In:
Pathology International, Wiley, Vol. 63, No. 7 ( 2013-07), p. 339-344
Abstract:
The basic region–leucine zipper ( bZip ) factor BTB , CNC homology 2 ( BACH 2) is known to have important roles in class switch recombination and somatic hypermutation ( SHM ) of the immunoglobulin ( I g) gene. In this study, we investigated the relationship between the expression of BACH 2 and the status of SHM of the I g heavy chain gene variable region ( IgHV ) for SHM in diffuse large B ‐cell lymphoma ( DLBCL ). We examined 20 cases of DLBCL , 13 of which were germinal center B ‐cell ( GCB ) DLBCL and 7 were non‐ GCB DLBCL . Seven cases were negative, 6 were positive (cytoplasmic expression) and 7 were strongly positive (both nuclear and cytoplasmic expression) for BACH 2. Confirmed mutation ( CM ) was identified in 8 cases and the CM index (number of confirmed mutations per 10 subclones) was distributed from 0 to 5. A CM index of 7 strongly positive (over‐expression) cases with BACH 2 were distributed from 0 to 5, and that of 7 negative and 6 positive cases were distributed from 0 to 1. Over‐expression of BACH 2 was statistically related to CM index ( P = 0.008). In conclusion, over‐expression of BACH 2 is critical for ongoing SHM of IgHV in DLBCL , and our data suggest that BACH 2 may play an essential role for SHM of the I g gene in B ‐cell lymphoma.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
DOI:
10.1111/pin.2013.63.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2008574-6
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