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  • 1
    Online Resource
    Online Resource
    Learning deep architectures for the interpretation of first-trimester fetal echocardiography (LIFE) - a study protocol for developing an automated intelligent decision support system for early fetal echocardiography
    Springer Science and Business Media LLC ; 2023
    In:  BMC Pregnancy and Childbirth Vol. 23, No. 1 ( 2023-01-11)
    Details
    In: BMC Pregnancy and Childbirth, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-01-11)
    Abstract: Congenital Heart Disease represents the most frequent fetal malformation. The lack of prenatal identification of congenital heart defects can have adverse consequences for the neonate, while a correct prenatal diagnosis of specific cardiac anomalies improves neonatal care neurologic and surgery outcomes. Sonographers perform prenatal diagnosis manually during the first or second-trimester scan, but the reported detection rates are low. This project’s primary objective is to develop an Intelligent Decision Support System that uses two-dimensional video files of cardiac sweeps obtained during the standard first-trimester fetal echocardiography (FE) to signal the presence/absence of previously learned key features. Methods The cross-sectional study will be divided into a training part of the machine learning approaches and the testing phase on previously unseen frames and eventually on actual video scans. Pregnant women in their 12–13 + 6 weeks of gestation admitted for routine first-trimester anomaly scan will be consecutively included in a two-year study, depending on the availability of the experienced sonographers in early fetal cardiac imaging involved in this research. The Data Science / IT department (DSIT) will process the key planes identified by the sonographers in the two- dimensional heart cine loop sweeps : four-chamber view, left and right ventricular outflow tracts, three vessels, and trachea view. The frames will be grouped into the classes representing the plane views, and then different state-of-the- art deep-learning (DL) pre-trained algorithms will be tested on the data set. The sonographers will validate all the intermediary findings at the frame level and the meaningfulness of the video labeling. Discussion FE is feasible and efficient during the first trimester. Still, the continuous training process is impaired by the lack of specialists or their limited availability. Therefore, in our study design, the sonographer benefits from a second opinion provided by the developed software, which may be very helpful, especially if a more experienced colleague is unavailable. In addition, the software may be implemented on the ultrasound device so that the process could take place during the live examination. Trial registration The study is registered under the name „Learning deep architectures for the Interpretation of Fetal Echocardiography (LIFE)”, project number 408PED/2020, project code PN-III-P2–2.1-PED-2019. Trial registration: ClinicalTrials.gov , unique identifying number NCT05090306, date of registration 30.10.2020.
    Type of Medium: Online Resource
    ISSN: 1471-2393
    URL: Article
    DOI: 10.1186/s12884-022-05204-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2059869-5
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  • 2
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    Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus
    Revista de Chimie SRL ; 2018
    In:  Revista de Chimie Vol. 69, No. 6 ( 2018-7-15), p. 1537-1540
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 69, No. 6 ( 2018-7-15), p. 1537-1540
    Abstract: Paracetamol (N-acetyl- para-aminophenol) also known as acetaminophen is a chemical compound used in medical practice for analgesic and antipyretic effects. The mechanism of action is related to the cyclooxygenase (COX) activity, which is not full inhibit as for nonsteroidal anti-inflammatory. Paracetamol selectively inhibits COX activities in the brain, indirectly by reducing COX, which must be oxidized in order to function. In addition to analgesic and antipyretic effects, modulating the prostaglandin synthesis by selective inhibition of COX, a vascular modulator effect was described recently on the closure of the patent ductus arteriosus (PDA). This effect has been described in premature newborns, perhaps by decreasing the prostaglandin production. We present the case of a neonate, 39 weeks gestational age, normal birth weight who presented in the 10 th day of life with a cardiac murmur. Echocardiography evidenced a hemodynamically significant PDA, left ventricular enlargement, severe mitral regurgitation, patent foramen ovale and pulmonary hypertension. Although she was a 10-day- old full-term neonate paracetamol administration was attempted. Paracetamol was administered orally in the therapeutic dose of 15 mg/kg/dose, three times a day for three days. The effect was significant by reducing the diameter of the arterial duct (~50% of initial diameter), reducing the size of the left cardiac chambers, reducing the degree of mitral regurgitation from severe to mild, and disappearance of pulmonary hypertension. In conclusion, paracetamol use can change prognosis through the vaso-modulator on the PDA, at the age of 10 days, on a full-term neonate with a normal birth weight. This effect may also be present in full-term newborns and not only in preterm. Even if the PDA was not closed after three days, the hemodynamic impact disappeared and the child could avoid surgical ligation.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.18.6.6363
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2018
    detail.hit.zdb_id: 2488208-2
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  • 3
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    Online Resource
    Prenatal diagnosis of a pure 15q distal trisomy derived from a maternal pericentric inversion: A case report
    Spandidos Publications ; 2021
    In:  Experimental and Therapeutic Medicine Vol. 21, No. 4 ( 2021-01-29)
    Details
    In: Experimental and Therapeutic Medicine, Spandidos Publications, Vol. 21, No. 4 ( 2021-01-29)
    Type of Medium: Online Resource
    ISSN: 1792-0981 , 1792-1015
    URL: Journal
    URL: Article
    DOI: 10.3892/etm
    DOI: 10.3892/etm.2021.9735
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2021
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  • 4
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    Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts
    MDPI AG ; 2023
    In:  Materials Vol. 16, No. 9 ( 2023-04-29), p. 3472-
    Details
    In: Materials, MDPI AG, Vol. 16, No. 9 ( 2023-04-29), p. 3472-
    Abstract: The present work describes, for the first time in the literature, the phytosynthesis of silver nanoparticles using Leonurus cardiaca L. extracts. The influence of the extraction method (classical temperature extraction and microwave extraction), as well as of the extract concentration on the characteristics of the nanoparticles, was studied using analytical methods, such as UV-Vis spectrometry, X-ray diffraction, dynamic light scattering, and transmission electron microscopy. Experimental data suggest that use of lower extract concentration leads to smaller dimensions nanoparticles, the same effect using the extract obtained by microwave-assisted extraction. The smallest recorded crystallite sizes (by X-ray diffraction) were under 3 nm. The antioxidant properties (determined by the DPPH assay) and the antimicrobial potential (determined against Gram-negative and Gram-positive strains) are enhanced by the phytosynthesis process (as demonstrated by the comparison of the nanoparticles’ properties with the parent extracts). The present work could also represent an important step in obtaining nanoparticles with enhanced properties and controlled morphologies, but also offers information on the phytosynthesis of metallic nanoparticles using low extract concentrations.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma16093472
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2487261-1
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  • 5
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    Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts
    MDPI AG ; 2022
    In:  Materials Vol. 15, No. 20 ( 2022-10-20), p. 7327-
    Details
    In: Materials, MDPI AG, Vol. 15, No. 20 ( 2022-10-20), p. 7327-
    Abstract: With their phytoconstituents acting as reducing and capping agents, natural extracts can be considered a viable alternative for the obtaining of metallic nanoparticles. The properties of phytosynthesized nanoparticles are dependent upon size and morphology, which, in turn, can be tailored by adjusting different parameters of the phytosynthesis process (such as the extracts’ composition). In the present study, we aimed to evaluate, for the first time in the literature, the influence of the extraction method and extract concentration on the morphological and biological properties (antioxidant and antibacterial activity) of silver nanoparticles phytosynthesized using Echinacea pupurea L. extracts. The obtained results revealed that the use of the low-concentration Echinacea hydro-alcoholic extract obtained via classical temperature extraction led to the development of nanoparticles with the smallest dimensions (less than 10 nm), compared with the use of extracts obtained with higher concentrations and the extract obtained via the microwave method. The developed nanomaterials exhibited enhanced antioxidant effects (determined via the DPPH assay) and antimicrobial properties (against Escherichia coli and Candida albicans), compared with the parent extracts.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma15207327
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2487261-1
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  • 6
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    Online Resource
    Metallic and Metal Oxides Nanoparticles for Sensing Food Pathogens—An Overview of Recent Findings and Future Prospects
    MDPI AG ; 2022
    In:  Materials Vol. 15, No. 15 ( 2022-08-04), p. 5374-
    Details
    In: Materials, MDPI AG, Vol. 15, No. 15 ( 2022-08-04), p. 5374-
    Abstract: Nowadays, special importance is given to quality control and food safety. Food quality currently creates significant problems for the industry and implicitly for consumers and society. The effects materialize in economic losses, alterations of the quality and organoleptic properties of the commercial products, and, last but not least, they constitute risk factors for the consumer’s health. In this context, the development of analytical systems for the rapid determination of the sanitary quality of food products by detecting possible pathogenic microorganisms (such as Escherichia coli or Salmonella due to the important digestive disorders that they can cause in many consumers) is of major importance. Using efficient and environmentally friendly detection systems for identification of various pathogens that modify food matrices and turn them into food waste faster will also improve agri-food quality throughout the food chain. This paper reviews the use of metal nanoparticles used to obtain bio nanosensors for the purpose mentioned above. Metallic nanoparticles (Au, Ag, etc.) and their oxides can be synthesized by several methods, such as chemical, physical, physico-chemical, and biological, each bringing advantages and disadvantages in their use for developing nanosensors. In the “green chemistry” approach, a particular importance is given to the metal nanoparticles obtained by phytosynthesis. This method can lead to the development of good quality nanoparticles, at the same time being able to use secondary metabolites from vegetal wastes, as such providing a circular economy character. Considering these aspects, the use of phytosynthesized nanoparticles in other biosensing applications is also presented as a glimpse of their potential, which should be further explored.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma15155374
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2487261-1
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  • 7
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    Online Resource
    Technology for biohumus production, an alternative to conventional fertilizers for bio agriculture
    EDP Sciences ; 2021
    In:  E3S Web of Conferences Vol. 286 ( 2021), p. 03014-
    Details
    In: E3S Web of Conferences, EDP Sciences, Vol. 286 ( 2021), p. 03014-
    Abstract: Composting is the process of decomposition and transformation of solid organic substances by microorganisms (mainly bacteria and fungi) into a stable material, which can be used (depending on characteristics) in agriculture, instead of chemical fertilizers or land improvement works (soil improvement. The composting process consists of two stages: mechanical treatment and decomposition (fermentation). In the case of mechanical treatment, the waste is crushed, homogenized and prepared for biological treatment, fermentation. The fermentation stage consists in three main stages, namely the mesophilic fermentation stage, the thermophilic fermentation stage and the maturation stage of the compost.
    Type of Medium: Online Resource
    ISSN: 2267-1242
    URL: Article
    DOI: 10.1051/e3sconf/202128603014
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 2755680-3
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  • 8
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    Online Resource
    The Random Vibrations of the Active Body of the Cultivators
    MDPI AG ; 2023
    In:  Agriculture Vol. 13, No. 8 ( 2023-08-04), p. 1565-
    Details
    In: Agriculture, MDPI AG, Vol. 13, No. 8 ( 2023-08-04), p. 1565-
    Abstract: The article continues the exposition of the results obtained in researching an agricultural machine for processing soil, designed for research with applications including exploitation. The MCLS (complex machine for soil tillage) was designed to research the working processes of the instruments intended for soil processing. The MCLS cultivator is a modulated machine (it can work for three working widths: 1, 2, and 4 m, with tractors of different powers) that is designed to use a wide range of working bodies. The experimental data obtained with the structure with a working width of 1 m and the results of their processing within the framework of the theory of random vibrations are presented in this article. The experimental results are analysed as random vibrations of the supports of the active working bodies. As a result, the main characteristics of random vibrations are exposed: the distribution function, the average value, the autocorrelation, and the frequency spectrum. These general results regarding random vibrations are used for several critical applications in the design, execution, and exploitation of some subassemblies and assemblies of agricultural machines of this type. The main applications include estimating the probability of the occurrence of dangerous load peaks, counting and selecting the load peaks that produce fatigue accumulation in the material of the supports of the working bodies, identifying some design deficiencies or defects in the work regime, and estimating the effects of vibrations on the quality of soil processing. All of the outcomes are composed of applications in MCLS research and exploitation. The applications pursue well-known objectives of modelling the working processes of agricultural machines: safety at work, increasing the quality of work, optimising energy consumption, and increasing productivity, all in a broad context to obtain a compromise situation. The material and the method are based on experimental data acquisition, processing, and interpretation.
    Type of Medium: Online Resource
    ISSN: 2077-0472
    URL: Article
    DOI: 10.3390/agriculture13081565
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2651678-0
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  • 9
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    Online Resource
    Platinum Group Elements in Road Dust and Vegetation from Some European and National Roads with Intensive Car Traffic in Romania
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 70, No. 1 ( 2019-2-15), p. 286-292
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 1 ( 2019-2-15), p. 286-292
    Abstract: The paper presents a monitoring study of the platinum group metals concentrations in 17 samples of road dust and vegetation from areas with heavy car traffic on several European and national roads in eastern Romania. The Ir, Pd, Pt, Rh, Ru concentrations were determined by the ICP-MS technique, the reported values being below the method�s limit of determination for Ir, Pt and Ru both in soil and vegetation. As regards the Pd content, it showed a maximum of 794 mg / kg dry matter in Focsani area (DN2), an area where, according to national data published by National Road Infrastructure Management Company, the traffic average is 16,000 vehicles / 24 h. Approximately 50% of the collected vegetation samples showed a Pd transfer factor from the solid part to the vegetation higher than 0.5, thus indicating the existence of Pd toxic compounds bioavailable for vegetation. The highest concentrations of Rh in soil were recorded on a high traffic section on the E85, in Ramnicu Sarat area, where the traffic interval ranges from 8,001 to 16,000 vehicles / 24 h.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.19.1.6901
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 10
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    Correction: Learning deep architectures for the interpretation of first‑trimester fetal echocardiography (LIFE) ‑ a study protocol for developing an automated intelligent decision support system for early fetal echocardiography
    Springer Science and Business Media LLC ; 2023
    In:  BMC Pregnancy and Childbirth Vol. 23, No. 1 ( 2023-07-05)
    Details
    In: BMC Pregnancy and Childbirth, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-07-05)
    Type of Medium: Online Resource
    ISSN: 1471-2393
    URL: Article
    DOI: 10.1186/s12884-023-05825-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2059869-5
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