In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-10-28)
Abstract:
Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elaborated, except in silico as coexpressed genes within QTLs. Here we demonstrate the requirement of multiple intra-QTL genes for the full impact of QTL qDTY 12.1 on rice yield under drought. Multiple evidences are presented for the need of the transcription factor ‘no apical meristem’ ( OsNAM 12.1 ) and its co-localized target genes of separate GO categories for qDTY 12.1 function, raising a regulon-like model of genetic architecture. The molecular underpinnings of qDTY 12.1 support its effectiveness in further improving a drought tolerant genotype and for its validity in multiple genotypes/ecosystems/environments. Resolving the combinatorial value of OsNAM 12.1 with individual intra-QTL genes notwithstanding, identification and analyses of qDTY 12.1 has fast-tracked rice improvement towards food security.
Type of Medium:
Online Resource
ISSN:
2045-2322
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2015
detail.hit.zdb_id:
2615211-3
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