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  • 1
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    Online Resource
    Enzyme activities in soil at increasing metal (Cu, Ni, Pb) doses and time-dependence in a model experiment
    University of Szeged ; 2020
    In:  Analecta Technica Szegedinensia Vol. 14, No. 1 ( 2020-06-08), p. 43-49
    Details
    In: Analecta Technica Szegedinensia, University of Szeged, Vol. 14, No. 1 ( 2020-06-08), p. 43-49
    Abstract: Aim of this paper is to examine the effect of spiked copper (Cu), nickel (Ni) and lead (Pb) metal salts on the dehydrogenase (oxydo-reductase) and phosphatase (hydrolase) enzyme activities in a characteristic Hungarian soil, the pseudomycelliar chernozem. Pot-experiment was performed with a soil, originating from a spot of the Hungarian soil-information-monitoring (TIM) system of Bicserd. The added metal salts were used in water soluble forms and incorporated uniformly to the soil. Soils were treated with increasing metal concentrations to give the following metal amounts: 0, 50, 200, and 800 kg.ha-1. Enzyme activities of the soil were analysed at the 0th, 7 th, 14 th, and 28th days after the metal addition. The laboratory model-experiment has been set up in three replicates. Effects of metal salts were largely dependent on the chemical and physical properties of pseudomycelliar chernozem soil, the applied heavy metal-types, the doses of used metals and the elapsed time after the pollution. Considering the different metals, the copper prowed to be the most toxic one on the studied enzyme activities, whereas the lead induced those. By comparison with copper the nickel affected a smaller decrease in the soil microbial activity. The dehydrogenase, oxydo-reductase enzyme was found to be more sensitive parameter in comparison with the phosphatase, hydrolase enzyme among the studied condition. Studied enzymes and used methods are suggested, as fast and rather reliable tools for estimating the soil-resilience capacities at heavy metal pollution.
    Type of Medium: Online Resource
    ISSN: 2064-7964
    URL: Article
    DOI: 10.14232/analecta.2020.1.43-49
    Language: English
    Publisher: University of Szeged
    Publication Date: 2020
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  • 2
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    The Effect of Passive Movement for Paretic Ankle-Foot and Brain Activity in Post-Stroke Patients
    S. Karger AG ; 2016
    In:  European Neurology Vol. 76, No. 3-4 ( 2016), p. 132-142
    Details
    In: European Neurology, S. Karger AG, Vol. 76, No. 3-4 ( 2016), p. 132-142
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This study aims at investigating the short-term efficacy of the continuous passive motion (CPM) device developed for the therapy of ankle-foot paresis and to investigate by fMRI the blood oxygen level-dependent responses (BOLD) during ankle passive movement (PM). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Sixty-four stroke patients were investigated. Patients were assigned into 2 groups: 49 patients received both 15 min manual and 30 min device therapy (M + D), while the other group (n = 15) received only 15 min manual therapy (M). A third group of stroke patients (n = 12) was investigated by fMRI before and immediately after 30 min CPM device therapy. There was no direct relation between the fMRI group and the other 2 groups. All subjects were assessed using the Modified Ashworth Scale (MAS) and a goniometer. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Mean MAS decreased, the ankle's mean plantar flexion and dorsiflexion passive range of motion (PROM) increased and the equinovalgus improved significantly in the M + D group. In the fMRI group, the PM of the paretic ankle increased BOLD responses; this was observed in the contralateral pre- and postcentral gyrus, superior temporal gyrus, central opercular cortex, and in the ipsilateral postcentral gyrus, frontal operculum cortex and cerebellum. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Manual therapy with CPM device therapy improved the ankle PROM, equinovalgus and severity of spasticity. The ankle PM increased ipsi- and contralateral cortical activation.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000448033
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482237-4
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  • 3
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    Ankle-Foot Continuous Passive Motion Device for Mobilization of Acute Stroke Patients
    Scientific Research Publishing, Inc. ; 2015
    In:  Open Journal of Therapy and Rehabilitation Vol. 03, No. 02 ( 2015), p. 23-34
    Details
    In: Open Journal of Therapy and Rehabilitation, Scientific Research Publishing, Inc., Vol. 03, No. 02 ( 2015), p. 23-34
    Type of Medium: Online Resource
    ISSN: 2332-1822 , 2332-1830
    URL: Article
    DOI: 10.4236/ojtr.2015.32004
    Language: Unknown
    Publisher: Scientific Research Publishing, Inc.
    Publication Date: 2015
    detail.hit.zdb_id: 2781984-X
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  • 4
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    Population‐Level Correction of Systematic Motion Artifacts in fMRI in Patients with Ischemic Stroke
    Wiley ; 2017
    In:  Journal of Neuroimaging Vol. 27, No. 4 ( 2017-07), p. 397-408
    Details
    In: Journal of Neuroimaging, Wiley, Vol. 27, No. 4 ( 2017-07), p. 397-408
    Abstract: The aim of this study was to reveal potential sources of systematic motion artifacts in stroke functional magnetic resonance imaging (fMRI) focusing on those causing stimulus‐correlated motion on the individual‐level and separate the motion effect on the fMRI signal changing from the activation‐induced alteration at population level. METHODS Eleven ischemic stroke patients were examined by fMRI. The fMRI paradigm was based on passive ankle movement on both the healthy and the paretic leg's side. Three individual‐level motion correction strategies were compared and we introduced five measures to characterize each subjects' in‐scanner relative head movement. After analyzing the correlation of motion parameters and the subjects’ physiological scale scores, we selected a parameter to model the motion‐related artifacts in the second‐level analysis. RESULTS At first (individual) level analysis, the noise‐component correction‐based CompCor method provided the highest −log10( p ) value of cluster‐level occurrence probability at 12.4/13.6 for healthy and paretic side stimulus, respectively, with a maximal z ‐value of 15/16.3. Including the motion parameter at second (group) level resulted in lower cluster occurrence values at 10.9/5.55 while retaining the maximal z ‐value. CONCLUSIONS We proposed a postprocessing pipeline for ischemic stroke fMRI data that combine the CompCor correction at first level with the modeling of motion effect at second‐level analysis by a parameter obtained from fMRI data. Our solution is applicable for any fMRI‐based stroke rehabilitation study since it does not require any MRI‐compatible motion capture system and is based on commonly used methods.
    Type of Medium: Online Resource
    ISSN: 1051-2284 , 1552-6569
    URL: Issue
    URL: Article
    DOI: 10.1111/jon.2017.27.issue-4
    DOI: 10.1111/jon.12408
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2035400-9
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  • 5
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    Online Resource
    Anticoagulant therapy in practice
    Akademiai Kiado Zrt. ; 2012
    In:  Orvosi Hetilap Vol. 153, No. 19 ( 2012-05), p. 732-736
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 153, No. 19 ( 2012-05), p. 732-736
    Abstract: Atrial fibrillation is a risk factor for ischemic stroke. To prevent stroke oral anticoagulants can be administered. Old and new types of anticoagulants are available. Nowadays, old type, acenocumarol based anticoagulants are used preferentially in Hungary. Aim: The advantages and the disadvantages of anticoagulants are well known, but anticoagulants are underused in many cases. Method: The authors retrospectively examined how frequent atrial fibrillation was and whether the usage of anticoagulants in practice was in accordance with current guidelines among acute stroke cases admitted to the Department of Neurology, Medical and Health Science Centre of Debrecen University in 2009. Results: Of the 461 acute stroke cases, 96 patients had known and 22 patients had newly discovered atrial fibrillation. Half of the patients did not receive proper anticoagulation. Only 8.4% of them had their INR levels within the therapeutic range. Conclusions: The findings are similar to those reported in other studies. Many factors may contribute to the high proportion of improper use of anticoagulants, and further investigations are needed to determine these factors. In any case, elimination of these factors leading to a failure of anticoagulation may decrease the incidence of stroke. Orv. Hetil., 2012, 153, 732–736.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/OH.2012.29357
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2012
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  • 6
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    Table 3: Summarized statistical table of extrinsic (endogenous) connection strength analysis of the winning model performed by Monte-Carlo-based exact permutation tests following False Discovery Rate (FDR) correction.
    PeerJ ; 2020
    In:  PeerJ Vol. 8 ( 2020-05-26), p. e8942-
    Details
    In: PeerJ, PeerJ, Vol. 8 ( 2020-05-26), p. e8942-
    Abstract: A better understanding of the neural changes associated with paresis in stroke patients could have important implications for therapeutic approaches. Dynamic Causal Modeling (DCM) for functional magnetic resonance imaging (fMRI) is commonly used for analyzing effective connectivity patterns of brain networks due to its significant property of modeling neural states behind fMRI signals. We applied this technique to analyze the differences between motor networks (MNW) activated by continuous passive movement (CPM) of paretic and non-paretic ankles in subacute stroke patients. This study aimed to identify CPM induced connectivity characteristics of the primary sensory area (S1) and the differences in extrinsic directed connections of the MNW and to explain the hemodynamic differences of brain regions of MNW. Methods For the network analysis, we used ten stroke patients’ task fMRI data collected under CPMs of both ankles. Regions for the MNW, the primary motor cortex (M1), the premotor cortex (PM), the supplementary motor area (SMA) and the S1 were defined in a data-driven way, by independent component analysis. For the network analysis of both CPMs, we compared twelve models organized into two model-families, depending on the S1 connections and input stimulus modeling. Using DCM, we evaluated the extrinsic connectivity strengths and hemodynamic parameters of both stimulations of all patients. Results After a statistical comparison of the extrinsic connections and their modulations of the “best model”, we concluded that three contralateral self-inhibitions (cM1, cS1 and cSMA), one contralateral inter-regional connection (cSMA→cM1), and one interhemispheric connection (cM1→iM1) were significantly different. Our research shows that hemodynamic parameters can be estimated with the Balloon model using DCM but the parameters do not change with stroke. Conclusions Our results confirm that the DCM-based connectivity analyses combined with Bayesian model selection may be a useful technique for quantifying the alteration or differences in the characteristics of the motor network in subacute stage stroke patients and in determining the degree of MNW changes.
    Type of Medium: Online Resource
    ISSN: 2167-8359
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.7717/peerj.8942
    DOI: 10.7717/peerj.8942/fig-1
    DOI: 10.7717/peerj.8942/fig-2
    DOI: 10.7717/peerj.8942/fig-3
    DOI: 10.7717/peerj.8942/fig-4
    DOI: 10.7717/peerj.8942/fig-5
    DOI: 10.7717/peerj.8942/table-1
    DOI: 10.7717/peerj.8942/table-2
    DOI: 10.7717/peerj.8942/table-3
    Language: English
    Publisher: PeerJ
    Publication Date: 2020
    detail.hit.zdb_id: 2703241-3
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