In:
Zeitschrift für Naturforschung B, Walter de Gruyter GmbH, Vol. 76, No. 3-4 ( 2021-04-27), p. 163-171
Abstract:
Two series of sulfonylureas derivatives including 24 compounds ( 4 , 7 , 5a – 5o , 8a – 8h ), among them 17 new derivatives, have been synthesized and evaluated for their α -glucosidase inhibitory activity. Compounds 5c , 5h and 8e showed significant in vitro α -glucosidase inhibition with IC 50 values of 5.58, 79.85 and 213.36 µ m , respectively, comparing with the standard compounds acarbose (IC 50 = 268.29 µ m) and glipizide (IC 50 = 300.47 µ m ). The preliminary structure-activity relationships (SARs) of the synthesized compounds were also investigated.
Type of Medium:
Online Resource
ISSN:
1865-7117
,
0932-0776
DOI:
10.1515/znb-2020-0134
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2021
detail.hit.zdb_id:
2078109-X
detail.hit.zdb_id:
124635-5
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