In:
Bioscience, Biotechnology, and Biochemistry, Informa UK Limited, ( 2022-05-02)
Abstract:
A synthetic approach to the CDE-tricyclic structure of nakiterpiosin, a marine-derived antimitotic C-nor-D-homosteroid, is reported. The trans-disubstituted indanone was synthesized from a commercially available carboxylic acid in 9 steps, and the ring closing metathesis of the indanone constructed the trans-fused 5/6-membered ring system. The present approach enables the concise synthesis of the functionalized CDE-tricyclic structure, which will serve as a synthetic intermediate toward nakiterpiosin.
Type of Medium:
Online Resource
ISSN:
1347-6947
Language:
English
Publisher:
Informa UK Limited
Publication Date:
2022
detail.hit.zdb_id:
2110940-0
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