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  • 1
    Online Resource
    Online Resource
    Nghiên cứu đặc điểm kiểu hình miễn dịch ở bệnh nhân lơ xê mi cấp tại Bệnh viện Trung ương Quân đội 108
    108 Institute of Clinical Medical and Pharmaceutical Sciences ; 2021
    In:  Journal of 108 - Clinical Medicine and Phamarcy Vol. 16, No. DB4 ( 2021-04-01)
    Details
    In: Journal of 108 - Clinical Medicine and Phamarcy, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Vol. 16, No. DB4 ( 2021-04-01)
    Abstract: Mục tiêu: Mô tả đặc điểm dấu ấn miễn dịch ở bệnh nhân lơ xê mi cấp được chẩn đoán tại Khoa Huyết học, Bệnh viện Trung ương Quân đội 108 từ năm 2016 đến năm 2020. Đối tượng và phương pháp: 155 bệnh nhân được chẩn đoán là lơ xê mi cấp (101 nam, 54 nữ), mỗi bệnh nhân được lấy khoảng 0,5 - 1,5ml dịch tuỷ xương và máu ngoại vi sau đó tiến hành phân tích số lượng, công thức, tỷ lệ, đặc tính bằng phương pháp nhuộm giemsa kết hợp hoá học tế bào trên kính hiển vi quang học và phân tích tỷ lệ, dấu ấn miễn dịch tế bào trên hệ thống máy phân tích tế bào dòng chảy FACS Calibur của hãng Becton Dickinson (Mỹ). Kết quả: Tỷ lệ bệnh nhân lơ xê mi cấp dòng tuỷ (AML) và lơ xê mi cấp dòng lympho (ALL) lần lượt là 74,19% và 25,81%. Ở bệnh nhân AML, các tế bào Myeloblast dương tính với CD33, CD117, CD13 và MPO; Monoblast dương tính với CD4, CD14, CD64; Erythroblast dương tính với CD71, Glycophorin A; Megakaryoblast dương tính với CD41. Các bệnh nhân ALL-B dương tính với CD19, Cy79a và một số dương tính với CD10; ALL-T dương tính với CD 3, CD4, CD5, CD7 và CyCD3. Kết luận: Đặc điểm dấu ấn miễn dịch ở bệnh nhân lơ xê mi cấp tại Bệnh viện Trung ương Quân đội 108 từ tháng 01/2016 đến tháng 11/2020 chủ yếu là dòng tuỷ, có thể phân loại tới các dòng tế bào cụ thể và có gặp cả lơ xê mi cấp 2 dòng tế bào B và T.
    Type of Medium: Online Resource
    ISSN: 1859-2872
    URL: Issue
    URL: Article
    DOI: 10.52389/ydls.v16iDB4
    DOI: 10.52389/ydls.v16iDB4.946
    Language: Unknown
    Publisher: 108 Institute of Clinical Medical and Pharmaceutical Sciences
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Prevalence, multidrug resistance, and biofilm formation of Vibrio parahaemolyticus isolated from fish mariculture environments in Cat Ba Island, Vietnam
    Korea Disease Control and Prevention Agency ; 2024
    In:  Osong Public Health and Research Perspectives Vol. 15, No. 1 ( 2024-02-29), p. 56-67
    Details
    In: Osong Public Health and Research Perspectives, Korea Disease Control and Prevention Agency, Vol. 15, No. 1 ( 2024-02-29), p. 56-67
    Abstract: Objectives: Vibrio parahaemolyticus is a major foodborne pathogen in aquatic animals and a threat to human health worldwide. This study investigated the prevalence, antimicrobial resistance, antimicrobial resistance genes (ARGs), and biofilm formation of V. parahaemolyticus strains isolated from fish mariculture environments in Cat Ba Island, Vietnam.Methods: In total, 150 rearing water samples were collected from 10 fish mariculture farms in winter and summer. A polymerase chain reaction assay was used to identify V. parahaemolyticus, its virulence factors, and ARGs. The antimicrobial resistance patterns and biofilm formation ability of V. parahaemolyticus strains were investigated using the disk diffusion test and a microtiter plate-based crystal violet method, respectively.Results: Thirty-seven V. parahaemolyticus isolates were recovered from 150 samples. The frequencies of the tdh and trh genes among V. parahaemolyticus isolates were 8.1% and 21.6%, respectively. More than 90% of isolates were susceptible to ceftazidime, cefotaxime, and chloramphenicol, but over 72% were resistant to ampicillin, tetracycline, and erythromycin. Furthermore, 67.57% of isolates exhibited multidrug resistance. The presence of ARGs related to gentamicin (aac(3)-IV), tetracycline (tetA) and ciprofloxacin (qnrA) in V. parahaemolyticus isolates was identified. Conversely, no ARGs related to ampicillin or erythromycin resistance were detected. Biofilm formation capacity was detected in significantly more multidrug-resistant isolates (64.9%) than non-multidrug-resistant isolates (18.9%).Conclusion: Mariculture environments are a potential source of antibiotic-resistant V. parahaemolyticus and a hotspot for virulence genes and ARGs diffusing to aquatic environments. Thus, the prevention of antibiotic-resistant foodborne vibriosis in aquatic animals and humans requires continuous monitoring.
    Type of Medium: Online Resource
    ISSN: 2210-9099 , 2233-6052
    URL: Article
    DOI: 10.24171/j.phrp.2023.0181
    Language: English
    Publisher: Korea Disease Control and Prevention Agency
    Publication Date: 2024
    detail.hit.zdb_id: 2596685-6
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  • 3
    Online Resource
    Online Resource
    Safety and efficacy of internal carotid artery infusion of autologous bone marrow-derived stem cells in subacute middle cerebral artery infarct
    108 Institute of Clinical Medical and Pharmaceutical Sciences ; 2023
    In:  Journal of 108 - Clinical Medicine and Phamarcy ( 2023-02-27)
    Details
    In: Journal of 108 - Clinical Medicine and Phamarcy, 108 Institute of Clinical Medical and Pharmaceutical Sciences, ( 2023-02-27)
    Abstract: Objective: To evaluate the safety and the efficacy of internal carotid artery (ICA) infusion of autologous bone marrow-derived stem cells (BMSC) in subacute middle cerebral artery (MCA) infarct. Subject and method: A prospective, open-label, non-randomized was conducted in patients with MCA infarct, within 7-40 days from onset. Sixty-two patients satisfying the inclusion criteria were enrolled and allocated into either BMSC group (n = 31) or control group (n = 31). Follow-ups were performed at 6 months and 1 year after therapy. Adverse events were noted to conclude safety outcome. The primary efficacy outcomes were percentages of recovered patients with a score of 0 to 2 on the modified Rankin Scale (mRS). The secondary efficacy outcomes were evaluated by the National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), Brunnstrom stages of hand (BRS-H), and infarct volume on head MRI. Result: There were no significant differences in the percentages of noted adverse events. The percentages of the mRS 0-2 in BMSC group were remarkably higher as compared to control group at both 6-month and 1-year follow-up, but not statistically significant (25.8% vs 6.9%, p=0.08 and 26.7 vs 9.7, p=0.1, respectively). BI at 6 months was significantly better in the BMSC group, however no significant differences on other secondary efficacy measures. Conclusion: ICA infusion of BMSC was safe and tolerated in patients with subacute MCA infarct. Although the difference in the primary efficacy outcomes was not statistically significant, a favorable trend was found in BMSC group representing by the BI at 6 months and the percentages of mRS 0-2 at both main follow-ups.
    Type of Medium: Online Resource
    ISSN: 1859-2872
    URL: Issue
    URL: Article
    DOI: 10.52389/ydls.v17iTA
    DOI: 10.52389/ydls.v17iTA.1660
    Language: Unknown
    Publisher: 108 Institute of Clinical Medical and Pharmaceutical Sciences
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Autologous hematopoietic stem cell transplantation to treat systemic lupus erythematosus: The first case in Vietnam
    108 Institute of Clinical Medical and Pharmaceutical Sciences ; 2023
    In:  Journal of 108 - Clinical Medicine and Phamarcy ( 2023-02-27)
    Details
    In: Journal of 108 - Clinical Medicine and Phamarcy, 108 Institute of Clinical Medical and Pharmaceutical Sciences, ( 2023-02-27)
    Abstract: Background: Systemic lupus erythematosus (SLE) is a chronic disease that causes systemic inflammation which affects multiple organs. There is no cure for SLE. Conventional treatment options include antimalarial drugs, corticosteroids, and immune suppressants, but a number of patients are resistant to treatment or suffer from severe side effects. Stem cell transplantation has been used to treat SLE for the past 2 decades. We describe the first Vietnamese patient with refractory SLE who received an autologous hematopoietic stem cell transplant. Case presentation: The patient is a woman who was diagnosed 12 years ago with systemic lupus erythematosus. She was administered corticosteroids and high-dose immunosuppressive medicines, but the condition was refractory, manifesting as severe headache, arthralgia, chronic anemia, severe Cushing's syndrome, and proteinuria. At admission, the SLEDAI score was 28 and proteinuria was 6.7g/l. She received cyclophosphamide and G-CSF for HSCT mobilization. Peripheral blood stem cells were collected and selected for CD34+ cells. Antithymocyte, cyclophosphamide, and rituximab were used in conditioning regimens. The patient was then administered a CD34+ autologous hematopoietic stem cell transfusion with a CD34+ dose of 7.93 x 106 cells/kg body weight, T and B lymphocyte purity of the graft exceeded 99.99%. Post-transplant course was favorable, the patient did not experience serious complications. Recovery of neutrophils on post-HSCT day +9 and platelet on day +12. Six months after stem cell transplantation, the patient's clinical symptoms significantly improved, the SLEDAI score dropped from 28 to 0, and the patient discontinued receiving immunosuppressive drugs. Conclusion: Autologous hematopoietic stem cell transplantation promises to be a new, effective therapeutic method that can be implemented more broadly in Vietnam for SLE patients.
    Type of Medium: Online Resource
    ISSN: 1859-2872
    URL: Issue
    URL: Article
    DOI: 10.52389/ydls.v17iTA
    DOI: 10.52389/ydls.v17iTA.1653
    Language: Unknown
    Publisher: 108 Institute of Clinical Medical and Pharmaceutical Sciences
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Lychee-Derived, Thermotolerant Yeasts for Second-Generation Bioethanol Production
    MDPI AG ; 2022
    In:  Fermentation Vol. 8, No. 10 ( 2022-10-05), p. 515-
    Details
    In: Fermentation, MDPI AG, Vol. 8, No. 10 ( 2022-10-05), p. 515-
    Abstract: Thermotolerant yeasts are widely considered to be alternative strains to traditional yeasts for bioethanol production at high temperatures. In this study, thirty-two yeasts isolated from lychees were screened for thermotolerance, and seven selected isolates were identified as Candida tropicalis (isolates H8, H19, and H23), Meyerozyma guilliermondii (isolates H1 and H12) and Saccharomyces cerevisiae (isolates H10 and H18). They tolerated up to 45 °C, 12% (v/v) ethanol concentration, 10 g/L acetic acid, and 5 g/L furfural, respectively, and produced 47.96 to 70.18 g/L of ethanol from 160 g/L glucose at 40 °C during 48 h of fermentation. Among the evaluated yeasts, M. guilliermondii H1 showed great potential for second-generation bioethanol fermentation with its ability to ferment xylose and arabinose. Under the optimal conditions resulting from a Plackett Burman design and a Box Behnken design, the highest ethanol concentration of 11.12 g/L was produced from 40 g/L substrate-based sugarcane bagasse hydrolysate (non-detoxified hydrolysate) at 40 °C by M. guilliermondii H1. These findings suggested that the newly isolated thermotolerant yeast M. guilliermondii H1 is a good candidate for ethanol production from agricultural wastes.
    Type of Medium: Online Resource
    ISSN: 2311-5637
    URL: Article
    DOI: 10.3390/fermentation8100515
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2813985-9
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  • 6
    Online Resource
    Online Resource
    AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION TO TREAT MYASTHENIA GRAVIS: EXPERIENCE OF A DEVELOPING COUNTRY
    Uniunea Medicala Balcanica ; 2023
    In:  Archives of the Balkan Medical Union Vol. 58, No. 2 ( 2023-07-05), p. 150-157
    Details
    In: Archives of the Balkan Medical Union, Uniunea Medicala Balcanica, Vol. 58, No. 2 ( 2023-07-05), p. 150-157
    Type of Medium: Online Resource
    ISSN: 1584-9244 , 2558-815X
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.31688/ABMU.2023.58.2
    DOI: 10.31688/ABMU
    DOI: 10.31688/ABMU.2023.58.2.08
    Language: Unknown
    Publisher: Uniunea Medicala Balcanica
    Publication Date: 2023
    detail.hit.zdb_id: 2915786-9
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  • 7
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    Online Resource
    Đánh giá hiệu quả huy động tế bào gốc tạo máu từ tủy xương ra máu ngoại vi ở bệnh nhân đa u tủy xương
    108 Institute of Clinical Medical and Pharmaceutical Sciences ; 2022
    In:  Journal of 108 - Clinical Medicine and Phamarcy ( 2022-04-05)
    Details
    In: Journal of 108 - Clinical Medicine and Phamarcy, 108 Institute of Clinical Medical and Pharmaceutical Sciences, ( 2022-04-05)
    Abstract: Mục tiêu: Đánh giá hiệu quả huy động tế bào gốc tạo máu (CD34+) từ tủy xương ra máu ngoại vi ở bệnh nhân đa u tủy xương bằng phác đồ cyclophosphamid (Cy) kết hợp với yếu tố kích thích tăng trưởng dòng bạch cầu hạt (G-CSF) tại Bệnh viện Trung ương Quân đội 108 từ năm tháng 01/2017-12/2021. Đối tượng và phương pháp: Chọn mẫu thuận tiện với 23 bệnh nhân đa u tủy xương có chỉ định huy động tế bào gốc tạo máu từ tủy xương ra máu ngoại vi để ghép tế bào gốc tạo máu tự thân hỗ trợ điều trị. Thiết kế nghiên cứu: Mô tả cắt ngang hồi cứu và tiến cứu. Mỗi bệnh nhân được dùng cyclophosphamid liều 2 - 3g/m2 da vào ngày N0, ngày N3 dùng G-CSF với liều 5µg/kg/12 giờ liên tục tới khi kết thúc huy động. Các chỉ số theo dõi trong quá trình huy động bao gồm: Tổng phân tích tế bào máu bằng máy đếm laser (hàng ngày); xét nghiệm các chỉ số đông máu, sinh hóa cơ bản (trước, trong, sau quá trình huy động); xét nghiệm tế bào gốc tạo máu ở máu ngoại vi được thực hiện sau khi dùng G-CSF khi số lượng bạch cầu đạt trên 4G/L. Tiến hành gạn tách khi số lượng tế bào gốc tạo máu ở máu ngoại vi 〉 10 tế bào/µl. Kết quả: Tuổi trung bình của bệnh nhân nghiên cứu là 51,78 ± 8,69 tuổi, tổng số ngày huy động trung bình là 8,96  ± 2,43 ngày và số ngày tách để đạt được liều tế bào cần thiết là 1,74 ± 0,62 ngày. Tỷ lệ huy động thành công 23/23 = 100%. Số lượng bạch cầu và tỷ lệ thành phần bạch cầu đều có sự thay đổi rõ rệt giữa ngày tách so với trước huy động. Có sự tương quan thuận, chặt chẽ giữa số lượng tế bào gốc tạo máu ở máu ngoại vi và số lượng tế bào gốc tạo máu trong túi sản phẩm thu được (p 〈 0,001, r = 0,86). Giảm số lượng bạch cầu đoạn trung tính và tiểu cầu ở các mức độ khác nhau là tác dụng phụ hay gặp nhất trong quá trình huy động và phục hồi sau khi kết thúc huy động. Kết luận: Đánh giá bước đầu quá trình huy động tế bào gốc tạo máu từ tủy xương ra máu ngoại vi ở bệnh nhân đa u tủy xương tại Bệnh viện Trung ương Quân đội 108 bằng phác đồ cyclophosphamid + G-CSF đạt hiệu quả cao và tương đối an toàn.
    Type of Medium: Online Resource
    ISSN: 1859-2872
    URL: Issue
    URL: Article
    DOI: 10.52389/ydls.v17i3
    DOI: 10.52389/ydls.v17i3.1196
    Language: Unknown
    Publisher: 108 Institute of Clinical Medical and Pharmaceutical Sciences
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    The role of supervisory mechanisms in improving financial reporting quality by Vietnam public non-business unit
    Informa UK Limited ; 2022
    In:  Cogent Business & Management Vol. 9, No. 1 ( 2022-12-31)
    Details
    In: Cogent Business & Management, Informa UK Limited, Vol. 9, No. 1 ( 2022-12-31)
    Type of Medium: Online Resource
    ISSN: 2331-1975
    URL: Article
    DOI: 10.1080/23311975.2022.2112538
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2837523-3
    SSG: 3,2
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  • 9
    Online Resource
    Online Resource
    Study of stability of the vehicle body during rotation with the air suspension
    GSC Online Press ; 2023
    In:  World Journal of Advanced Research and Reviews Vol. 17, No. 3 ( 2023-3-30), p. 001-008
    Details
    In: World Journal of Advanced Research and Reviews, GSC Online Press, Vol. 17, No. 3 ( 2023-3-30), p. 001-008
    Abstract: This article deals with the problem of controlling the stiffness of the air suspension system to help stabilize the body when the vehicle is moving around. Through the simulation of the change of the suspension stiffness parameter using Matlab simulink software, this paper has shown the impact of external force on the change of air suspension stiffness through simulation graphs. Based on the specifications of the Thaco Mobihome vehicle, simulation results have shown that there is a control to change the air suspension stiffness to help the vehicle move more stably and safely in the horizontal direction when the vehicle is moving around. From the results of this study, it has also been shown that the application of air suspension system for passenger cars will completely improve the level of stability and safety for passengers.
    Type of Medium: Online Resource
    ISSN: 2581-9615
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.30574/wjarr.2023.17.3
    DOI: 10.30574/wjarr
    DOI: 10.30574/wjarr.2023.17.3.0336
    Language: Unknown
    Publisher: GSC Online Press
    Publication Date: 2023
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  • 10
    Online Resource
    Online Resource
    Purification of CD34+ cells in myasthenia gravis patient’s peripheral blood stem cells using the CliniMACS cell separation system
    108 Institute of Clinical Medical and Pharmaceutical Sciences ; 2021
    In:  Journal of 108 - Clinical Medicine and Phamarcy Vol. 16, No. TA ( 2021-12-13)
    Details
    In: Journal of 108 - Clinical Medicine and Phamarcy, 108 Institute of Clinical Medical and Pharmaceutical Sciences, Vol. 16, No. TA ( 2021-12-13)
    Abstract: Autologous hematopoietic stem cell transplantation therapy has been widely used in recent decades for the treatment of hematological diseases, cancer, and autoimmune diseases. In autoimmune diseases, self-activated T lymphocytes and B lymphocytes secreting antibodies against host antigens are considered to be central in the pathogenesis of the disease. Autologous stem cell products that eliminates these pathological cells could be a lifesaver for patients with autoimmune diseases who are resistant to conventional therapy, in order to restore a healthy immune system, achieve long-term remission and limited recurrence. The aims of this study was to complete and evaluate the results of the CD34 positive stem cells purification procedure from a myasthenia gravis patient’s mobilized peripheral blood stem cells, for the purpose of autologous hematopoietic stem cell transplantation for Myasthenia gravis as well as other autoimmune diseases in Vietnam. We have completed the purification procedure of CD34-positive stem cells from mobilized peripheral blood stem cells of patient with myasthenia gravis using CliniMACS system with results of removing 99.99% of T lymphocytes; 99.81% of B lymphocytes; 99.99% of NK cells, while CD34+ recovery performance was 64.05% with CD34+ cell survival rate of over 99%, no bacterial contamination, ensuring quality assurance of stem cell product for transplantation.
    Type of Medium: Online Resource
    ISSN: 1859-2872
    URL: Issue
    URL: Article
    DOI: 10.52389/ydls.v16iTA
    DOI: 10.52389/ydls.v16iTA.1123
    Language: Unknown
    Publisher: 108 Institute of Clinical Medical and Pharmaceutical Sciences
    Publication Date: 2021
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