In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 76, No. 2 ( 1974-06), p. 392-402
Abstract:
Testicular monoamine oxidase activity (MAO) was measured in rats subjected to adrenalectomy, hypophysectomy, or hypophysectomy and treatment with either HCG, FSH, LH, prolactin, or a combination of FSH, LH, and prolactin. Total testicular MAO activity was reduced by hypophysectomy, but unchanged by adrenalectomy. The specific activity of MAO, expressed as units of activity per mg of tissue, increased after hypophysectomy, suggesting that this enzyme is located in a non-germinal-type cell in the testis. In the mature animals total MAO activity decreased during the first 4 weeks and then increased to near normal levels 2 weeks later. Specific activity of MAO increased the first 7 weeks after surgery in immature animals and for 6 weeks for mature animals. In immature animals the specific activity of MAO had regressed to the control level by 15 weeks after surgery. FSH was more effective in increasing total MAO activity, but LH in high concentrations may be capable of increasing it. Additions of 2 or 5 IU of FSH to seminiferous tubules in organ culture also increased MAO activity. Treatment of hypophysectomized animals with HCG or a combination of FSH, LH, and prolactin increased testicular weights and androgen synthesis, but depressed specific MAO activity. Thus, androgens do not appear to increase total MAO activity, but could depress it especially at high concentrations. Injections of pargyline, a MAO inhibitor, significantly increased endogenous serotonin concentrations in rat testes.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0760392
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1974
detail.hit.zdb_id:
1485160-X
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