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  • 1
    Online Resource
    Online Resource
    University of Texas Press ; 2006
    In:  Texas Studies in Literature and Language Vol. 48, No. 3 ( 2006), p. 250-272
    In: Texas Studies in Literature and Language, University of Texas Press, Vol. 48, No. 3 ( 2006), p. 250-272
    Type of Medium: Online Resource
    ISSN: 1534-7303
    Language: English
    Publisher: University of Texas Press
    Publication Date: 2006
    detail.hit.zdb_id: 2051594-7
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  • 2
    Online Resource
    Online Resource
    Regional Euro-Asian Biological Invasions Centre Oy (REABIC) ; 2022
    In:  Aquatic Invasions Vol. 17, No. 3 ( 2022), p. 253-273
    In: Aquatic Invasions, Regional Euro-Asian Biological Invasions Centre Oy (REABIC), Vol. 17, No. 3 ( 2022), p. 253-273
    Type of Medium: Online Resource
    ISSN: 1818-5487
    URL: Issue
    Language: Unknown
    Publisher: Regional Euro-Asian Biological Invasions Centre Oy (REABIC)
    Publication Date: 2022
    detail.hit.zdb_id: 2381496-2
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  • 3
    In: Journal of Endourology and Minimally Invasive Surgery, Endourology Foundation, Vol. 10, No. 1 ( 2022-7-10), p. 25-32
    Abstract: Introduction: Anatomical features of the lower pole calyces plays an important role in the treatment of urolithiasis. The optimal treatment options for lower pole stones with a diameter below 2 cm are controversially discussed. Extracorporeal shock wave lithotripsy (SWL) is non-invasive, but is hampered by low stone-free rates and a significant retreatment rate in patients with unfavourable factors for lithotripsy. Retrograde intrarenal surgery (RIRS) has been demonstrated to have high stone-free rates since the development of modern flexible endoscopes. But the long operative time in the case of a large stone burden, unfavourable anatomy and considerable costs for consumables represent limiting factors for this technique. With the miniaturization of percutaneous approach and decreasing the morbidity, minimally invasive percutaneous nephrolithotomy (miniPCNL) is a promising method for treatment of lower pole stones in one stage procedure. The objective of this study is to investigate the efficacy and safety of mini-PCNL for the treatment of lower pole stones 1-2 cm. Material and methods: The medical records of 54 patients with lower pole kidney stones 1-2 cm, treated at the Clinic of Endurology and SWL, Military Medical Academy, Sofia between January 2020 to January 2022, were retrospectively reviewed. All patients underwent mini-PCNL under spinal anesthesia in prone position with fluoroscopic guidance through 18 Fr sheath using semirigid nephroscope and Ho:YAG laser for lithotripsy. Stone-free rate was defined as absence of residual fragments ≥2 mm. Data on patients’ preoperative characterstics, stone-free rates, operating times, intra- and postoperative complications were analyzed. Results: Patients mean age was 54,68±11,99 years. Mean stone surface was 169,02±57,40mm2 and mean CT stone density was 1112,26±250,47 HU. Stone-free rate after single procedure was 96,3 % (52 patients). 14,8% of patients had preoperative urinary tract infection. Mean operative time was 27,46±12,40 min and mean hospital stay - 2,5±1,17 days. The mean Hgb drop was 11.9±15.6 g/l. Lower pole puncture was performed in all patients. Two tracts were required in 1 (1,9 %) patient. One patient had intraoperative haemorrhage at the end of the procedure. Postoperative complications were observed in 2 (3,8 %) patients: postoperative fever t 〉 38.5o C in 1 patient (1,9%) and postoperative AV-fistula in 1 (1,9%) patient, who needed hemotransfusion and selective embolization. 2 patients required auxiliary procedures: 1 patient needed stent JJ and 1 underwent ureteroscopy for fragments in ureter. Conclusion: Various factors are important for management of lower pole kidney stones and should be taken into consideration, when choosing the optimal treatment modality. The results from this study suggest that mini-PCNL is an effective and safe procedure with high stone free rates and low complication rates in patients with lower pole kidney stones unfavourable for SWL and RIRS. Key words: minimally invasive nephrolithotomy, lower pole kidney, urolithiasis
    Type of Medium: Online Resource
    ISSN: 1314-846X , 2815-3235
    Language: Unknown
    Publisher: Endourology Foundation
    Publication Date: 2022
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  • 4
    In: Journal of Endourology and Minimally Invasive Surgery, Endourology Foundation, Vol. 10, No. 1 ( 2022-7-10), p. 33-38
    Abstract: Introduction and objective: Acute renal colic due to ureteral calculi is a common urological emergency that can be managed conservatively, by providing renal drainage and medical management of the pain syndrome followed by planned treatment, or by emergency surgery. With the onset of the COVID-19 pandemic leading to the temporary suspension of elective surgical activity, emergency ureteroscopy has become a valuable modality for the treatment of acute renal obstruction. The objective of this study is to evaluate the efficacy and safety of emergency ureteroscopy as first-line treatment for patients with acute renal obstruction due to ureteral stones during the COVID-19 pandemic. Material and methods: A prospectively collected database of 120 patients with acute renal obstruction due to ureteral stone who underwent emergency ureteroscopy within 24 hours from hospitalization between March 2020 and December 2021, was reviewed. Data on patients’ preoperative characteristics, stone-free rates and complication rates was analyzed. Results: Patients’ mean age was 51.4±15.2 years. Male-to-female ratio was 73.3%/26.7%. Mean preoperative serum creatinine values were 120.1±64.1 umol/l. 33 patients (2.5%) had a solitary functioning kidney. Stone location was proximal ureter in 3 patients (27.5%), mid-ureter – in 12 (10%), distal ureter – in 73 (60.8%), distal and proximal ureter – in 2 cases (1.6%). Mean stone size was 8.1±3.3 mm. Stone-free rate after a single procedure was 95% and mean operative time – 25.1±11.5 min. Postoperative drainage was stent JJ in 34 (28.3%) and ureteral catheter for 12h – in 22 (18.3%) patients. 21 patients (17.5%) had a narrow ureter, necessitating the use of smaller caliber ureteroscope (6 Fr). In 2 patients (1.7%) the ureter could not be accessed and a stent JJ was inserted. Intraoperative complications were present in 5 cases – 1 ureteral perforation (0.8%) and 4 cases of upward stone migration (3.3%). Postoperative complications were fever in 2 patients (1.7%) and postoperative renal colic pain - in 7 (5.8%). Conclusions: The results of this prospective study suggest that emergency ureteroscopy is a safe and effective first-line treatment for acute renal obstruction due to ureteral stones. It offers a one-stage management, without the potential complications of obstruction and loss of renal function due to delayed treatment during the COVID-19 pandemic. Key words: Ureterorenoscopy, Ureteral obstruction, Ureteral stone, Covid-19
    Type of Medium: Online Resource
    ISSN: 1314-846X , 2815-3235
    Language: Unknown
    Publisher: Endourology Foundation
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2013
    In:  Transplantation Vol. 95, No. 5 ( 2013-03-15), p. 694-700
    In: Transplantation, Ovid Technologies (Wolters Kluwer Health), Vol. 95, No. 5 ( 2013-03-15), p. 694-700
    Type of Medium: Online Resource
    ISSN: 0041-1337
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2013
    detail.hit.zdb_id: 2035395-9
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  • 6
    Online Resource
    Online Resource
    Prof. Marin Drinov Publishing House of BAS (Bulgarian Academy of Sciences) ; 2023
    In:  Proceedings of the Bulgarian Academy of Sciences Vol. 76, No. 3 ( 2023-03-27), p. 394-406
    In: Proceedings of the Bulgarian Academy of Sciences, Prof. Marin Drinov Publishing House of BAS (Bulgarian Academy of Sciences), Vol. 76, No. 3 ( 2023-03-27), p. 394-406
    Abstract: We investigate the impact of bacterial (Chlamydia trachomatis, Ureaplasma urealyticum/parvum, Mycomplasma hominis/genitalium, Gardnerella vaginalis) and viral (HSV1/2, EBV, CMV, VZV, HHV6/HHV7, HHV8) pathogens, as a potential cause of reproductive failure in women by analysis of menstrual blood. We analyzed DNA extracted from 48 probands selected on the basis of history of infertility. DNA extraction, Real-time qPCR, gel electrophoresis were applied. In 64.6% of all tested menstrual blood samples of infertile women bacterial and/or viral pathogens were detected. In 41.4% of all tested samples we found bacterial, while in 37.5% viral pathogens. Ureaplasma parvum and Gardnerella vaginalis were detected in 58.3% and 54.2%, respectively, of the positive for bacterial pathogens samples. EBV, HHV7 and HHV6 were detected in 38.9%, 55.6%, and, respectively, 11.1% of the positive for viral pathogens samples. Bacterial and viral co-infection was found in 22.6% of all patients. Chlamydia trachomatis, Mycomplasma hominis/genitalium, Ureaplasma urealyticum, HSV1, HSV2, CMV, VZV and HHV8 were not detected in the menstrual blood samples. Our study offers new approach for diagnostics of infections in the upper female genital tract by analysis of menstrual blood. The opportunity to detect asymptomatic bacterial and viral infections in female endometrium contributes to reveal the cause for sterility. Our work contributes to clarify the infectious etiology of reproductive failure which is of a great importance for individualized therapy.
    Type of Medium: Online Resource
    ISSN: 2367-5535 , 1310-1331
    Language: Unknown
    Publisher: Prof. Marin Drinov Publishing House of BAS (Bulgarian Academy of Sciences)
    Publication Date: 2023
    detail.hit.zdb_id: 2435977-4
    SSG: 11
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  • 7
    In: Neurology - Neuroimmunology Neuroinflammation, Ovid Technologies (Wolters Kluwer Health), Vol. 5, No. 3 ( 2018-05), p. e451-
    Abstract: To study the B-cell content, organization, and existence of distinct B-cell subpopulations in relation to the expression of type 1 interferon signature related genes in dermatomyositis (DM). Methods Evaluation of skeletal muscle biopsies from patients with adult DM (aDM) and juvenile DM (jDM) by histology, immunohistochemistry, electron microscopy, and quantitative reverse-transcription PCR. Results We defined 3 aDM subgroups—classic (containing occasional B cells without clusters), B-cell–rich, and follicle-like aDM—further elucidating IM B-lymphocyte maturation and immunity. The quantity of B cells and formation of ectopic lymphoid structures in a subset of patients with aDM were associated with a specific profile of cytokines and chemokines involved in lymphoid neogenesis. Levels of type 1 interferon signature related gene expression paralleled B-cell content and architectural organization and link B-cell immunity to the interferon type I signature. Conclusion These data corroborate the important role of B cells in DM, highlighting the direct link between humoral mechanisms as key players in B-cell immunity and the role of type I interferon–related immunity.
    Type of Medium: Online Resource
    ISSN: 2332-7812
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2767740-0
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  • 8
    In: Journal of Endourology and Minimally Invasive Surgery, Endourology Foundation, Vol. 10, No. 1 ( 2022-7-10), p. 39-42
    Abstract: Introduction and objective: The application of ESWL in treatment of ureteral calculi is to achieve kidney desobstruction with minimal pain, aiming to reduce the need of analgesia and hospital stay. In times of Covid-19 pandemic by reducing the hospital stay, patients have less contacts and it is more safe for them from an epidemiological point of view. The objective of our study is to evaluate the efficacy and safety of ESWL as a method of kidney desobstruction caused of ureteral calculi during Covid-19 pandemic. Material and methods: A retrospectively collected database of 77 patients, who underwent ESWL for ureteral stones between February 2020 and January 2022 in the Clinic of Endourology and SWL, Military Medical Academy, Sofia, Bulgaria, was reviewed. Data on patients’ preoperative characteristics, stone-free rates, complications and auxiliary procedures were analyzed. Results: Patients’ mean age was 49.1±12.8 years and male-to-female ratio – 75.3%/24.7%. Mean stone length was 6.5±2 mm and mean stone width was 4.5±1.5 mm. Fifty-two (n=52, 67.5%) of the cases were with stones located in the proximal ureter, in the middle ureter (n=14, 18.2%) and in the distal ureter (n=11, 14.3%). Preoperative drainage with ureteral stent was completed in 13 cases (16.9%). Mean hospital stay was 1.28 days Mean number of SWL hits was 3527±692. Full stone disintegration was observed in 55 patients (71.4%) and partial disintegration was observed in 22 patients (28.6%). Eight (36.4%) of the patients with partial disintegration of the stone needed another ESWL, in 2 (9%) people was performed RIRS afterward and 8 cases (36.4%) required performing an URS at a later stage. Conclusions: The ESWL as a method of treatment in ureteral calculi has good success rate. With the short hospital stay, it is an appropriate method for times of Covid-19 pandemic. However in some cases, invasive endourological operations such as ureteroscopy could not be avoided in order to be achieved full kidney desobstruction. Key words: extracorporeal lithotripsy, ureteral stones, Covid 19
    Type of Medium: Online Resource
    ISSN: 1314-846X , 2815-3235
    Language: Unknown
    Publisher: Endourology Foundation
    Publication Date: 2022
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  • 9
    In: Journal of Endourology and Minimally Invasive Surgery, Endourology Foundation, Vol. 10, No. 2 ( 2022-11-1), p. 43-48
    Abstract: Introduction and objective: Improvements in endoscopic technologies have led to an expansion of flexible ureteroscopy indications in the treatment of renal and ureteral stones. Ureteral access sheath (UAS) was introduced in the clinical practice to facilitate endoscopic access into the upper urinary tract, reduce intrarenal pressure during the procedure and allow the extraction of fragments. The objective of this study is to analyze the impact of UAS on the efficacy and safety of flexible ureteroscopy (fURS) for the treatment of renal stones. Material and methods: a prospectively collected database including 251 consecutive patients treated with fURS between January 2018 and November 2022 was analyzed. Patients were divided into two groups: group 1 – without UAS, 21 patients (8.3%) and group 2 – with UAS, 231 patients (91.7%). UAS was used at the surgeon’s discretion and 3 patients (1.2%) underwent a sheathless procedure due to failure of UAS insertion. Data on patients’ preoperative characteristics and fURS efficacy and safety were compared. Results: There were no statistically significant differences in patients’ preoperative characteristics except for stone size and surface, which were significantly larger in group 2 (9.6±4.1 vs 13.8±5.2 mm; р 〈 0.001 and 68.6±74.2 vs 128.3±109.3 mm2, p=0.002, respectively). Operating time was significantly longer in group 2 (33.6±12.9 vs 42.0±12.9 min, p=0.005). Stone-free rate after a single procedure and at 3rd postoperative month was similar between groups (95.2% vs 87%, p=0.486 and 95.2% vs 88.7%, p=0.709, respectively). The intra- and postoperative complication rates were higher for group 1 (4.8% vs 0.8%, р=0.011 and 14.3% vs 12.1%, p=0.062, respectively). Multivariate regression model identified stone surface (р 〈 0.001), number of stones (p=0.005) and calcium oxalate monohydrate stone composition (р=0.005), but not UAS use (p=0.580), as independent predictors for stone-free rate following fURS. Conclusions: The results of this study suggest that UAS use has no impact on the efficacy of fURS and is not associated with an increased rate of intra- and postoperative complications.
    Type of Medium: Online Resource
    ISSN: 1314-846X , 2815-3235
    Language: Unknown
    Publisher: Endourology Foundation
    Publication Date: 2022
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  • 10
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 40, No. 3 ( 2013), p. 182-189
    Abstract: The detection of antibodies against the human leukocyte antigen (HLA) complex has become indispensable in every clinical practice. The development of solid-phase assays like the Luminex allows the standardized measurement of anti-HLA antibodies (HLAab) with high sensitivity, albeit the relevance for some clinical settings remains a matter of debate. In this review we aim to describe the principle of Luminex-based antibody detection, including two modifications that allow identifying solely complement-activating antibodies. We then describe three applications for Luminex: i) detection of HLAab preceding solid-organ transplantation and monitoring of donor-specific antibodies posttransplant as a risk factor for antibody-mediated rejection; ii) presence of HLAab in recipients as a risk for graft failure in hematopoietic stem cell transplantation, especially in haploidentical or mismatched transplantations; iii) role of HLAab in blood transfusion including refractory thrombocytopenia and selection of suitable platelet donors, transfusion-related lung injury after plasma transfusion, and immunization against HLA after red blood cell transfusion despite leukodepletion. Although the Luminex platform constitutes a potent technology for HLA antibody detection, some drawbacks require the well-educated analysis and interpretation of data in critical cases. In addition, Luminex has become an important tool to identify clinically relevant antibodies.
    Type of Medium: Online Resource
    ISSN: 1660-3796 , 1660-3818
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 2100533-3
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