In:
Journal of Ural Medical Academic Science, Bulletin of the Ural Medical Academie Science, Vol. 19, No. 3 ( 2022), p. 184-192
Abstract:
The plasticity of the main homeostatic systems immune and neuroendocrine allows the body to resist the actions of adverse factors, but, nevertheless, the latter can cause pathological changes or lead to a limitation in the function of these systems. The paper presents data demonstrating the long-term effects of the immune cells with different functional phenotypes transplantation performed during early postnatal ontogenesis on the syngeneic recipients endocrine system functional activity, assessed by the neuroactive steroid hormones level in the CNS and in blood serum. The relevance of this study is due to the active development of cellular technologies and their successful use in the treatment of many nosological forms of immunological, oncological and hematological diseases, which has significantly improved the survival rate and quality of patient’s life; however the mechanisms of the transplanted cells effect on the body as a whole remain insufficiently studied, especially in childhood, when the formation of regulatory connections of the main homeostatic systems of the body that maintain dynamic homeostasis is taking place, and it is difficult to predict the long-term effect of therapy, because, even with a directed effect on one of them, influence is exerted on the interconnected functioning of all these systems. Previously, we have shown that immune cells with different functional activities, which is characteristic of individuals with an active or passive type of behavior, after transplantation performed at different stages of ontogenesis, in a cytokine-mediated manner affect the change/formation of a certain neuroimmune status in syngeneic recipients, including the behavioral phenotype. The presented study shows that after a threefold administration of immune cells in the juvenile period, a certain hormonal status is formed in syngeneic recipients by puberty: in all recipients, after cell transplantation, the level of corticosterone in the brain and its separate structures, as well as in the peripheral blood serum, was relatively higher than that in animals raised without adoptive cell transfer; at the same time, there was a pronounced tendency to increase the level of testosterone in the blood serum, and different levels of testosterone were recorded in the hypothalamus, hippocampus, striatum, and frontal cortex. Distinctive features of the central and peripheral levels of corticosterone and testosterone in recipients after multiple transplantation of splenocytes in the late period of maturity are determined by the different functional phenotype of the injected immune cells.
Type of Medium:
Online Resource
ISSN:
2073-9125
,
2500-0918
DOI:
10.22138/2500-0918-2022-19-3-184-192
Language:
Unknown
Publisher:
Bulletin of the Ural Medical Academie Science
Publication Date:
2022
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