In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-13), p. e0267257-
Abstract:
Silibinin (SB) is shown to have an anticancer properties. However, its clinical therapeutic effects have been restricted due to its low water solubility and poor absorption after oral administration. The aim of this study was to develop SB-loaded PCL/Pluronic F68 nanoparticles for pulmonary delivery in the treatment of lung cancer. A modified solvent displacement process was used to make nanoparticles, which were then lyophilized to make inhalation powder, Nanoparticles were characterized with DSC, FTIR,SEM and In vitro release study. Further, a validated HPLC method was developed to investigate the Biodistribution study, pharmacokinetic parameters. Poly Caprolactone PCL / Pluronic F68 NPs showed the sustained release effect up to 48 h with an emitted (Mass median Aerodynamic diameter)MMAD and (Geometric size distribution)GSD were found to be 4.235 ±0.124 and 1.958±1.23 respectively. More specifically, the SB Loaded PCL/Pluronic F 68 NPs demonstrated long circulation and successful lung tumor-targeting potential due to their cancer-targeting capabilities. SB Loaded PCL/Pluronic F68 NPs significantly inhibited tumour growth in lung cancer-induced rats after inhalable administration. In a pharmacokinetics study, PCL/ Pluronic F68 NPs substantially improved SB bioavailability, with a more than 4-fold rise in AUC when compared to IV administration. These findings indicate that SB-loaded PCL/PluronicF68 nanoparticles may be a successful lung cancer therapy delivery system.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0267257
DOI:
10.1371/journal.pone.0267257.g001
DOI:
10.1371/journal.pone.0267257.g002
DOI:
10.1371/journal.pone.0267257.g003
DOI:
10.1371/journal.pone.0267257.g004
DOI:
10.1371/journal.pone.0267257.g005
DOI:
10.1371/journal.pone.0267257.g006
DOI:
10.1371/journal.pone.0267257.g007
DOI:
10.1371/journal.pone.0267257.g008
DOI:
10.1371/journal.pone.0267257.g009
DOI:
10.1371/journal.pone.0267257.g010
DOI:
10.1371/journal.pone.0267257.g011
DOI:
10.1371/journal.pone.0267257.g012
DOI:
10.1371/journal.pone.0267257.g013
DOI:
10.1371/journal.pone.0267257.g014
DOI:
10.1371/journal.pone.0267257.g015
DOI:
10.1371/journal.pone.0267257.t001
DOI:
10.1371/journal.pone.0267257.t002
DOI:
10.1371/journal.pone.0267257.t003
DOI:
10.1371/journal.pone.0267257.t004
DOI:
10.1371/journal.pone.0267257.t005
DOI:
10.1371/journal.pone.0267257.s001
DOI:
10.1371/journal.pone.0267257.s002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Permalink