In:
Natural Product Communications, SAGE Publications, Vol. 14, No. 5 ( 2019-05), p. 1934578X1985069-
Abstract:
Five quassinoids and 2 alkaloids were isolated from the roots of Eurycoma longifolia. The structures of 3 new quassinoids, eurycomalide F, G, and H (1-3), were elucidated using a variety of spectroscopic methods. The known compounds were identified as eurycomalide A (4), laurycolactone B (5), 5-methoxycanthin-6-one (6), and canthin-6-one (7). Among the isolated compounds, canthin-6-one (7) exhibited the strongest inhibitory effect on nitric oxide production (IC 50 = 16.9 μM). 5-Methoxycanthin-6-one (6) and eurycomalide F (1) exhibited weak inhibition with IC 50 values of 23.4 and 32.7 μM, respectively.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X19850695
Language:
English
Publisher:
SAGE Publications
Publication Date:
2019
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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