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  • 1
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 32, No. 4 ( 2004-06), p. 870-880
    Abstract: No studies have dealt with the effect of growth factors on the free tendon autograft in anterior cruciate ligament reconstruction. Hypothesis Application of exogenous transforming growth factor-β and epidermal growth factor may affect the structural properties and histology of the bone-patellar tendon-bone autograft after anterior cruciate ligament reconstruction. Study Design Controlled laboratory study. Methods Twenty dogs underwent anterior cruciate ligament reconstruction with the autogenous bone-patellar tendon-bone graft in bilateral knees. In 10 animals, 12 ng transforming growth factor-β and 300 ng epidermal growth factor mixed with fibrin sealant of 0.6 mL were applied to the left knee. In the remaining 10 dogs, fibrin sealant alone was applied to the left knee. No additional treatments were applied to the right knee. Results The growth factor application increased the stiffness and maximum failure load of the femur-graft-tibia complex at 12 weeks (P = .016 and P = .012, respectively); the sham treatment did not significantly affect them. Histologically, most of the cells in the grafts treated with growth factors had spindle-shaped nuclei; cells in the other grafts had round-shaped nuclei. Conclusions Application of transforming growth factor-β and epidermal growth factor improves the structural properties of the autograft after anterior cruciate ligament reconstruction in the canine model. Clinical Relevance Application of growth factors is a possible strategy to prevent graft deterioration in anterior cruciate ligament reconstruction.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 2
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 34, No. 12 ( 2006-12), p. 1918-1925
    Abstract: Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis. Hypothesis An application of VEGF may enhance angiogenesis in the grafted tendon in anterior cruciate ligament (ACL) reconstruction, and the application may affect mechanical characteristics of the ACL graft. Study Design Controlled laboratory study. Methods Eighteen sheep were divided into groups I and II. In group I, the harvested semitendinosus tendon was soaked in VEGF solution, and the right knee then underwent ACL reconstruction using this tendon. In group II, the right knee underwent identical procedures to those of group I except that the harvested tendon was soaked in phosphate-buffered saline. All animals were sacrificed 12 weeks after ACL reconstruction. Results Histologic findings showed that newly formed vessels and infiltrative fibroblasts were more abundant in group I than in group II. The anterior-posterior translation of the knee during an anterior-posterior force of ±100 N was significantly larger in group I than in group II by 2.58 mm (95% confidence interval, -1.76 mm to 1.76 mm) (P =. 002). The linear stiffness of the femur-graft-tibia complex in group I was significantly lower than that in group II by 41.5 N/mm (95% confidence interval, -32.2 N/mm to 32.2 N/mm) (P=. 017). Conclusion This study has revealed that VEGF as administered in this study promotes angiogenesis in the ACL graft and significantly reduces the stiffness of the ACL graft with increased knee laxity at 12 weeks after ACL reconstruction. Clinical Relevance Exogenous VEGF application for ACL reconstruction can induce an increase in knee laxity and a decrease in the stiffness of the grafted tendon at least temporarily after ACL reconstruction. These potentially negative mechanical effects need to be taken into account when considering clinical use of VEGF.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 2005
    In:  Operative Techniques in Orthopaedics Vol. 15, No. 2 ( 2005-04), p. 96-102
    In: Operative Techniques in Orthopaedics, Elsevier BV, Vol. 15, No. 2 ( 2005-04), p. 96-102
    Type of Medium: Online Resource
    ISSN: 1048-6666
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    detail.hit.zdb_id: 2150384-9
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  • 4
    In: Journal of Sports Science and Medicine, Journal of Sports Science and Medicine
    Abstract: This study aimed to determine the differences in trunk muscle activity during rowing at maximal effort between rowers with and without low back pain (LBP). Ten rowers with LBP and 12 rowers without LBP were enrolled in this study. All rowers performed a 500-m trial using a rowing ergometer at maximal effort. The amplitudes of the activities of the thoracic erector spinae (TES), lumbar erector spinae (LES), latissimus dorsi (LD), rectus abdominis (RA), and external oblique (EO) muscles were analyzed using a wireless surface electromyography (EMG) system. EMG data at each stroke were converted into 10-time series data by recording averages at every 10% in the 100% stroke cycle and normalized by maximum voluntary isometric contraction in each muscle. Two-way repeated measures analysis of variance was performed. Significant interactions were found in the activities of the TES and LES (P 〈 0.001 and P = 0.047, respectively). In the post hoc test, the TES activity in the LBP group was significantly higher than that in the control group at the 10% to 20% and 20% to 30% stroke cycles (P = 0.013 and P = 0.007, respectively). The LES activity in the LBP group was significantly higher than that in the control group at the 0% to 10% stroke cycle (P 〈 0.001). There was a main group effect on the LD activity, with significantly higher activity in the LBP group than in the control group (P = 0.023). There were no significant interactions or main effects in the EO and RA activities between the groups. The present study showed that rowers with LBP compared with those without LBP exhibited significantly higher TES, LES, and LD muscle activities. This indicates that rowers with LBP exhibit excessive back muscle activity during rowing under maximal effort.
    Type of Medium: Online Resource
    ISSN: 1303-2968
    Language: English
    Publisher: Journal of Sports Science and Medicine
    Publication Date: 2023
    detail.hit.zdb_id: 2075564-8
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  • 5
    In: Knee Surgery, Sports Traumatology, Arthroscopy, Springer Science and Business Media LLC, Vol. 16, No. 3 ( 2008-3), p. 333-339
    Type of Medium: Online Resource
    ISSN: 0942-2056 , 1433-7347
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2008
    detail.hit.zdb_id: 1473170-8
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2016
    In:  Knee Surgery, Sports Traumatology, Arthroscopy Vol. 24, No. 4 ( 2016-4), p. 1071-1080
    In: Knee Surgery, Sports Traumatology, Arthroscopy, Springer Science and Business Media LLC, Vol. 24, No. 4 ( 2016-4), p. 1071-1080
    Type of Medium: Online Resource
    ISSN: 0942-2056 , 1433-7347
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 1473170-8
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  • 7
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 1 ( 2022-12-29), p. 270-
    Abstract: The present study aimed to assess the effects of posterior spinal correction and fusion on postural stability in patients with adolescent idiopathic scoliosis (AIS). The study included 41 female patients with AIS at our institution. All patients performed three 10 s single-leg standing trials on a force plate. The center of pressure (COP) was measured preoperatively, and at 1 week and 6 months postoperatively. The postural stability parameters were absolute minimum time-to-boundary (TTB), mean of the minimum TTB, mean COP velocity, standard deviation, range, and 95% confidence ellipse area. One-way repeated analysis of variance or Friedman test was applied to the postural stability parameters. Multiple comparisons were performed using the Bonferroni correction. The absolute minimum TTB and the mean minimum TTB showed a significant increase 6 months post-operation as compared to preoperatively and 1 week postoperatively. The COP velocity significantly decreased at 6 months post-operation compared to preoperatively and 1 week postoperatively. These changes in postural stability indicate that spinal correction and fusion can be considered to improve postural stability during single-leg standing tests in the postoperative period.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662592-1
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  • 8
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 11, No. 9 ( 2023-09)
    Abstract: Return-to-sports (RTS) rates after anterior cruciate ligament (ACL) reconstruction (ACLR) differ according to the level at which patients return. It is unclear whether the level of RTS is affected by psychological readiness to return. Purpose: To examine the association between psychological readiness to RTS and subjective RTS level 12 months after ACLR. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 47 patients who underwent unilateral primary ACLR surgery were enrolled. Assessments at 6 and 12 months postoperatively consisted of knee strength testing (isokinetic quadriceps and hamstring strength), the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC-SKF), and the Anterior Cruciate Ligament-Return to Sport after Injury (ACL-RSI) scale to measure psychological readiness to RTS. Patients were assigned to 1 of 3 subgroups based on their subjective assessment of RTS level at 12 months postoperatively: RTS at or above preinjury level (RTS≥Pre; n = 19), RTS below preinjury level (RTS 〈 Pre; n = 24), or no RTS (n = 4). Two-way mixed-model analysis of variance was used to examine the effects of RTS subgroup, postoperative time point, and group × time interaction with patient characteristics, knee strength, and IKDC-SKF and ACL-RSI scores. Multivariate logistic regression analysis was performed to determine which factors were associated with RTS subgroupings. Results: Significant differences were found among the RTS≥Pre, RTS 〈 Pre, and no-RTS groups in age, ACL-RSI score at 6 and 12 months, quadriceps strength at 6 and 12 months, and IKDC-SKF score at 6 and 12 months ( P  〈  .001 for all). Multivariate logistic regression analysis revealed that RTS at or above preinjury level was associated with higher ACL-RSI score at 12 months postoperatively (odds ratio [OR], 1.11; 95% CI, 1.05-1.20; P = .003) and younger age (OR, 0.80; 95% CI, 0.61-0.92; P = .012). Conclusion: The ACL-RSI score was significantly different among the study groups, and the ACL-RSI score at 12 months postoperatively and younger age were associated with RTS at or above preinjury level.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 9
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 11, No. 6 ( 2023-06-01)
    Abstract: Although double-leg squatting is less dynamic and places less demand on the quadriceps compared with landing tasks, the relationship between double-leg squatting biomechanics and persistent quadriceps weakness after anterior cruciate ligament reconstruction (ACLR) is unknown. Purpose: To clarify the relationships between asymmetries in quadriceps strength and lower limb biomechanics during double-leg squatting 〉 1 year after ACLR. Study Design: Controlled laboratory study. Methods: A total of 26 participants (5.5 ± 3.8 years after ACLR) were enrolled. The limb symmetry index (LSI) of isokinetic quadriceps strength was used to divide participants into the high-quadriceps (HQ) group (LSI ≥90%; n = 18) and the low-quadriceps (LQ) group (LSI 〈 90%; n = 8). The knee, hip, and ankle extension moment (relative to body weight and support moment [sum of knee, hip, and ankle moments]) and vertical ground-reaction force during double-leg squatting were analyzed using 3-dimensional motion analysis. The association of quadriceps strength and biomechanical variables was tested using 2-way analysis of variance and univariate regression analysis. Results: A significant group-by-limb interaction was found for the peak knee extension moment and the ratios of knee and hip extension moment to support moment ( P 〈 .001, P = .015 and P 〈 .001, respectively). The LQ group showed a significantly smaller peak knee extension moment and knee to support moment ratio but a larger hip to support moment ratio in the involved limb than in the uninvolved limb (95% CIs: knee extension moment, −0.273 to −0.088 N·m/kg; knee to support moment ratio, −10.7% to −2.2%; hip to support moment ratio, 3.2% to 8.5%). No interlimb difference was found for the HQ group. The LSI of quadriceps strength was significantly associated with the LSI of peak knee extension moment ( R 2 = 0.183), knee to support moment ratio ( R 2 = 0.256), and hip to support moment ratio ( R 2 = 0.233). The mean maximum isokinetic quadriceps strength and peak knee extension moment during squatting on the involved limb of the LQ group were 2.40 ± 0.39 and 0.90 ± 0.16 N·m/kg, respectively. Conclusion: Asymmetrical biomechanics during double-leg squatting was associated with persistent quadriceps weakness after ACLR. The LQ group had reduced knee extensor moment on the involved side during squatting despite loading at approximately half the maximum strength. Clinical Relevance: Quadriceps strengthening exercises, together with interventions to improve neuromuscular control, may reduce asymmetrical biomechanics during double-leg squatting.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 10
    In: Sports Biomechanics, Informa UK Limited
    Type of Medium: Online Resource
    ISSN: 1476-3141 , 1752-6116
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2098824-2
    SSG: 31
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