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  • 1
    Online Resource
    Online Resource
    Findings from the first colorectal cancer screening among 103 542 individuals in Vietnam with systematic review of colorectal cancer screening programs in Asia-Pacific region
    Oxford University Press (OUP) ; 2022
    In:  Japanese Journal of Clinical Oncology Vol. 52, No. 7 ( 2022-07-08), p. 707-715
    Details
    In: Japanese Journal of Clinical Oncology, Oxford University Press (OUP), Vol. 52, No. 7 ( 2022-07-08), p. 707-715
    Abstract: Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vietnam. Although screening is considered an effective measure to prevent and control colorectal cancer, there is no such effort in Vietnam. Methods Between 01 January 2018 and 31 October 2019, a population-based colorectal cancer screening program was conducted in Hanoi, Vietnam. A health advocacy campaign and follow-up phone calls were used to enroll residents aged ≥40 years old to complete an immunochemical-fecal occult blood testing. Positive immunochemical-fecal occult blood testing was followed by a colonoscopy. We also conducted a systematic review of the colorectal cancer screening programs in the Asia-Pacific region that used similar approach by searching Ovid Medline and PubMed databases. Results During study period, 103 542 individuals among 672 742 eligible residents attended the screening of whom 81.5% participants finished immunochemical-fecal occult blood testing test and the positive rate was 6.1%. The coverage rate for immunochemical-fecal occult blood testing test was 11.9%. Among 2278 individuals who underwent colonoscopy, 3.5% were histologically diagnosed with cancer, 17.8% with advanced adenomas, and 23.1% with non-advanced adenomas. Males had significantly higher detection rate of advanced adenomas, cancer or ≥ two polyps/tumor than females (P  & lt; 0.0001). The systematic review showed that in two-step modality (i.e. immunochemical-fecal occult blood testing/fecal immunochemical test and colonoscopy), the test positive was from 4.1 to 10.6%. Once colonoscopy was performed subsequently, the rate of cancer among positive participants was from 1.7 to 16.4% and that of advanced adenomas was from 7.1 to 23.1%. Conclusion We showed that the two-step modality is a promising strategy for colorectal cancer screening in Vietnam that might apply to similar settings with limited resources
    Type of Medium: Online Resource
    ISSN: 1465-3621
    URL: Article
    DOI: 10.1093/jjco/hyac043
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1494610-5
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  • 2
    Online Resource
    Online Resource
    Association between Sleep Duration and Colorectal Adenomas: Findings from a Case–Control Study in Vietnam
    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 32, No. 9 ( 2023-09-01), p. 1160-1168
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 32, No. 9 ( 2023-09-01), p. 1160-1168
    Abstract: Colorectal cancer is one of the leading cancers worldwide and in Vietnam. Adenomas are important precursors of colorectal cancer. Study on the association between sleep duration and development of colorectal adenoma (CRA) is limited, particularly among Vietnamese population. Methods: We conducted an individually matched case–control study of 870 CRA cases and 870 controls in a large-scale colorectal screening program involving 103,542 individuals ages ≥40 years old in Hanoi, Vietnam. Sleep duration was categorized in three groups: short: ≤6 hours/day, normal: 7 to 8 hours/day, and long: & gt;8 hours/day. Conditional logistic regression was used to evaluate the association between sleep duration and adenomas risk after controlling for potential confounders. Results: Overall, short-sleep duration was associated with increased risk of having CRA compared with normal duration [OR, 1.48; 95% confidence interval (CI), 1.12–1.97]. This pattern was present in both females (OR, 1.58; 95% CI, 1.14–2.18) and males (OR, 1.45; 95% CI, 1.08–1.93), with advanced adenomas (OR, 1.61; 95% CI, 1.09–2.38) and non-advanced adenomas (OR, 1.66; 95% CI, 1.19–2.32). Furthermore, the association between CRA development and short-sleep duration was more apparent among females who were nondrinker, nonobese, physically active, with proximal or both sided adenomas and with cardiometabolic disorder. Among males, the short-sleep duration was associated with CRA risk among never-smoking, cardiometabolic disorders, and obese. Conclusions: Short-sleep duration was associated with increased prevalence of both advanced and non-advanced CRAs among Vietnamese population. Impact: Findings from this study showed that maintaining an adequate sleep duration may have an important implication for colorectal adenoma prevention and control.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-23-0056
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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  • 3
    Online Resource
    Online Resource
    Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam
    Wiley ; 2021
    In:  International Journal of Cancer Vol. 149, No. 11 ( 2021-12), p. 1898-1909
    Details
    In: International Journal of Cancer, Wiley, Vol. 149, No. 11 ( 2021-12), p. 1898-1909
    Abstract: What's new? High body mass index (BMI) has been associated with an increased risk of colorectal adenomas in studies including Asian populations. To date, no study has identified modifiable risk factors for colorectal adenomas in Vietnam, a country with a rising colorectal cancer incidence and low obesity prevalence. This case‐control study based on a large‐scale colorectal cancer screening program in Vietnam reports a potential association between underweight and colorectal adenomas prevalence with an inverse J‐shape. The modification of specific factors such as maintaining a normal BMI range, quitting smoking and exercising regularly showed great potential for colorectal cancer prevention and control programs.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v149.11
    DOI: 10.1002/ijc.33757
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 4
    Online Resource
    Online Resource
    Associations between Ileal Juice Bile Acids and Colorectal Advanced Adenoma
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 13 ( 2023-06-28), p. 2930-
    Details
    In: Nutrients, MDPI AG, Vol. 15, No. 13 ( 2023-06-28), p. 2930-
    Abstract: Background: There is an urgent need to identify biomarkers for advanced adenoma, an important precursor of colorectal cancer (CRC). We aimed to determine alterations in ileal juice bile acids associated with colorectal advanced adenoma. Methods: We quantified a comprehensive panel of primary and secondary bile acids and their conjugates using an ultraperformance liquid chromatography triple-quadrupole mass spectrometric assay in ileal juice collected at colonoscopy from 46 study subjects (i.e., 14 biopsy-confirmed advanced adenomas and 32 controls free of adenoma or cancer). Using analysis of covariance (ANCOVA), we examined the differences in bile acid concentrations by disease status, adjusting for age, sex, body mass index, smoking status and type 2 diabetes. Results: The concentrations of hyodeoxycholic acid (HCA) species in ileal juice of the advanced adenoma patients (geometric mean = 4501.9 nM) were significantly higher than those of controls (geometric mean = 1292.3 nM, p = 0.001). The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls (0.73% in cases vs. 1.33% in controls; p = 0.046). No significant difference between cases and controls was observed for concentrations of total or specific primary bile acids (i.e., cholic acid (CA), chenodeoxycholic acid (CDCA) and their glycine- and taurine-conjugates) and total and specific major secondary bile acids (i.e., deoxycholic acid and lithocholic acid). Conclusions: Colorectal advanced adenoma was associated with altered bile acids in ileal juice. The HCA species may promote the development of colorectal advanced adenoma, whereas gut microbiota responsible for the conversion of CDCA to UDCA may protect against it. Our findings have important implications for the use of bile acids as biomarkers in early detection of colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu15132930
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518386-2
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  • 5
    Online Resource
    Online Resource
    Attributable Causes of Cancer in Vietnam
    American Society of Clinical Oncology (ASCO) ; 2020
    In:  JCO Global Oncology , No. 6 ( 2020-11), p. 195-204
    Details
    In: JCO Global Oncology, American Society of Clinical Oncology (ASCO), , No. 6 ( 2020-11), p. 195-204
    Abstract: Vietnam is undergoing rapid socio-economic transition with an increasing cancer burden. The contribution of modifiable risk factors to cancers in Vietnam has not been studied. Therefore, we sought to evaluate the attributable causes of cancer in Vietnam. METHODS We reviewed the data on burden of cancer in Vietnam from 2 cancer registries in Hanoi and Ho Chi Minh City between 1995 and 2012. Next, we calculated the fractions of cancers occurring in 2018 attributable to established modifiable risk factors whose impact could be quantified. Data on exposure prevalence were obtained for the period from 2000 to 2010 from national sources wherever possible. RESULTS Cancer incidence in Vietnam has decreased slightly in both sexes. Cancer related to infectious agents decreased sharply, whereas cancer related to nutrition and metabolism has increased. In 2018, established carcinogens included in the analysis explained 47.0% of cancer burden in Vietnam. Chronic infections accounted for 29.1% of cancers (34.7% in men and 22.1% in women), tobacco smoking for 13.5% (23.9% in men and 0.8% in women), and alcohol drinking for 10.3%. Passive smoking was responsible for 8.8% of cancers in women. Other risk factors, including overweight or obesity, nulliparity, and low vegetable and fruit intake, accounted for 〈 1% of all cancers each. CONCLUSION Cancer incidence is slowly decreasing in Vietnam, and the causes of more than half of cancers remain unexplained. This result underlines the need for further epidemiologic and fundamental research. Our findings confirm the notion that controlling oncogenic infections and decreasing tobacco smoking are the most effective approaches to reduce the burden of cancer in Vietnam, but other risk factors, including alcohol drinking and diet, should not be neglected.
    Type of Medium: Online Resource
    ISSN: 2687-8941
    URL: Article
    DOI: 10.1200/JGO.19.00239
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 3018917-2
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  • 6
    Online Resource
    Online Resource
    Abstract 1217: The association between birth order and childhood brain tumors: A systematic review and meta-analysis
    American Association for Cancer Research (AACR) ; 2018
    In:  Cancer Research Vol. 78, No. 13_Supplement ( 2018-07-01), p. 1217-1217
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 78, No. 13_Supplement ( 2018-07-01), p. 1217-1217
    Abstract: Background: The incidence of childhood brain tumors (CBT) has increased worldwide, likely resulting from the improvements of early diagnostics. The only known risk factors for CBT are the Li-Fraumeni syndrome and iodization. While both genetic and environmental factors are suggested roles in CBT, birth characteristics, including birth order, maternal age, and mode of delivery, might present the interactions between genetic susceptibility and perinatal environmental causes. Birth order has been hypothesized to play an important role in CBT carcinogenesis due to its possible role as proxy for 1) early infection exposure and 2) hormone levels since first pregnancy differs endocrinologically from later pregnancies. We conducted a systematic review and meta-analysis to clarify the association between birth order and CBT. Methods: We followed established guidelines to systematically search OvidMedline, PubMed, and the Cochrane Library for English-language studies (both case-control and cohort designs) published prior to November 2017. Meta-analysis provided pooled risk estimates and their 95% confidence intervals (CI) for birth order and CBT. Funnel plots were used to identify sources of heterogeneity and publication bias. Results: We identified 16 case-control studies with a total sample of 32,439 cases and 166,144 controls. Compared to first birth order, the meta-odds ratio (mOR) for second birth order was 1.04 (95% CI 1.01-1.07), and that for third birth order was 0.98 (95% CI: 0.90-1.06). We also identified 3 cohorts comprising a total of 1,208 cases. The meta-hazard ratio (mHR) for second or higher birth order compared to first birth order was 1.00 (95% CI: 0.96-1.05). Conclusions: We found no overall association between birth order and CBT in both case-control and cohort study designs; the small association observed for second birth order in case-control studies deserves further consideration. Limited statistical power might have hampered the results of the other analyses. Citation Format: Mai V. Nguyen, Mo Thi Tran, Chi TDu Tran, Quang H. Tran, Thuy Thi-Van Tuong, Linh C. Le, Paolo Boffetta, Hung N. Luu. The association between birth order and childhood brain tumors: A systematic review and meta-analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstra ct nr 1217.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2018-1217
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2018
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 7
    Online Resource
    Online Resource
    The Effect of a Multi-Level Intervention on the Initiation of Antiretroviral Therapy (ART) among HIV-Infected Men Who Inject Drugs and Were Diagnosed Late in Thai Nguyen, Vietnam
    Public Library of Science (PLoS) ; 2016
    In:  PLOS ONE Vol. 11, No. 8 ( 2016-8-31), p. e0161718-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 8 ( 2016-8-31), p. e0161718-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0161718
    DOI: 10.1371/journal.pone.0161718.g001
    DOI: 10.1371/journal.pone.0161718.t001
    DOI: 10.1371/journal.pone.0161718.t002
    DOI: 10.1371/journal.pone.0161718.t003
    DOI: 10.1371/journal.pone.0161718.s001
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2016
    detail.hit.zdb_id: 2267670-3
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  • 8
    Online Resource
    Online Resource
    Tuân thủ điều trị ARV và một số yếu tố liên quan trên nhóm bệnh nhân điều trị ARV tại Trung tâm phòng chống HIV/AIDS tỉnh Quảng Bình 2018
    Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM) ; 2021
    In:  Tạp chí Y học Dự phòng Vol. 31, No. 8 ( 2021-11-01), p. 139-149
    Details
    In: Tạp chí Y học Dự phòng, Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM), Vol. 31, No. 8 ( 2021-11-01), p. 139-149
    Abstract: Điều trị bằng thuốc kháng Retrovirus (ARV) là phương pháp hiệu quả nhất với người nhiễm HIV/AIDS. Mục tiêu nghiên cứu nhằm xác định tỷ lệ tuân thủ điều trị (TTĐT) ARV và mô tả một số yếu tố liên quan của bệnh nhân HIV/AIDS. Nghiên cứu sử dụng thiết kế nghiên cứu mô tả cắt ngang, kết hợp định lượng và định tính trên 152 bệnh nhân đang điều trị bằng thuốc ARV tại phòng khám ngoại trú - Trung tâm Phòng chống HIV/AIDS tỉnh Quảng Bình. Kết quả nghiên cứu cho thấy tỷ lệ tuân thủ điều trị trong một tuần qua là 69,1%. Các yếu tố ảnh hưởng đến không TTĐT bao gồm tác dụng phụ của thuốc (OR = 3,21; 95% KTC: 1,03 - 9,96); không tái khám đúng hẹn (OR = 2,89; 95% KTC: 1,23 - 6,67); kiến thức không đạt về điều trị và TTĐT (OR = 2,41; 95% KTC: 1,06 - 5,50); không sử dụng biện pháp nhắc thuốc (OR = 2,6; 95% KTC: 1,05 - 6,41) và tần suất nhận thông tin không thường xuyên (OR = 3,55; 95% KTC: 1,46 - 8,61). Tỷ lệ TTĐT ARV vẫn còn thấp, do đó, cán bộ y tế cần khuyên bệnh nhân tới khám điều trị đúng hẹn, chú trọng nâng cao hiểu biết về TTĐT, các biện pháp hỗ trợ uống thuốc, tác dụng phụ thường xuất hiện và các biện pháp xử trí phù hợp để thực hiện đúng kế hoạch điều trị.
    Type of Medium: Online Resource
    ISSN: 0868-2836
    URL: Article
    DOI: 10.51403/0868-2836/2021/429
    Language: Unknown
    Publisher: Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM)
    Publication Date: 2021
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  • 9
    Online Resource
    Online Resource
    Early Evaluation of an Ultra-Portable X-ray System for Tuberculosis Active Case Finding
    MDPI AG ; 2021
    In:  Tropical Medicine and Infectious Disease Vol. 6, No. 3 ( 2021-09-04), p. 163-
    Details
    In: Tropical Medicine and Infectious Disease, MDPI AG, Vol. 6, No. 3 ( 2021-09-04), p. 163-
    Abstract: X-ray screening is an important tool in tuberculosis (TB) prevention and care, but access has historically been restricted by its immobile nature. As recent advancements have improved the portability of modern X-ray systems, this study represents an early evaluation of the safety, image quality and yield of using an ultra-portable X-ray system for active case finding (ACF). We reported operational and radiological performance characteristics and compared image quality between the ultra-portable and two reference systems. Image quality was rated by three human readers and by an artificial intelligence (AI) software. We deployed the ultra-portable X-ray alongside the reference system for community-based ACF and described TB care cascades for each system. The ultra-portable system operated within advertised specifications and radiologic tolerances, except on X-ray capture capacity, which was 58% lower than the reported maximum of 100 exposures per charge. The mean image quality rating from radiologists for the ultra-portable system was significantly lower than the reference (3.71 vs. 3.99, p 〈 0.001). However, we detected no significant differences in TB abnormality scores using the AI software (p = 0.571), nor in any of the steps along the TB care cascade during our ACF campaign. Despite some shortcomings, ultra-portable X-ray systems have significant potential to improve case detection and equitable access to high-quality TB care.
    Type of Medium: Online Resource
    ISSN: 2414-6366
    URL: Article
    DOI: 10.3390/tropicalmed6030163
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2934690-3
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  • 10
    Online Resource
    Online Resource
    Assessment of some nutrient contents and enzyme activity in early germinating bean of two soybean varieties (Glycine max) DT84 and DT2008
    Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications) ; 2018
    In:  TAP CHI SINH HOC Vol. 40, No. 1 ( 2018-01-25), p. 76-83
    Details
    In: TAP CHI SINH HOC, Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications), Vol. 40, No. 1 ( 2018-01-25), p. 76-83
    Abstract: Soybeans have become widly important and popular due to a high demand of plant protein and fiber. Besides, grains of soybean contain abundance of vitamines, minerals and bioactive compounds such as isoflavone, gama- aminobutyric acid... However, some antinutrient compounds such as tripsin inhibitor and phytate are available in these grains. In this paper, nutrient compounds (protein, lipid, polysaccharide and dissolved minerals) and enzymes of early germinating seeds of soybean varieties (DT84 and DT2008) were evaluated and compared to those of non-germinating beans in order to determine a suitable germinating period for food processing. Experimental results showed that: Activities of enzymes (protease, amylase and phytase) in early germinating soybeans were higher than those in dry beans. Those enzymes have made major changes in nutrient compounds of soybeans: proteins, polysaccharides and lipids reduced. Especially, the content of phytate, an antinutrient factor, reduced signicantly (17.0-48.9% in DT84 variety and 28.0-60.7% in DT2008 variety) during early germinating period of soybeans. However, easy uptake minerals (calcium, iron and zinc ions), reduced sugars and peptides were significantly increased. In detail, the increase in dissolve iron cation was 10.31-12.13%, calcium cation was 31.56-35.75% and zinc cation was 31.38-43.32%. These results confirmed the positive effect of germinating soybeans in food processing.
    Type of Medium: Online Resource
    ISSN: 0866-7160 , 0866-7160
    URL: Article
    DOI: 10.15625/0866-7160/v40n1.10865
    Language: Unknown
    Publisher: Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)
    Publication Date: 2018
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