In:
Tạp chí Nghiên cứu Y học, Hanoi Medical University, Vol. 161, No. 12E11 ( 2022-12-28), p. 117-124
Abstract:
To evaluate the immunostimulatory activity of Efcovida powder, we induced immunosuppression in Swiss mice by cyclophosphamide (CP). Efcovida powder at two doses of 60 mg/kg b.w and 120 mg/kg b.w were administered orally for seven consecutive days to animals. CP (200 mg/kg i.p.) was injected on the 4th day. The result showed that Efcovida powder at the dose of 60 mg/kg b.w only posed an immunostimulating potency in the cyclophosphamide-induced immunosuppression model while Efcovida powder at the dose of 120 mg/kg b.w significantly ameliorated the effects of CP on delayed-type hypersensitivity (DTH) response, leukocyte quantity, relative thymus weight, serum IL-4, IL-6 concentration, and micro-histological images of spleen and thymus. This suggested the potential of Efcovida powder to treat immunosuppression diseases in clinical practice.
Type of Medium:
Online Resource
ISSN:
2354-080X
,
2354-080X
DOI:
10.52852/tcncyh.v161i12E11
DOI:
10.52852/tcncyh.v161i12E11.1172
Language:
Unknown
Publisher:
Hanoi Medical University
Publication Date:
2022
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