In:
Open Forum Infectious Diseases, Oxford University Press (OUP)
Abstract:
Fungal meningitis can be associated with epidural anesthesia procedures. Fusariosis is a rare infection typically affecting immunocompromised patients and rarely causes meningitis. During 2022-2023, public health officials responded to a large outbreak of Fusarium solani meningitis associated with epidural anesthesia in Durango, Mexico. Methods The public health response and epidemiological and clinical features of patients affected by this outbreak were described. Coordinated actions were addressed to identify the etiological agent, determine its drug susceptibility, develop diagnostic tests, and implement clinical and epidemiological protocols. Retrospective analyses of clinical variables and outcomes were performed to determine association with better patient survival. Results A total of 1,801 persons exposed to epidural anesthesia were identified, of whom 80 developed meningitis. The presence of Fusarium solani species was found in three brain biopsies which showed susceptibility to Voriconazole and Amphotericin B. After F. solani PCR implementation, 57 patients with meningitis were PCR-screened, and 31 (38.8%) had a positive result. Most patients were female (95%) and cesarean section was the most common surgical procedure (76.3%). The case fatality rate was 51.3% (41 patients) and the median hospitalization duration was 39.5 days (IQR: 18-86 days), 71 patients (88.8%) received Voriconazole/Amphotericin B whereas 64 subjects (80%) additionally received steroids. Cox regression analysis showed an increased lethality risk in patients who received antifungal treatment after 5 days (HR: 2.1, 95% CI 1.01-4.48, p & lt;0.05). Conclusion The Fusarium solani meningitis outbreak in Durango was an unprecedented medical challenge. Timely treatment and effective healthcare management were associated with better survival outcomes.
Type of Medium:
Online Resource
ISSN:
2328-8957
DOI:
10.1093/ofid/ofad690
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2024
detail.hit.zdb_id:
2757767-3
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