In:
Cellular Oncology, Springer Science and Business Media LLC, Vol. 44, No. 4 ( 2021-08), p. 793-803
Abstract:
Expansion of CD8 + cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy. Methods To understand the CD8 + T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8 + proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples. Results The density and the percentage of proliferating (Ki67 + ) CD8 + T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8 + cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage ( p ≤ 0.0041 each), prolonged overall survival ( p ≤ 0.0028 each) and an inflamed immune phenotype ( p = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p ≤ 0.003), shorter overall survival ( p ≤ 0.0330 each) and an immune inflamed phenotype ( p = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67 + )CD8 + Tcells was not linked to clinicopathological data. Conclusion Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67 + )CD8 + Tcells and an inverse impact in colorectal and renal cell cancer.
Type of Medium:
Online Resource
ISSN:
2211-3428
,
2211-3436
DOI:
10.1007/s13402-021-00601-4
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2595105-1
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