In:
JOURNAL OF SURGICAL AND CLINICAL RESEARCH, Journal of Surgical and Clinical Research, Vol. 9, No. 1 ( 2018-10-11), p. 11-23
Abstract:
PURPOSE: This study aimed to evaluate whether the combination of tadalafil treatment and remote ischemic preconditioning may provide protection against ischemia reperfusion injury (I/R) in kidneys of rats. METHODS: Twenty-four male Wistar rats weighing 280-300g were randomly divided into 3 groups: Group 1 - (control), only right nephrectomy was performed. No treatment with tadalafil. Group II - Left renal ischemia, right nephrectomy, without remote preconditioning, treatment with tadalafil (1.0 mg/kg, oral). Group III - Left renal ischemia, right nephrectomy, with remote preconditioning, treatment with tadalafil. RESULTS: 24 h after, urea and creatinine dosage and histopathology of the ischemic kidneys were performed. In the left kidney of control group rats, a higher degree of cellular necrosis was observed when compared to the tadalafil group, with and without remote preconditioning. On the preconditioning + tadalafil group rats, there was a significant reduction in histological parameters when compared to the Ischemia + tadalafil group rats (p 〈 0.05). In group III, comparing to other groups, a significant improvement of the left kidney function was observed, through the lower values of the urea and creatinine dosages. CONCLUSION: This study demonstrated protective effects of remote preconditioning + tadalafil in an experimental model of renal I/R in the rat. The results demonstrated that a single dose of tadalafil prior to renal I/R attenuated the histopathological lesions, especially cellular necrosis, and renal function tests.
Type of Medium:
Online Resource
ISSN:
2179-7889
DOI:
10.20398/jscr.v9i1.15731
Language:
Unknown
Publisher:
Journal of Surgical and Clinical Research
Publication Date:
2018
detail.hit.zdb_id:
2855063-8
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