In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 153, No. 2 ( 2005-08), p. 249-256
Abstract:
Objective : The clinical use of growth hormone-releasing hormone (GHRH) is limited by its short half-life. Polyethylene glycol-conjugated GHRH (PEG-GHRH) was developed to provide increased stability compared with the currently available GHRH(1–29). This study aimed to evaluate the safety, tolerability and pharmacodynamics of PEG-GHRH. Design : PEG-GHRH was administered by subcutaneous injection to young healthy men ( n = 12) and elderly men and women (aged 〉 60 years; n = 20). Results : In both groups, administration of PEG-GHRH generated a clear increase in circulating GH compared with placebo. Following single-dose (0.25, 0.5, 2 or 4 mg) administration to young subjects, the effect persisted for 12 h, but a sustained increase was observed on repeated administration to the elderly. Serum insulin-like growth factor-I also increased in response to PEG-GHRH treatment. Injection-site reactions were more frequent with PEG-GHRH compared with placebo, but these were mild and transient; other adverse events were similar to those observed after placebo. Some impairment of glucose tolerance was observed in the elderly following repeated administration of PEG-GHRH. Antibodies to GHRH were not observed. Conclusions : PEG-GHRH offers the possibility of less frequent dosing compared with GHRH. This possibility deserves further clinical testing.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2005
detail.hit.zdb_id:
1485160-X
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