In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 2 ( 2009-02), p. 188-194
Abstract:
To address the role of leukocyte cathepsin-S in advanced lesion composition, we generated chimeric LDLr −/− mice deficient in leukocyte CatS by transplantation with CatS −/− ×LDLr −/− or with LDLr −/− bone marrow. CatS deficiency resulted in considerably altered plaque morphology, with smaller necrotic cores, reduced apoptosis, and decreased SMC content and collagen deposition.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/ATVBAHA.108.181578
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2009
detail.hit.zdb_id:
1494427-3
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