In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. 1534-1534
Abstract:
1534 Background: The epidemiological, multicenter prospective study (NCT01185314; PIONEER) assessed EGFR mutation (M) rates in pts from Asia with newly diagnosed advanced lung adenocarcinoma (ADC). Influence of demographic and clinical factors on EGFR M rates was investigated. Methods: Pts were aged ≥20 years, with treatment naïve stage IIIB/IV lung ADC. Tumor sample (biopsy, surgical specimen, cytology) EGFR M status (primary endpoint; positive [M+], negative [M-] , undetermined [MU]) was determined using Scorpion ARMS (Therascreen EGFR RGQ kit). EGFR M frequency was calculated and compared between demographic/clinical factor subgroups (chi-square/Fisher’s exact test). Factors with p 〈 0.05 in the univariate analysis were further analyzed by multivariate logistic regression at 1% significance level to take the large dataset into consideration. Results: Of 1482 pts from 7 Asian countries, 43.4% were female, mean age was 60 years (range 17-94), and 52.6% were never-smokers. EGFR M status was evaluated in 1450 patients (32 [2.2%] were MU): 746 (51.4%) were M+, 704 (48.6%) were M-. Country, gender, ethnicity, smoking status, pack years, metastasis, (all p 〈 0.001) and disease stage (p=0.009) correlated significantly with EGFR M status. EGFR M+ rate by country: Vietnam 64.2% (77/120), Taiwan 62.1% (108/174), Thailand 53.8% (63/117), Philippines 52.3% (34/65), China 50.2% (372/741), Hong Kong 47.2% (76/161), India 22.2% (16/72). EGFR M+ rates were 61.1% in females, 44.0% in males, 60.7% in never smokers, and 31.4% in heavy smokers ( 〉 50 pack years). EGFR M+ rates were 37.5% in male regular smokers (113/301), 34.8% in female regular smokers (8/23), 56.5% in male never smokers (104/184) and 62.0% in female never smokers (358/577). Ethnic group (p 〈 0.001) and pack years (p 〈 0.001) were identified as important factors by logistic regression; gender was not significant when adjusted for smoking status. Conclusions: The overall EGFR M+ rate in unselected ADC was 51.4%. Ethnicity and pack years were found to have a statistically significant association with EGFR M rates. There was no association between gender and EGFR M rates when adjusted for smoking status.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2012.30.15_suppl.1534
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2012
detail.hit.zdb_id:
2005181-5
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