In:
Macromolecular Rapid Communications, Wiley, Vol. 44, No. 4 ( 2023-02)
Abstract:
In photodynamic therapy (PDT), the uses of nanoparticles bearing photosensitizers (PSs) can overcome some of the drawbacks of using a PS alone (e.g., poor water solubility and low tumor selectivity). However, numerous nano‐formulations are developed by physical encapsulation of PSs through Van der Waals interactions, which have not only a limited load efficiency but also some in vivo biodistribution problems caused by leakage or burst release. Herein, polymersomes made from an amphiphilic block copolymer, in which a PS with aggregation‐induced emission (AIE‐PS) is covalently attached to its hydrophobic poly(amino acid) block, are reported. These AIE‐PS polymersomes dispersed in aqueous solution have a high AIE‐PS load efficiency (up to 46% as a mass fraction), a hydrodynamic diameter of 86 nm that is suitable for in vivo applications, and an excellent colloidal stability for at least 1 month. They exhibit a red/near‐infrared photoluminescence and ability to generate reactive oxygen species (ROS) under visible light. They are non‐cytotoxic in the dark as tested on Hela cells up to concentration of 100 µ m . Benefiting from colloidal stability, AIE property and ROS generation capability, such a family of polymersomes can be great candidates for image‐guided PDT.
Type of Medium:
Online Resource
ISSN:
1022-1336
,
1521-3927
DOI:
10.1002/marc.202200716
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1475027-2
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