In:
British Journal of Nutrition, Cambridge University Press (CUP), Vol. 96, No. 2 ( 2006-08), p. 365-370
Abstract:
Taurine deficiency in patients on long-term parenteral nutrition may be involved in cholestasis. We aimed to assess plasma taurine and tauro-conjugated bile acids in adults with short-bowel syndrome and their response to intravenous taurine. Thirty-two adult patients, who had been on taurine-free parenteral nutrition for a mean of 59(SE14) months for short-bowel syndrome, were studied retrospectively. In a second study, a subgroup of ten patients with chronic cholestasis received taurine-enriched (6·0(SE0·6)mg/kg per d) parenteral nutrition for 55(SE13) months. Post-absorptive plasma taurine and bile acid concentrations were measured and liver function tests routinely sampled. At baseline, plasma taurine was lower in patients with a jejunal length of less than 35cm (group A, n 16) than in those with a jejunal length of 35cm or more (group B, n 16): 43(SE3) v . 58(SE4)μmol/l ( P =0·01). The groups were no different in terms of chronic cholestasis (1/6 v .1/6 patients), total bile acids (26(SE13) v .14(SE5)μmol/l) or the ratio of tauro-conjugated:glyco-conjugated bile acids (5(SE2) v .8(SE 4)%, usual range 30–60%). After supplementation, there was an increase in plasma taurine level (63(SE8) v . 43(SE4), P =0·007) but was no change in either total bile acids or the ratio of tauro-conjugated: glyco-conjugated bile acids. There was a significant decrease in aspartate aminotransferase level. Long-term parenteral nutrition for short-bowel syndrome is associated with an impaired tauro-conjugation of bile acids (enterohepatic pool), irrespective of plasma taurine level (systemic pool) and despite long-term taurine intravenous supplementation.
Type of Medium:
Online Resource
ISSN:
0007-1145
,
1475-2662
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2006
detail.hit.zdb_id:
2016047-1
SSG:
12
SSG:
21
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