In:
Macromolecular Bioscience, Wiley, Vol. 18, No. 7 ( 2018-07)
Abstract:
In vascular tissue engineering, great attention is paid to the immobilization of biomolecules onto synthetic grafts to increase bio‐ and hemocompatibility—two critical milestones in the field. The surface modification field of poly(ethylene terephthalate) (PET), a well‐known vascular‐graft material, is matured and oversaturated. Nevertheless, most developed methods are laborious multistep procedures generally accompanied by coating instability or toxicity issues. Herein, a straightforward surface modification procedure is presented engineered to simultaneously promote surface endothelialization and anticoagulation properties via the covalent immobilization of gelatin through a photoactivated azide derivative. A complete physicochemical characterization and biological study including cytotoxicity and endotoxin testing are performed. In addition, biocompatibility toward small (diameter ≤ 6 mm) and/or large caliber (diameter ≥ 6 mm) vessels is assessed by micro‐ and macrovascular endothelial cell assays. Superior bio‐ and hemocompatibility properties are seen for the gelatin‐covalently modified PET surfaces compared to the conventional surface‐modification procedures based on physisorption.
Type of Medium:
Online Resource
ISSN:
1616-5187
,
1616-5195
DOI:
10.1002/mabi.201800125
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2039130-4
SSG:
12
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