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  • 1
    Online Resource
    Online Resource
    PEAK HOME BLOOD PRESSURE AS AN EARLIER AND STRONG NOVEL RISK FACTOR FOR STROKE: THE PRACTITIONER-BASED NATIONWIDE J-HOP STUDY EXTENDED
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Hypertension Vol. 41, No. Suppl 3 ( 2023-06), p. e126-
    Details
    In: Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. Suppl 3 ( 2023-06), p. e126-
    Type of Medium: Online Resource
    ISSN: 0263-6352 , 1473-5598
    URL: Article
    DOI: 10.1097/01.hjh.0000940056.61512.25
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2017684-3
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  • 2
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    Online Resource
    Polysomnography‐derived sleep parameters as a determinant of nocturnal blood pressure profile in patients with obstructive sleep apnea
    Wiley ; 2018
    In:  The Journal of Clinical Hypertension Vol. 20, No. 6 ( 2018-06), p. 1039-1048
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 20, No. 6 ( 2018-06), p. 1039-1048
    Abstract: Obstructive sleep apnea causes blood pressure (BP) surges during sleep, which may lead to increased sleep‐onset cardiovascular events. The authors recently developed an oxygen‐triggered nocturnal BP monitoring system that initiates BP measurements when oxygen desaturation (SpO 2 ) falls below a variable threshold. The association between nocturnal BP parameters obtained by nocturnal BP monitoring and simultaneously examined polysomnography‐derived sleep parameters in 116 patients with obstructive sleep apnea (mean age 57.9 years, 85.3% men) was studied. In multivariable analysis with independent factors of age, body mass index, sex, and polysomnography‐derived measures (apnea‐hypopnea index, apnea index, arousal index, lowest SpO 2 , and SpO 2   〈  90%), apnea‐hypopnea index (β = .26, P  = .02) and lowest SpO 2 (β = −.34, P   〈  .001) were independent determinants of hypoxia‐peak systolic BP (SBP), defined as the maximum SBP value measured by nocturnal BP monitoring. Similarly, apnea‐hypopnea index (β = .21, P  = .04) and lowest SpO 2 (β = −.49, P   〈  .001) were independent determinants of nocturnal SBP surge, defined as the difference between the hypoxia‐peak SBP and the average of the SBP values within 30 minutes before and after the hypoxia‐peak SBP, measured by the fixed‐interval function in the manner of conventional ambulatory BP monitoring. In conclusion, in polysomnography‐derived parameters, lowest SpO 2 , defined as the minimum SpO 2 value during sleep, is the strongest independent determinant of hypoxia‐peak SBP and nocturnal SBP surge measured by nocturnal BP monitoring. Our findings suggest that the severity of the decrease in SpO 2 and the frequency of such decreases would be important indicators to identify high‐risk patients who are likely to develop cardiovascular events specifically during sleep.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.2018.20.issue-6
    DOI: 10.1111/jch.13308
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2058690-5
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  • 3
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    Online Resource
    Effect of suvorexant on nighttime blood pressure in hypertensive patients with insomnia: The SUPER‐1 study
    Wiley ; 2019
    In:  The Journal of Clinical Hypertension Vol. 21, No. 7 ( 2019-07), p. 896-903
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 21, No. 7 ( 2019-07), p. 896-903
    Abstract: Orexins are neuropeptides that play a role in maintaining wakefulness and contribute to central regulation of cardiovascular function. This first multicenter, randomized, double‐blind study investigated the effects of suvorexant, a reversible dual orexin receptor antagonist, on nighttime blood pressure (BP) in patients with insomnia and hypertension. After a 4‐week run‐in period, adult outpatients (n = 82) with treated hypertension (clinic SBP 〈 160 mm Hg) and insomnia were treated with suvorexant 20 mg/d or placebo before bedtime for 2 weeks. Twenty‐four‐hour ambulatory BP monitoring was performed at baseline and the end of treatment, and home BP measurements (morning and evening) were taken daily. Nighttime systolic BP (SBP), the primary endpoint, decreased slightly from baseline to week 2 in both the suvorexant and placebo groups (−4.4 vs −1.8 mm Hg; P  = 0.494). Clinic, 24‐hour, daytime and morning SBP (ambulatory blood pressure monitoring) also decreased slightly and similarly from baseline in both groups. In this study, suvorexant had no overall effect on BP in patients with insomnia and treated hypertension.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.2019.21.issue-7
    DOI: 10.1111/jch.13505
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 4
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    Online Resource
    2020 Consensus summary on the management of hypertension in Asia from the HOPE Asia Network
    Wiley ; 2020
    In:  The Journal of Clinical Hypertension Vol. 22, No. 3 ( 2020-03), p. 351-362
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 22, No. 3 ( 2020-03), p. 351-362
    Abstract: Hypertension professionals from Asia have been meeting together for the last decade to discuss how to improve the management of hypertension. Based on these education and research activities, the Hypertension, brain, cardiovascular and renal Outcome Prevention and Evidence in Asia (HOPE Asia) Network was officially established in June 2018 and includes experts from 12 countries/regions across Asia. Among the numerous research and review papers published by members of the HOPE Asia Network since 2017, publications in three key areas provide important guidance on the management of hypertension in Asia. This article highlights key consensus documents, which relate to the Asian characteristics of hypertension, home blood pressure monitoring (HBPM), and ambulatory blood pressure monitoring (ABPM). Hypertension and hypertension‐related diseases are common in Asia, and their characteristics differ from those in other populations. It is essential that these are taken into consideration to provide the best opportunity for achieving “perfect 24‐hour blood pressure control”, guided by out‐of‐office (home and ambulatory) blood pressure monitoring. These region‐specific consensus documents should contribute to optimizing individual and population‐based hypertension management strategies in Asian country. In addition, the HOPE Asia Network model provides a good example of the local interpretation, modification, and dissemination of international best practice to benefit specific populations.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v22.3
    DOI: 10.1111/jch.13751
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 5
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    Online Resource
    The influence of the ambient temperature on blood pressure and how it will affect the epidemiology of hypertension in Asia
    Wiley ; 2020
    In:  The Journal of Clinical Hypertension Vol. 22, No. 3 ( 2020-03), p. 438-444
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 22, No. 3 ( 2020-03), p. 438-444
    Abstract: Epidemiologic studies have consistently demonstrated an increased risk of cardiovascular disease during colder temperatures. Hemodynamic changes associated with cold temperature and an increase in thrombogenicity may both account for the increase in cardiovascular risk and mortality. Studies using both in‐office and out‐of‐office BP measurements have consistently shown an elevation in BP during the colder seasons. The large difference in BP between cold and warm months may increase the incidence of hypertension and reduce the hypertension control rate, potentially resulting in increased cardiovascular risk, especially among those at risk of cardiovascular disease. The current trends in global warming and climate change may have a profound impact on the epidemiology of hypertension and cardiovascular disease, as changes in the climate may significantly affect both BP variability and cardiovascular disease, especially in those with high cardiovascular risk and the elderly. Furthermore, climate change could have a significant influence on hypertension in Asia, considering the unique characteristics of hypertensive patients in Asia. As an increase in ambient temperature decreases the mean daytime average and morning surge in BP, but increases the nocturnal BP, it is difficult to predict how environmental changes will affect the epidemiology and prognosis of hypertension in the Asian‐Pacific region. However, these seasonal variations in BP could be minimized by adjusting the housing conditions and using anticipation medicine. In this review, we discuss the impact of seasonal variation in the ambient temperature on hypertension and cardiovascular disease and discuss how this may impact the epidemiology of hypertension and cardiovascular disease.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v22.3
    DOI: 10.1111/jch.13762
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 6
    Online Resource
    Online Resource
    Winter morning surge in blood pressure after the Great East Japan Earthquake
    Wiley ; 2019
    In:  The Journal of Clinical Hypertension Vol. 21, No. 2 ( 2019-02), p. 208-216
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 21, No. 2 ( 2019-02), p. 208-216
    Abstract: This study investigated the association between winter morning surge in systolic blood pressure ( SBP ) as measured by ambulatory BP monitoring and the housing conditions of subjects in an area damaged by the Great East Japan Earthquake. In 2013, 2 years after disaster, hypertensives who lived in homes that they had purchased before the disaster (n = 299, 74.6 ± 8.1 years) showed significant winter morning surge in SBP (+5.0 ± 20.8 mmHg, P  〈   0.001), while those who lived in temporary housing (n = 113, 76.2 ± 7.6 years) did not. When we divided the winter morning surge in SBP into quintiles, the factors of age ≥75 years and occupant‐owned housing were significant determinants for the highest quintile (≥20 mmHg) after adjustment for covariates. The hypertensives aged ≥75 years who lived in their own homes showed a significant risk for the highest quintile (odds ratio 5.21, 95% confidence interval 1.49‐18.22, P  =   0.010). It is thus crucial to prepare suitable housing conditions for elderly hypertensives following a disaster.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.2019.21.issue-2
    DOI: 10.1111/jch.13463
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 7
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    Online Resource
    Diversity of and initiatives for hypertension management in Asia—Why we need the HOPE Asia Network
    Wiley ; 2020
    In:  The Journal of Clinical Hypertension Vol. 22, No. 3 ( 2020-03), p. 331-343
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 22, No. 3 ( 2020-03), p. 331-343
    Abstract: The Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network was set up to improve the management of hypertension in Asia with the ultimate goal of achieving “zero” cardiovascular events. Asia is a diverse continent, and the prevalence of hypertension has increased over the last 30 years. There are a number of Asia‐specific features of hypertension and hypertension‐related cardiovascular complications, which means that a region‐specific approach is needed. White‐coat hypertension will become more of an issue over time as Asian populations age, and masked hypertension is more prevalent in Asian than in Western countries. Identifying and treating masked hypertension is important to reduce cardiovascular risk. Abnormal patterns of blood pressure (BP) variability common in Asia include exaggerated early morning BP surge and nocturnal hypertension. These are also important cardiovascular risk factors that need to be managed. Home blood pressure monitoring (HBPM) is an important tool for detecting white‐coat and masked hypertension, and monitoring BP variability, and practices in Asia are variable. Use of HBPM is important given the Asia‐specific features of hypertension, and strategies are needed to improve and standardize HBPM usage. Development of HBPM devices capable of measuring nocturnal BP along with other information and communication technology‐based strategies are key developments in the widespread implementation of anticipation medicine strategies to detect and prevent cardiovascular events in patients with hypertension. Region‐wide differences in hypertension prevalence, control, and management practices in Asia highlight the importance of information sharing to facilitate best practices.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v22.3
    DOI: 10.1111/jch.13733
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 8
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    Online Resource
    Clinical significance of nocturnal home blood pressure monitoring and nocturnal hypertension in Asia
    Wiley ; 2021
    In:  The Journal of Clinical Hypertension Vol. 23, No. 3 ( 2021-03), p. 457-466
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 23, No. 3 ( 2021-03), p. 457-466
    Abstract: Nocturnal home blood pressure (BP) monitoring has been used in clinical practice for ~20 years. The authors recently showed that nocturnal systolic BP (SBP) measured by a home BP monitoring (HBPM) device in a Japanese general practice population was a significant predictor of incident cardiovascular disease (CVD) events, independent of office and morning home SBP levels, and that masked nocturnal hypertension obtained by HBPM (defined as nocturnal home BP ≥ 120/70 mmHg and average morning and evening BP  〈  135/85 mmHg) was associated with an increased risk of CVD events compared with controlled BP (nocturnal home BP  〈  120/70 mmHg and average morning and evening BP  〈  135/85 mmHg). This evidence revealed that (a) it is feasible to use a nocturnal HBPM device for monitoring nocturnal BP levels, and (b) such a device may offer an alternative to ambulatory BP monitoring, which has been the gold standard for the measurement of nocturnal BP. However, many unresolved clinical problems remain, such as the measurement schedule and conditions for the use of nocturnal HBPM. Further investigation of the measurement of nocturnal BP using an HBPM device and assessments of the prognostic value are thus warranted. Asians are at high risk of developing nocturnal hypertension due to high salt sensitivity and salt intake, and the precise management of their nocturnal BP levels is important. Information and communication technology‐based monitoring devices are expected to facilitate the management of nocturnal hypertension in Asian populations.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v23.3
    DOI: 10.1111/jch.14218
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 9
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    Reproducibility of nighttime home blood pressure measured by a wrist‐type nocturnal home blood pressure monitoring device
    Wiley ; 2021
    In:  The Journal of Clinical Hypertension Vol. 23, No. 10 ( 2021-10), p. 1872-1878
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 23, No. 10 ( 2021-10), p. 1872-1878
    Abstract: The authors investigated the reproducibility of nighttime home blood pressure (BP) measured by a wrist‐type BP monitoring device. Forty‐six hypertensive patients (mean 69.0±11.6 years, 56.5% male) self‐measured their nighttime BP hourly using simultaneously worn wrist‐type and upper arm‐type nocturnal home BP monitoring devices at home on two consecutive nights. Using the average 7.4±1.3 measurements on the first night and the average 7.0 ± 1.8 measurements on the second night, the authors assessed the reliability and the reproducibility of nighttime BP measured on the two nights. The difference between nights in systolic BP (SBP) measured by the wrist‐device was not significant (1.6±7.0 mmHg, p  = .124), while the difference in diastolic BP (DBP) was marginally significant (1.4±4.9 mmHg, p  = .050). The intraclass correlation coefficients (ICCs) for agreement between nights were high both in SBP and DBP average (SBP: 0.835, DBP: 0.804). Averaging only three points of SBP resulted in lower ICC values, but still indicated good correlations (ICC  〉  0.6). On the other hand, the correlations of the standard deviation and average real variability of SBP between nights were low, with ICCs of 0.220 and 0.436, respectively. In conclusion, the average SBP values measured on the first night were reliable even when averaging only three readings. The reproducibility of nighttime BP variability seemed inferior to that of BP average; it might be better to measure nighttime BP over multiple nights to assess BP variability. However, this hypothesis needs verification in other study population. In addition, our study population had well‐controlled BP, which limits the generalizability of this findings to all hypertensive patients.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v23.10
    DOI: 10.1111/jch.14342
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 10
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    Online Resource
    Effect of canagliflozin on nocturnal home blood pressure in Japanese patients with type 2 diabetes mellitus: The SHIFT‐J study
    Wiley ; 2018
    In:  The Journal of Clinical Hypertension Vol. 20, No. 10 ( 2018-10), p. 1527-1535
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 20, No. 10 ( 2018-10), p. 1527-1535
    Abstract: Sodium‐glucose cotransporter 2 (SGLT2) inhibitors have beneficial effects on several cardiometabolic biomarkers, but this is not sufficient to fully explain the significant reduction in cardiovascular risk and mortality reported with SGLT2 inhibitor treatment in patients with diabetes mellitus. The 8‐week, randomized, open‐label SHIFT‐J study investigated the effects of adding canagliflozin vs intensified antihyperglycemic therapy on nocturnal home blood pressure (BP) in patients with poorly controlled type 2 diabetes and nocturnal BP on existing therapy. Patients were randomized to oral canagliflozin 100 mg/d or control (increased hypoglycemic dosage/addition of another hypoglycemic agent). The efficacy analysis included 78 patients (mean 69 years; 59% male). Nocturnal home systolic BP [HSBP] decreased by 5.23 mm Hg in the canagliflozin group and by 1.04 mm Hg in the control group ( P = 0.078 for between‐group difference in change from baseline to week 8 [primary endpoint]); corresponding decreases in HSBP from baseline to week 4 were 5.08 and 1.38 mm Hg, respectively ( P = 0.054). Reductions in morning HSBP from baseline to week 4 (−6.82 mm Hg vs −1.26 mm Hg, P = 0.038) and evening HSBP from baseline to week 8 (−8.74 mm Hg vs −2.36 mm Hg, P = 0.012) were greater in the canagliflozin group than in the control group. Body mass index ( P 〈 0.001) and N‐terminal pro B‐type natriuretic peptide level (NT‐proBNP; P = 0.023) decreased more in the canagliflozin group than in the control group. Glycemic control improved comparably in both groups. Reduction of HSBP and NT‐proBNP level may be potential mechanism by which SGLT2 inhibitors reduce cardiovascular event risk.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.2018.20.issue-10
    DOI: 10.1111/jch.13367
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2058690-5
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