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  • 1
    In: Acta Radiologica, SAGE Publications, Vol. 52, No. 10 ( 2011-12), p. 1147-1154
    Kurzfassung: The apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can quantify alterations in water diffusivity resulting from microscopic structural changes from amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Purpose To investigate the ADC value for aMCI and AD using Brain Search (BS) software based on anatomical volumes of interest (AVOI). Material and Methods In total, 174 aged people were screened, and 25 patients with AD, 26 patients with aMCI, and 18 normal controls (NCs) were recruited. DWI was performed at 1.5 T with a fluid-attenuated inversion recovery (FLAIR), and the independent ADC mapping was generated after imaging acquisition. Ninety regional parcellations were adopted in a Brain Search (BS) based on the automated anatomic labeling atlas. The gray scale intensities (water diffusivity) from the collected ADC mappings were analyzed with BS. The mean value of each anatomical brain region was compared among aMCI, AD, and NC. The statistically significant ( P 〈 0.05) group differences are displayed in color. Results During the pathological process of AD, the changes of water diffusivity appeared first in the left hippocampus, then gradually progressed to the bilateral sides and eventually displayed right lateralization. The ADC values from aMCI were obviously elevated compared to the values from the NC group in the left limbic cortex. Between the AD and NC groups, the significantly different brain areas included the bilateral hippocampus, the Cingulum_Mid, the ParaHippocampal_R, and the Temporal and Frontal lobes. There was a negative correlation between the ADC values and the scores from MMSE, MoCA, the Digit test, Raven's IQ, and WAIS IQ. Additionally, the ADC values were positively correlated with the scores from CDR, ADL, and ADAS-Cog. Conclusion The water diffusivity for aMCI and AD displays asymmetric anatomical lateralization. The water diffusivity alterations can be analyzed and visualized with our newly designed analytic imaging software, BS, which can be used as a good reference for examining and diagnosing aMCI and AD patients.
    Materialart: Online-Ressource
    ISSN: 0284-1851 , 1600-0455
    RVK:
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2011
    ZDB Id: 2024579-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-01-11)
    Kurzfassung: The effect of mesenchymal stem cell (MSCs)-based therapy on treating acute myocardial infarction (MI) is limited due to poor engraftment and limited regenerative potential. Here we engineered MSCs with integrin-linked kinase (ILK), a pleiotropic protein critically regulating cell survival, proliferation, differentiation and angiogenesis. We firstly combined ferumoxytol with poly-L-lysine (PLL) and found this combination promisingly enabled MRI visualization of MSCs in vitro and in vivo with good safety. We provided visually direct evidence that intracoronary ILK-MSCs had substantially enhanced homing capacity to infarct myocardium in porcine following cardiac catheterization induced MI. Intracoronary transplantation of allogeneic ILK-MSCs, but not vector-MSCs, significantly enhanced global left ventricular ejection fraction (LVEF) by 7.8% compared with baseline, by 10.3% compared with vehicles and inhibited myocardial remodeling compared with vehicles at 15-day follow-up. Compared with vector-MSCs, ILK-MSCs significantly improved regional LV contractile function, reduced scar size, fibrosis, cell apoptosis and increased regional myocardial perfusion and cell proliferation. This preclinical study indicates that ILK-engineered MSCs might promote the clinical translation of MSC-based therapy in post-MI patients and provides evidence that ferumoxytol labeling of cells combined with PLL is feasible in in vivo cell tracking.
    Materialart: Online-Ressource
    ISSN: 2045-2322
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2016
    ZDB Id: 2615211-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 50, No. D1 ( 2022-01-07), p. D27-D38
    Kurzfassung: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global research in both academia and industry. With the explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up and updating its core database resources through big data archive, curation, integration and analysis. In the past year, efforts have been made to synthesize the growing data and knowledge, particularly in single-cell omics and precision medicine research, and a series of resources have been newly developed, updated and enhanced. Moreover, CNCB-NGDC has continued to daily update SARS-CoV-2 genome sequences, variants, haplotypes and literature. Particularly, OpenLB, an open library of bioscience, has been established by providing easy and open access to a substantial number of abstract texts from PubMed, bioRxiv and medRxiv. In addition, Database Commons is significantly updated by cataloguing a full list of global databases, and BLAST tools are newly deployed to provide online sequence search services. All these resources along with their services are publicly accessible at https://ngdc.cncb.ac.cn.
    Materialart: Online-Ressource
    ISSN: 0305-1048 , 1362-4962
    RVK:
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2022
    ZDB Id: 1472175-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 49, No. D1 ( 2021-01-08), p. D18-D28
    Kurzfassung: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a suite of database resources to support worldwide research activities in both academia and industry. With the explosive growth of multi-omics data, CNCB-NGDC is continually expanding, updating and enriching its core database resources through big data deposition, integration and translation. In the past year, considerable efforts have been devoted to 2019nCoVR, a newly established resource providing a global landscape of SARS-CoV-2 genomic sequences, variants, and haplotypes, as well as Aging Atlas, BrainBase, GTDB (Glycosyltransferases Database), LncExpDB, and TransCirc (Translation potential for circular RNAs). Meanwhile, a series of resources have been updated and improved, including BioProject, BioSample, GWH (Genome Warehouse), GVM (Genome Variation Map), GEN (Gene Expression Nebulas) as well as several biodiversity and plant resources. Particularly, BIG Search, a scalable, one-stop, cross-database search engine, has been significantly updated by providing easy access to a large number of internal and external biological resources from CNCB-NGDC, our partners, EBI and NCBI. All of these resources along with their services are publicly accessible at https://bigd.big.ac.cn.
    Materialart: Online-Ressource
    ISSN: 0305-1048 , 1362-4962
    RVK:
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2021
    ZDB Id: 1472175-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 51, No. D1 ( 2023-01-06), p. D18-D28
    Kurzfassung: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global academic and industrial communities. With the explosive accumulation of multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands and updates core database resources by big data archive, integrative analysis and value-added curation. In the past year, efforts have been devoted to integrating multiple omics data, synthesizing the growing knowledge, developing new resources and upgrading a set of major resources. Particularly, several database resources are newly developed for infectious diseases and microbiology (MPoxVR, KGCoV, ProPan), cancer-trait association (ASCancer Atlas, TWAS Atlas, Brain Catalog, CCAS) as well as tropical plants (TCOD). Importantly, given the global health threat caused by monkeypox virus and SARS-CoV-2, CNCB-NGDC has newly constructed the monkeypox virus resource, along with frequent updates of SARS-CoV-2 genome sequences, variants as well as haplotypes. All the resources and services are publicly accessible at https://ngdc.cncb.ac.cn.
    Materialart: Online-Ressource
    ISSN: 0305-1048 , 1362-4962
    RVK:
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2023
    ZDB Id: 1472175-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    In: Clinical & Experimental Metastasis, Springer Science and Business Media LLC, Vol. 40, No. 4 ( 2023-08), p. 255-287
    Materialart: Online-Ressource
    ISSN: 0262-0898 , 1573-7276
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2023
    ZDB Id: 1496876-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 48, No. 6 ( 2018-12), p. 1518-1528
    Kurzfassung: Accurate glioma grading plays an important role in the clinical management of patients and is also the basis of molecular stratification nowadays. Purpose/Hypothesis To verify the superiority of radiomics features extracted from multiparametric MRI to glioma grading and evaluate the grading potential of different MRI sequences or parametric maps. Study Type Retrospective; radiomics. Population A total of 153 patients including 42, 33, and 78 patients with Grades II, III, and IV gliomas, respectively. Field Strength/Sequence 3.0T MRI/T 1 ‐weighted images before and after contrast‐enhanced, T 2 ‐weighted, multi‐b‐value diffusion‐weighted and 3D arterial spin labeling images. Assessment After multiparametric MRI preprocessing, high‐throughput features were derived from patients' volumes of interests (VOIs). The support vector machine‐based recursive feature elimination was adopted to find the optimal features for low‐grade glioma (LGG) vs. high‐grade glioma (HGG), and Grade III vs. IV glioma classification tasks. Then support vector machine (SVM) classifiers were established using the optimal features. The accuracy and area under the curve (AUC) was used to assess the grading efficiency. Statistical Tests Student's t‐ test or a chi‐square test were applied on different clinical characteristics to confirm whether intergroup significant differences exist. Results Patients' ages between LGG and HGG groups were significantly different ( P   〈  0.01). For each patient, 420 texture and 90 histogram parameters were derived from 10 VOIs of multiparametric MRI. SVM models were established using 30 and 28 optimal features for classifying LGGs from HGGs and grades III from IV, respectively. The accuracies/AUCs were 96.8%/0.987 for classifying LGGs from HGGs, and 98.1%/0.992 for classifying grades III from IV, which were more promising than using histogram parameters or using the single sequence MRI. Data Conclusion Texture features were more effective for noninvasively grading gliomas than histogram parameters. The combined application of multiparametric MRI provided a higher grading efficiency. The proposed radiomic strategy could facilitate clinical decision‐making for patients with varied glioma grades. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1518–1528
    Materialart: Online-Ressource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 1497154-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: Cancer Immunology, Immunotherapy, Springer Science and Business Media LLC, Vol. 72, No. 7 ( 2023-07), p. 1957-1969
    Materialart: Online-Ressource
    ISSN: 0340-7004 , 1432-0851
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2023
    ZDB Id: 1458489-X
    ZDB Id: 195342-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    American Chemical Society (ACS) ; 2020
    In:  ACS Photonics Vol. 7, No. 8 ( 2020-08-19), p. 2132-2138
    In: ACS Photonics, American Chemical Society (ACS), Vol. 7, No. 8 ( 2020-08-19), p. 2132-2138
    Materialart: Online-Ressource
    ISSN: 2330-4022 , 2330-4022
    Sprache: Englisch
    Verlag: American Chemical Society (ACS)
    Publikationsdatum: 2020
    ZDB Id: 2745489-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 72, No. 1 ( 2023), p. 013702-
    Kurzfassung: Hydrogen maser uses the transition frequency of hydrogen atom at hyperfine energy level of ground state to realize precise timing. It has excellent frequency stability, especially in medium- and short-term, and low frequency drift. It has been used as high-precision frequency standard in engineering fields such as time keeping, navigation, and very long baseline interferometry. Clock transition of hydrogen maser is the transition between states of 〈inline-formula〉〈tex-math id="Z-20221227162344"〉\begin{document}$|F = 1, m_{\rm F} = 0\rangle $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162344.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162344.png"/〉〈/alternatives〉〈/inline-formula〉 and 〈inline-formula〉〈tex-math id="Z-20221227162352"〉\begin{document}$|F = 0, m_{\rm F} = 0\rangle $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162352.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162352.png"/〉〈/alternatives〉〈/inline-formula〉. State selection is realized by state selection magnet, through which high energy atoms are converged and low energy atoms are dispersed. In conventional magnet state-selecting system, both atoms of 〈inline-formula〉〈tex-math id="Z-20221227162429"〉\begin{document}$|F = 1, m_{\rm F} = 0\rangle $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162429.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162429.png"/〉〈/alternatives〉〈/inline-formula〉 states, which are required for the maser transition, and useless atoms of 〈inline-formula〉〈tex-math id="Z-20221227162419"〉\begin{document}$|F = 1, m_{\rm F} = 1\rangle $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162419.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162419.png"/〉〈/alternatives〉〈/inline-formula〉 states are focused into storage bulb, which places restrictions on the medium- and long-term frequency stability performance of hydrogen maser. In order to further improve the quality of atomic transition spectral lines and the performance of hydrogen maser, double state-selection beam optical system which is based on the Majorana transition mode is constructed through calculations and simulations. In this work, we use Majorana method to invert atomic states. The magnetic field required for Majorana transition is established by using two coils with reverse current. The two coils are separated by 71 mm, and the coil axes are aligned with the direction of atomic beam. The other two pairs of transverse Helmholtz coils are separated by 22 mm in the center of the state reversal to adjust the zero point of magnetic field, which should coincide with the atomic beam to ensure a complete reversal of atomic polarity. The state reversal region is surrounded by four magnetic shields to reduce the influence of stray magnetic fields. Relationship between selected-state magnetic field gradient and distance of magnetic poles is analyzed by simulation, and trajectories of the atoms with high and low energy under different selected-state magnetic fields are calculated. The utilization and purity of high energy state atoms entering into bulb atoms are obtained. The purity of the selected 〈inline-formula〉〈tex-math id="Z-20221227162405"〉\begin{document}$|F = 1, m_{\rm F} = 0\rangle $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162405.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162405.png"/〉〈/alternatives〉〈/inline-formula〉 state atoms reaches 99% and the utilization rate is 58%. This is ideal for engineering applications. It effectively enhances the proportion of 〈inline-formula〉〈tex-math id="Z-20221227162411"〉\begin{document}$|F = 1, m_{\rm F} = 0\rangle $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162411.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="1-20221363_Z-20221227162411.png"/〉〈/alternatives〉〈/inline-formula〉 state atoms entering into the atomic storage bulb and ensures the utilization of atoms. We verify the state-selection beam optical system experimentally. By turning on double state-selection system the maser signal can be enhanced. By adjusting the coil current of the double state-selection system, the maser signal varies with coil current, which verifies the effectiveness of double state-selection system.
    Materialart: Online-Ressource
    ISSN: 1000-3290 , 1000-3290
    Sprache: Unbekannt
    Verlag: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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