In:
International Journal of Cancer, Wiley, Vol. 134, No. 9 ( 2014-05), p. 2189-2198
Abstract:
What's new? The identification of biomolecules associated with hepatocellular carcinoma (HCC) could greatly improve screening for early disease detection. Ubiquitous mitochondrial creatine kinase (uMtCK) could be a promising marker in this context, though its relevance in HCC is unclear, as it may be associated with mitochondrial stability rather than carcinogenesis. Here, in transgenic mice susceptible to the loss of liver mitochondrial integrity, uMtCK was found to be elevated in HCC tissue but not in non‐tumorous liver tissue. Increased uMtCK was further linked to reduced expression of ASB9 and elevated risk for HCC‐related death.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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