In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 24_Supplement ( 2011-12-15), p. P2-01-24-P2-01-24
Abstract:
Background: Triple-negative breast cancers (TNBC) are defined as tumors that lack expression of estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type 2 (HER2). Majority of TNBC (approximately 80%) are basal-like breast cancers. The question of whether there is a specific, identifiable cell in the normal breast form which basal-like breast cancers arise is controversial. We evaluated the frequency and receptor status of ductal carcinoma in situ (DCIS) and ductal components associated with T1 invasive ductal carcinoma (IDC) to clarify the developmental pathway of TNBC. Methods: From our institutional archives between April 2000 and April 2011, we retrieved 758 cases of DCIS and T1 invasive ductal carcinoma without prior operative treatment. Immunohistochemistry for ER, PgR and HER2 was performed on ductal components and invasive components. Statistical analysis was performed using Fisher Extract Test. Results: The frequencies of triple-negative (TN) subtype at each size were not seen significant differences. Ductal components were seen in 51 (84%) TN-IDC cases. Within 51 cases, the ductal components were TN in 49 cases. The remaining 3 cases were positive for ER and PgR, but negative HER2. Conclusion: The resemblance between ductal components and invasive components and the coincident frequency of TNBC at each size sustain the hypothesis that TNBC arise from the luminal progenitor compartment. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-01-24.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/0008-5472.SABCS11-P2-01-24
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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