In:
Intervirology, S. Karger AG, Vol. 50, No. 1 ( 2007), p. 32-39
Abstract:
〈 i 〉 Objective: 〈 /i 〉 The aim of this study was to determine the association between pretreatment intrahepatic mRNA levels of interferon receptor and interferon-stimulated genes and response to interferon therapy for genotype 1b chronic hepatitis C. 〈 i 〉 Methods: 〈 /i 〉 Forty-four patients with genotype 1b chronic hepatitis C who underwent liver biopsy and then received interferon therapy participated in this study. Pretreatment intrahepatic mRNA levels of interferon receptor genes ( 〈 i 〉 IFNAR1 〈 /i 〉 , 〈 i 〉 IFNAR2b 〈 /i 〉 , and 〈 i 〉 IFNAR2c 〈 /i 〉 ) and interferon-stimulated genes ( 〈 i 〉 OAS1 〈 /i 〉 and 〈 i 〉 PKR 〈 /i 〉 ) were quantified by competitive polymerase chain reaction. 〈 i 〉 Results: 〈 /i 〉 In the genes examined, only IFNAR1 mRNA level was significantly higher in patients with sustained virological and biochemical response to interferon therapy versus those with nonsustained response (p 〈 0.01). Moreover, mRNA expression ratios of IFNAR1 to IFNAR2 were also significantly higher in patients with sustained virological and biochemical response to IFN therapy (p 〈 0.01 and p 〈 0.05, respectively). On the other hand, mRNA levels of IFNAR2b, IFNAR2c, and PKR were significantly higher in patients with histologically active or advanced liver rather than patients with mild or less advanced liver. 〈 i 〉 Conclusions: 〈 /i 〉 High intrahepatic mRNA levels of IFNAR1 and mRNA ratio of IFNAR1 to IFNAR2 before treatment may be associated with a favorable response to interferon therapy.
Type of Medium:
Online Resource
ISSN:
0300-5526
,
1423-0100
Language:
English
Publisher:
S. Karger AG
Publication Date:
2007
detail.hit.zdb_id:
1482863-7
SSG:
12
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