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  • 1
    Online Resource
    Online Resource
    Xây dựng kỹ thuật Real-time COLD-PCR có độ nhạy cao để phát hiện đột biến RTA194T kháng thuốc Tenofovir điều trị viêm gan B
    Hanoi Medical University ; 2021
    In:  Tạp chí Nghiên cứu Y học Vol. 143, No. 7 ( 2021-11-01), p. 15-23
    Details
    In: Tạp chí Nghiên cứu Y học, Hanoi Medical University, Vol. 143, No. 7 ( 2021-11-01), p. 15-23
    Abstract: Đột biến rtA194T trên vùng gen mã hóa cho enzym RTase của HBV được chứng minh có liên quan đến tình trạng kháng thuốc Tenofovir disoproxil fumarate (TDF) trong điều trị viêm gan B mạn tính. Trong nghiên cứu này, chúng tôi đã xây dựng thành công kỹ thuật real-time COLD-PCR sử dụng TaqMan LNA probe có với tỷ lệ 0,1% đột biến/thể dại (mt/wt) để phát hiện sớm đột biến rtA194T ở bệnh nhân viêm gan B điều trị TDF. Kỹ thuật sau đó đã được thử nghiệm để phát hiện đột biến rtA194T trên 75 mẫu huyết thanh bệnh nhân viêm gan B mạn tính đã và đang điều trị với TDF, và kết quả là chúng tôi không ghi nhận trường hợp bệnh nhân nào mang đột biến rtA194T. Kết luận lại, kỹ thuật real-time COLD-PCR sử dụng TaqMan LNA probe có độ nhạy cao (0,1% mt/wt) với thời gian thực hiện nhanh trong vòng 3 giờ có tiềm năng ứng dụng trong việc sàng lọc sớm đột biến rtA194T liên quan tới kháng thuốc TDF để tư vấn và theo dõi hiệu quả việc điều trị thuốc TDF cho bệnh nhân viêm gan B trong tương lai.
    Type of Medium: Online Resource
    ISSN: 2354-080X , 2354-080X
    URL: Issue
    URL: Article
    DOI: 10.52852/tcncyh.v143i7
    DOI: 10.52852/tcncyh.v143i7.263
    Language: Unknown
    Publisher: Hanoi Medical University
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Feasibility, acceptability, and bacterial recovery for community-based sample collection to estimate antibiotic resistance in commensal gut and upper respiratory tract bacteria
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-12-29)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-12-29)
    Abstract: Vietnam has high rates of antibiotic use and resistance. Measuring resistance in commensal bacteria could provide an objective indicator for evaluating the impact of interventions to reduce antibiotic use and resistance. This study aimed to evaluate the feasibility, acceptability, and bacterial recovery for different sampling strategies. We conducted a cross-sectional mixed methods study in a rural community in Ha Nam Province, northern Vietnam, and collected structured interviews, samples, and in-depth interviews from households. Out of 389 households invited, 324 participated (83%), representing 1502 individuals. Samples were collected from these individuals (1498 stool, 1002 self-administered nasal swabs, and 496 HW-administered nasopharyngeal swabs). Pneumococci were recovered from 11.1% (128/1149) of the total population and 26.2% (48/183) of those under 5-years. Recovery was higher for health-worker (HW)-administered swabs (13.7%, 48/350) than self-administered swabs (10.0%, 80/799) (OR 2.06, 95% CI 1.07–3.96). Cost per swab was cheaper for self-administered ($7.26) than HW-administered ($8.63) swabs, but the overall cost for 100 positive samples was higher ($7260 and $6300 respectively). Qualitative interviews revealed that HW-administered nasopharyngeal swabs took longer to collect, caused more discomfort, and were more difficult to take from children. Factors affecting participation included sense of contribution, perceived trade-offs between benefits and effort, and peer influence. Reluctance was related to stool sampling and negative perceptions of research. This study provides important evidence for planning community-based carriage studies, including cost, logistics, and acceptability. Self-administered swabs had lower recovery, and though cheaper and quicker, this would translate to higher costs for large population-based studies. Recovery might be improved by swab-type, transport medium, and better cold-chain to lab.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-27084-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 3
    Online Resource
    Online Resource
    Khảo sát nồng độ microalbumin và tổn thương võng mạc ở bệnh nhân đái tháo đường typ 2 mới phát hiện
    Vietnam Association of Diabetes and Endocrinology ; 2021
    In:  Vietnam Journal of Diabetes and Endocrinology , No. 41 ( 2021-01-06), p. 59-64
    Details
    In: Vietnam Journal of Diabetes and Endocrinology, Vietnam Association of Diabetes and Endocrinology, , No. 41 ( 2021-01-06), p. 59-64
    Abstract: Mục tiêu: 1. Khảo sát nồng độ microalbumin và tổn thương võng mạc ở bệnh nhân đái tháo đường typ 2 mới phát hiện tại Bệnh viện Đại học Y Hà Nội. 2. Nhận xét một số yếu tố liên quan đến nồng độ microalbumin và tổn thương võng mạc ở bệnh nhân đái tháo đường typ 2 mới phát hiện. Đối tượng nghiên cứu: 103 bệnh nhân mới phát hiện lần đầu đái tháo đường typ 2 tại Bệnh viện Đại học Y Hà Nội từ tháng 11 năm 2019 đến tháng 8 năm 2020, được làm xét nghiệm microalbumin niệu và khám đáy mắt. Phương pháp: Mô tả cắt ngang. Kết quả và kết luận: Tỷ lệ bệnh nhân cóalbumin niệu và tổn thương võng mạc khi mới phát hiện đái tháo đường typ 2 lần lượt là 33.98%, 3.9%. Tăng huyết áp có liên quan đến nồng độ microalbumin niệu; tuổi, huyết áp, cholesterol toàn phần, LDL-c có liên quan đến tổn thương võng mạc mắt ở nhóm bệnh nhân nghiên cứu, sự liên quan có ý nghĩa thống kê với p 〈 0.05.
    Type of Medium: Online Resource
    ISSN: 1859-4727
    URL: Issue
    URL: Article
    DOI: 10.47122/vjde.2020.41
    DOI: 10.47122/vjde.2020.41.9
    Language: Unknown
    Publisher: Vietnam Association of Diabetes and Endocrinology
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    Một số yếu tố tiên lượng nặng ở bệnh nhân đái tháo đường typ 2 mắc covid-19
    Hanoi Medical University ; 2022
    In:  Tạp chí Nghiên cứu Y học Vol. 159, No. 11 ( 2022-12-07), p. 195-203
    Details
    In: Tạp chí Nghiên cứu Y học, Hanoi Medical University, Vol. 159, No. 11 ( 2022-12-07), p. 195-203
    Abstract: Mục tiêu nghiên cứu nhằm khảo sát một số yếu tố tiên lượng nặng và tử vong ở bệnh nhân đái tháo đường typ 2 mắc COVID-19 tại Bệnh viện điều trị người bệnh COVID-19. Nghiên cứu tiến hành trên 241 bệnh nhân đái tháo đường typ 2 mắc covid  từ tháng 11/2021 đến tháng 3/2022. Nghiên cứu mô tả cắt ngang. Trong 241 bệnh nhân đái tháo đường typ 2, có 24,1% bệnh nhân tử vong. Tỷ lệ tử vong của nhóm đái tháo đường cao hơn nhóm không đái tháo đường, sự khác biệt có ý nghĩa thống kê. Nhóm bệnh nhân nặng và nguy kịch, tử vong có glucose máu, HbA1c, bạch cầu trung tính, ferritin, creatinin máu, D-dimer, Crp-hs, điểm SI X-quang ngực, nhịp thở cao hơn nhóm nhẹ và trung bình. Nhóm nặng, nguy kịch, tử vong có chỉ số SpO2 và bạch cầu lympho thấp hơn. Nhóm nặng và nguy kịch, tử vong cần hỗ trợ liệu pháp oxy liều cao hơn, tỉ lệ cần kiểm soát đường huyết bằng bơm tiêm điện cao hơn nhóm tiêm vaccin có tỷ lệ bệnh nhân nặng và nguy kịch thấp hơn nhóm không tiêm.
    Type of Medium: Online Resource
    ISSN: 2354-080X , 2354-080X
    URL: Issue
    URL: Article
    DOI: 10.52852/tcncyh.v159i11
    DOI: 10.52852/tcncyh.v159i11.1294
    Language: Unknown
    Publisher: Hanoi Medical University
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Data_Sheet_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Plant Science Vol. 12 ( 2021-11-2)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 12 ( 2021-11-2)
    Abstract: Alpha-1,6-mannosyl-glycoprotein 2-β- N -acetylglucosaminyltransferase [EC 2.4.1.143, N -acetylglucosaminyltransferase II (GnTII)] catalyzes the transfer of N-acetylglucosamine (GlcNAc) residue from the nucleotide sugar donor UDP-GlcNAc to the α1,6-mannose residue of the di-antennary N-glycan acceptor GlcNAc(Xyl)Man 3 (Fuc)GlcNAc 2 in the Golgi apparatus. Although the formation of the GlcNAc 2 (Xyl)Man 3 (Fuc)GlcNAc 2 N-glycan is known to be associated with GnTII activity in Arabidopsis thaliana , its physiological significance is still not fully understood in plants. To address the physiological importance of the GlcNAc 2 (Xyl)Man 3 (Fuc)GlcNAc 2 N-glycan, we examined the phenotypic effects of loss-of-function mutations in GnTII in the presence and absence of stress, and responsiveness to phytohormones. Prolonged stress induced by tunicamycin (TM) or sodium chloride (NaCl) treatment increased GnTII expression in wild-type Arabidopsis (ecotype Col-0) but caused severe developmental damage in GnTII loss-of-function mutants ( gnt2-1 and gnt2-2 ). The absence of the 6-arm GlcNAc residue in the N-glycans in gnt2-1 facilitated the TM-induced unfolded protein response, accelerated dark-induced leaf senescence, and reduced cytokinin signaling, as well as susceptibility to cytokinin-induced root growth inhibition. Furthermore, gnt2-1 and gnt2-2 seedlings exhibited enhanced N-1-naphthylphthalamic acid-induced inhibition of tropic growth and development. Thus, GnTII’s promotion of the 6-arm GlcNAc addition to N-glycans is important for plant growth and development under stress conditions, possibly via affecting glycoprotein folding and/or distribution.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2021.761064
    DOI: 10.3389/fpls.2021.761064.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 6
    Online Resource
    Online Resource
    Associations between parent-child relationship, self-esteem, and resilience with life satisfaction and mental wellbeing of adolescents
    Frontiers Media SA ; 2023
    In:  Frontiers in Public Health Vol. 11 ( 2023-1-24)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 11 ( 2023-1-24)
    Abstract: Mental wellbeing and life satisfaction play an important role in the development of adolescents, yet factors potentially influencing these states have not been sufficiently studied, especially in Vietnam. This study aims to fill the research gaps by exploring the associations of the parent-child relationship, self-esteem, and resilience on the mental wellbeing and satisfaction with life of adolescents. Methods A cross-sectional study was conducted from June to July 2020 on 1,023 adolescents from 10 to 18 years old living in Vietnam. To assess the satisfaction with life as well as the mental wellbeing of participants, this study used the Satisfaction with life and The World Health Organization-Five Wellbeing Index scale. Results More than 70% of participants reported having conflicts with their parents (74.6% of those conflicted with their father ad 73.9% of those conflicted with their mother), while 26.3% stated dissatisfaction with life. The mean score of mental wellbeing was 61.5 (SD = 23.0). Higher academic performance, self-esteem, resilience, encounter loneliness and isolation within own family, and having support and sharing from family members had a positive effect on life satisfaction and mental wellbeing. Female participants had higher satisfaction with life score (Coef = 0.77; 95%CI = 0.10; 1.44) but they had a lower mental wellbeing score (Coef = −6.00; 95%CI = −8.57; −3.44) than male participants. High school students had lower both satisfaction with life and mental wellbeing scores than secondary students. Conclusion The results highlight the importance of being aware of the influence that expectations (of higher grades) and bias (toward male children) imposed by parents, teachers, and society on the mental wellbeing of youths, especially in Asian cultures. Strengthening the family bond and encouraging young people to share their feeling is also crucial to enhancing the mental health condition of adolescents.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    DOI: 10.3389/fpubh.2023.1012337
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711781-9
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  • 7
    Online Resource
    Online Resource
    Parent–Child Relationship Quality and Internet Use in a Developing Country: Adolescents’ Perspectives
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychology Vol. 13 ( 2022-2-28)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 13 ( 2022-2-28)
    Abstract: The goal of the study was to explore the relationship between parent–children relationships related to using the internet among kids and potentially associated factors. Materials and Methods A sample of 1.216 Vietnamese students between the ages of 12 and 18 agreed to participate in the cross-sectional online survey. Data collected included socioeconomic characteristics and internet use status of participants, their perceived changes in relationship and communication between parents and children since using the internet, and parental control toward the child’s internet use. An Ordered Logistic Regression was carried out to determine factors associated with parent–children relationship since using the internet. Results The characteristics of the relationship between children and their parents since using the Internet were divided into three levels: deterioration (7.0%), stability (78.2%), and improvement (14.8%). The topics that children most often communicate with their parents include learning, housework, and future directions. Two-way interactive activities, such as supporting parents to use the Internet, have a positive impact on the parent–child relationship. Stubborn parental control, such as establishing rules about contact or allowing Internet access and setting up global positioning system (GPS) to track negatively affecting parent–child relationships. Conclusion Findings indicated that changes in the quality of the parent–child relationship were self-assessed by participants regard to kids’ internet use, especially in the COVID-19 epidemic context. Educational campaigns and programs to raise awareness of parents as to the dangers and negative influences that their children may encounter online, psychology of children’s behaviors and effects of different responding strategies are recommended.
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2022.847278
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2563826-9
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  • 8
    Online Resource
    Online Resource
    Determinants of mental health among youths and adolescents in the digital era: Roles of cyber and traditional bullying, violence, loneliness, and environment factors
    Frontiers Media SA ; 2022
    In:  Frontiers in Public Health Vol. 10 ( 2022-10-25)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-10-25)
    Abstract: Although the pathogenesis of depressive disorders is not fully elucidated, untreated adolescent depression can lead to serious sequelae such as impaired academic performance and social functioning, substance use disorders, poor self-esteem, and increased risk for suicidal ideation and attempts. Literature on adolescent mental health in Vietnam is limited, despite increased international awareness of this critical issue. This study aimed to investigate the prevalence and associations of depressive symptoms in Vietnamese adolescents. Methods A cross-sectional, self-administered survey was conducted in five provinces of Vietnam among adolescents aged 14 to 24 years. In addition to collecting participants' demographics, a structured questionnaire was developed to examine depressive symptoms, suicidal ideation, loneliness, and cyberbullying victimization. Depressive symptoms and loneliness were assessed via the PHQ-9 and UCLA Loneliness Scale, respectively. Two-tailed Chi-squared, Mann-Whitney, and Kruskal-Wallis tests were performed to examine associations between variables. Multivariate Logistic regression models were conducted to examine the associations between prior-defined variables and positive depressive symptoms. Results Among 1,600 respondents, 31.8% of participants reported having mild-moderate or severe depressive symptoms. Participants within the moderate-severe depressive symptom group had significantly lower community cohesion scores than those of participants in normal and mild depressive symptom groups ( p & lt; 0.05). Youths living alone were more likely to have moderate-severe depressive symptoms (OR 2.16; 95% CI: 1.09–4.25). Cyberbullying had significant associations with depressive severity (OR 1.93; 95% CI 1.38–2.70). Conclusion The findings of this study characterize various risk and protective factors for depression in Vietnamese youths and adolescents. The results highlight the importance of raising awareness and increasing access to educational resources for depression and other mental health illnesses. With the rising prevalence of depression, parents, teachers, and community leaders play a vital role in addressing mental health problems in adolescents.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    DOI: 10.3389/fpubh.2022.971487
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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  • 9
    Online Resource
    Online Resource
    Association of Individual and Neighborhood Characteristics to Problematic Internet Use among Youths and Adolescents: Evidence from Vietnam
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 3 ( 2023-01-23), p. 2090-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 3 ( 2023-01-23), p. 2090-
    Abstract: Introduction: This study aimed to determine latent profiles from the Problematic Internet Use Questionnaire Short Form-6 (PIUQ-SF-6) score of Vietnamese youths and adolescents, which supports the diagnosis of problematic internet use among a large sample size. Moreover, it also explored factors that affect each latent profile of the PIUQ-SF-6 score among participants. Methods: A sample of 1477 Vietnamese people, aged 14 to 24, across five provinces participated in the study. Multinomial logistic regression determined factors related to the levels of the Problematic Internet Use Questionnaire Short Form-6 (PIUQ-SF-6) after using latent profile analysis. Results: Participants were divided into three profiles, including those at low, moderate, and high risk of internet addiction. The high-risk latent profile was obtained for 23.1% of adolescents, and the remaining percentages were, respectively, 40.2% and 36.7% of adolescents belonging to the moderate and low-risk groups. Moreover, factors including age, living alone, high Kessler psychological distress scale, excessive time on the internet, living in central cities, and high neighborhood disorder scores were found to be related to moderate- and high-risk internet addiction profiles. Conclusions: Factors analyzed according to individual and social characteristics further explore the reasons underlying increasing internet addiction among Vietnamese youths and inform early interventions.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph20032090
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
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  • 10
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    Online Resource
    Bibliometric Research on Youth Entertainment Activities in Social Media between 2000 and 2021 from Scopus
    EManuscript Technologies ; 2022
    In:  Journal of Scientometric Research Vol. 10, No. 3 ( 2022-01-19), p. 337-347
    Details
    In: Journal of Scientometric Research, EManuscript Technologies, Vol. 10, No. 3 ( 2022-01-19), p. 337-347
    Type of Medium: Online Resource
    ISSN: 2321-6654 , 2320-0057
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.5530/jscires.10.3
    DOI: 10.5530/jscires
    DOI: 10.5530/jscires.10.3.50
    Language: Unknown
    Publisher: EManuscript Technologies
    Publication Date: 2022
    detail.hit.zdb_id: 2694338-4
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