In:
Experimental and Clinical Endocrinology & Diabetes, Georg Thieme Verlag KG, Vol. 130, No. 11 ( 2022-11), p. 740-750
Abstract:
Background Not much is known about the effects of glycemic variability
(GV) during the pre- and periconception period on pregnancy/perinatal complications. GV could potentially contribute to identification of high-risk
pregnancies in women with type 1 diabetes. Methods An explorative retrospective cohort study was conducted between
January 2014 and May 2019. Glucose data were retrieved from electronic patient charts. Pre-/periconceptional GV and GV during all three trimesters was
expressed as mean glucose, standard deviation (SD), Coefficient of Variation (CV), High Blood Glucose Index (HBGI), Low Blood Glucose Index (LBGI) and
Average Daily Risk Range (ADRR). Maternal and neonatal complications were summarized using a composite total complication score. Binary logistic
regression analyses were conducted to assess associations between the GV measures and a total complication score 〉 3, a maternal complication
score 〉 1 and a neonatal complication score 〉 1. Results Of 63 eligible women, 29 women (38 pregnancies) were included.
Women in the group with a total complication score 〉 3 had a significantly
higher ADRR at conception (OR 1.1, CI 1.0–1.2, p=0.048). No statistically significant correlations between complication score and any other
GV metric besides the ADRR were found. Although not significant, in the group with a complication score 〉 3, odds ratios 〉 1 were found for SD in
trimester 1 (OR 1.6, CI 0.6–4.5, p=0.357) and trimester 2 (OR 1.8, CI 0.5–6.2, p=0.376). Conclusions Presence of a positive association between GV and pregnancy
and perinatal complications depends on which pregnancy period is assessed and the GV metrics that are used.
Type of Medium:
Online Resource
ISSN:
0947-7349
,
1439-3646
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
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