In:
Mini-Reviews in Organic Chemistry, Bentham Science Publishers Ltd., Vol. 21, No. 4 ( 2024-06), p. 477-493
Abstract:
Natural products are secondary metabolites obtained from plants, animals,
and microorganisms with diverse chemical structures resulting in diverse biological functions and drug-like properties. Objective: This review article summarizes in detail the occurrence, detection, isolation, various
pharmacological properties, metabolism, and toxicity of a natural compound i.e., 5-Allyl-1-methoxy- 2,3-methylenedioxybenzene commonly known as Myristicin. Methods: A relevant literature search was made using the keywords essential oil, mace, myristicin,
nutmeg, and pharmacological activities from different databases such as PubMed, Sci Finder, Science Direct, and Google Scholar. The literature search results presented articles from 1963 to 2022. Thereafter,
the articles were carefully screened and selected for review. Results: Myristicin, an alkoxy-substituted allylbenzene is present in major to minor amounts in the
essential oils obtained from different plant parts and exhibits various pharmacological properties such as antimicrobial, antioxidant, antiproliferative, anti-inflammatory, insecticidal, and hepatoprotective.
It forms 10 metabolites by reduction, demethylation, hydroxylation, ring formation, ring-opening, and conjugate formation. In the liver, myristicin has been metabolized by Cytochrome P450 complex
enzymes to generate active metabolite (1ˈ hyroxymyristicin) responsible for cytotoxic, genotoxic and apoptotic effects (150 μM). But, myristicin at 600 μM does not produce enough 1ʼ-hydroxymyristicin
to give the final toxicant. Conclusion: Myristicin poses no major risk to human health through the consumption of herbs and
spices due to its presence in low amounts. It has great potential to be used in the traditional system of medicine. We hope that this review will provide complete knowledge about myristicin on a single
platform.
Type of Medium:
Online Resource
ISSN:
1570-193X
DOI:
10.2174/1570193X20666230314105024
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2024
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