In:
European Journal of Organic Chemistry, Wiley, Vol. 2010, No. 11 ( 2010-04), p. 2148-2156
Abstract:
The stereoselective synthesis of the three major fragments (C1–C9, C10–C17, and C19–C26) of an antimitotic marine macrolide, (–)‐dictyostatin, has been achieved with a desymmetrization strategy and Oppolzer syn and anti aldol protocols as the key reactions. Takai olefination and Sonogashira coupling reactions were successfully utilized to establish the 2 Z ,4 E ‐dienoate portion of the C1–C9 fragment and Stille coupling for the Z ‐diene core of C19–C26.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2010:11
DOI:
10.1002/ejoc.200901448
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1475010-7
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