rh157.5 , Rh157.4 , and Rh157.6 (human CMV UL128 , UL130 , and UL131 ) genes. Thus, CMV vectors can be genetically programmed to achieve distinct patterns of CD8 + T cell epitope recognition.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1237874
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2013
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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