In:
European Journal of Cancer Prevention, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 6 ( 2018-11), p. 521-529
Abstract:
Several epidemiological studies have investigated the relationship between height and risk of colorectal cancer (CRC), but the results were inconsistent. Thus, a meta-analysis of observational studies was carried out to clarify this association. A literature search was performed in PubMed and Web of Science databases for all relevant studies up to 25 May 2016. The random-effects model was used to calculate the pooled relative risks (RRs) and restricted cubic spline model was adopted for the dose–response analysis. A total of 31 studies involving 13 077 848 participants with 93 818 cases were included. The pooled RR (95% confidence interval) of CRC for the highest versus the lowest category of height was 1.25 (1.18–1.32); the pooled RR was 1.32 (1.22–1.43) for colon cancer and 1.12 (1.05–1.19) for rectal cancer for the highest versus the lowest category of height. A nonlinear relationship was found between height and the risk of CRC in the dose–response analysis ( P nonlinearity =0.0024). This meta-analysis indicates that height is associated with an increased risk of CRC.
Type of Medium:
Online Resource
ISSN:
0959-8278
DOI:
10.1097/CEJ.0000000000000390
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2018
detail.hit.zdb_id:
1137033-6
detail.hit.zdb_id:
2025799-5
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