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  • 1
    Online Resource
    Online Resource
    Formulation of Sustained-Release Matrix Tablet of Rotundin Sulfat
    Vietnam National University Journal of Science ; 2019
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 35, No. 1 ( 2019-06-21)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 35, No. 1 ( 2019-06-21)
    Abstract: Sustained-release matrix tablets containing rotundin sulfat are prepared by a wet granulation method. The influence of Metholose 100.000 RS,  4000 SR, Avicel PH101, lactose and tablet compression force on the ability to release rotundin from the tablets has been evaluated. Modde 8.0 software was used in the experiment. The influencing factors were evaluated by software FormRules v2.0 and the optimal formula predicted by the INForm v3.1 was optimized. The selected optimal formulation of rotundin sulfate tablets for a drug release process lasting 8 hours contained Metholose 100.000 RS 120 mg; Avicel PH101 24.0 mg; lactose 34.5 mg; and 8 kP tablet hardness. Keywords Rotundin sulfat, matrix tablet, sustained release, optimizing. References [1] Đỗ Tất Lợi, Những cây thuốc và vị thuốc Việt Nam, NXB Thời Đại (2011), 779. [2] Nguyễn Minh Chính và CS, Nghiên cứu tách chiết rotundin để sản xuất thuốc tiêm rotundin sulfat, Tạp chí Y Dược học Quân sự. 1 (1999) 55-56. [3] Nguyễn Thanh Hải, Bùi Thanh Tùng, Phạm Thị Minh Huệ (2017), Phỏng sinh học trong y dược học – Hướng nghiên cứu cần đẩy mạnh, Tạp chí khoa học ĐHQGHN, Khoa học Y Dược. 33(1) (2017) 1-4. [4] Bộ Y tế, Dược điển Việt Nam V, Nhà xuất bản Y học, 1 (2017), 842-844. [5] M. Levina, A.R. Rajabi-Siaboomi, The influence of excipients on drug release from hydroxypropyl methylcellulose matrices, Journal of Pharmaceutical Sciences. 93(11) (2004) 2746-2754. [6] Nguyễn Minh Chính, Nguyễn Thị Hồng Thắm, Nguyễn Văn Bạch, Tối ưu hóa công thức bào chế viên nén rotundin sulfat giải phóng kéo dài, Tạp chí Y Dược học Quân sự. số CĐ Dược (2016), 61-67. [7] N. Aruna, K.M. Babu, Formulation and evaluation of sustained release matrix tablets containing metformin HCl and Syzygium cumini, International Journal of Pharmaceutical and Biological Archive. 2(3) (2011), 900-905. [8] B.J. Lee, et al, Formulation and release charecteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin, Drug Development and Industrial Pharmacy. 25 (1999) 493-501.[9] A. Nokhochi, J.L. Ford, P. Rowe, et al, The e ffects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropyl methylcellulose 2208, International Journal of Pharmaceutics. 129 (1996), 21-31.  
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4172
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2019
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  • 2
    Online Resource
    Online Resource
    Flos Lonicerae: A Review of Chemical Structures and Biological Activities of Phenolic Derivatives
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 4 ( 2022-12-18)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 4 ( 2022-12-18)
    Abstract: Flos Lonicerae, a widely used Vietnamese medicinal material, is the dried buds or flowers of Lonicera japonica Thunb., and several other species of genus Lonicera such as Lonicera dasystyla Rehd., Lonicera confusa DC., Lonicera cambodiana Pierre ex Danguy, belonging to the family Caprifoliaceae. This material has been used for a long time in traditional medicine for clearing heat, removing toxins, and dispersing wind heat. According to a variety of recent phytochemistry and biological studies that we systematically summarized, Flos Lonicerae contains 129 phenolic derivatives including 48 flavonoids, 13 lignans and neolignans, 55 phenolic acid derivatives, and 13 other phenolic compounds. These phenolic compounds have remarkable biological effects such as antibacterial, antiviral, antioxidant, anti-inflammatory, anti-cancer, hepatoprotective, anti-endotoxin, anti-allergic, anti-diabetic, cardioprotective, anti-allergic activities, etc. In particular, chlorogenic acid, a prominent component with significant biological activities, is utilized as a marker compound to evaluate the quality of Flos Lonicerae in the Vietnamese and Chinese Pharmacopoeia.      
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4429
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 3
    Online Resource
    Online Resource
    Simultaneous Quantification of Acid chlorogenic, Acid caffeic and Rutin in Herba Siegesbeckiae orientalis by HLPC Method
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 39, No. 2 ( 2023-06-20)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 39, No. 2 ( 2023-06-20)
    Abstract: Herba Siegesbeckiae is a medicinal material derived from the aerial part of Siegesbeckia orientalis, which is used to treat various types of pain such as back, knees, bones, joints, and numbness of limbs. This plant contains several phenolic compounds, including chlorogenic acid (1), caffeic acid (2), and rutin (3). They were chosen as marker compounds to develop a quantification method. In this study, a high-performance liquid chromatography (HPLC) method with a DAD detector was used to simultaneously quantify these three compounds (1-3). The Agilent C18 column (250 x 4.6 mm; 5 µm) was used for the separation of the analytes, and the mobile phase consisted of MeCN - 0.1% phosphoric acid in water with gradient elution. The flow rate was 1.0 ml/min, and the detection wavelength was 320 nm for 1 and 2, and 360 nm for 3. The injection volume was 20 µl. The method was validated according to the guidelines of ICH and AOAC on system suitability, specificity, linearity, precision, and accuracy. The established quantification method was applied to determine the content of compounds 1, 2, and 3 in samples of Herba Siegesbeckiae, which were found to be 0.09-0.82 mg/g, 0.02-0.21 mg/g, 0.07-0.52 mg/g, respectively. This quantification method can be used to assess the quality of Herba Siegesbeckiae and related products.
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4522
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Development of an HPLC Method for Simultaneous Quantification of Rosmarinic Acid, Sinensetin in Herba Orthosiphonis spiralis
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 39, No. 2 ( 2023-06-21)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 39, No. 2 ( 2023-06-21)
    Abstract: The purpose of this study was to develop an HPLC method for the simultaneous quantification of rosmarinic acid and sinensetin in Herba Orthosiphonis spiralis. The chromatographic separation was performed on an Ascentis®C8 column (250 × 4.6 mm, 5 µm) using a gradient elution mode with acetonitrile and water containing 0.1% formic acid as mobile phase. The flow rate was maintained at 0.6 mL/min. The injection volume was 10 mL. The column temperature was set at 40 °C. Analytes were detected by a PDA detector at a wavelength of 329 nm. The method was validated for specificity, system suitability, linearity, accuracy, precision, detection limit, and quantitation limit according to ICH and AOAC. The results of validation showed that the method met all the acceptance criteria and was suitable for simultaneous quantification of rosmarinic acid and sinensetin in Herba Orthosiphonis spiralis.
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4505
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Simultaneous Quantification of Kirenol, Daurutoside, and Darutigenol in Siegesbeckia orientalis L. by HLPC-DPA Method
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 2 ( 2022-06-24)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 2 ( 2022-06-24)
    Abstract: Kirenol (1), darutoside (2), and darutigenol (3), which are major active diterpenoids isolated from Herba Siegesbeckiae, are reported for analgesic activity and inflammatory effects. Currently, in Vietnamese Pharmacopoeia V, there is no requirement for the contents of active ingredients in this medicinal plant. In this study, a high-performance liquid chromatography (HPLC) method, which was developed with good repeatability and recovery, was used for simultaneous quantification of 1, 2, and 3 in Herba Siegesbeckiae. This method was successfully applied to quantify 1-3 in samples of Herba Siegesbeckiae collected from different locations. The results showed that the content of compound 1 accounted for 0 – 5.77 mg/g, compound 2 ranged from 0.82 to 5.48 mg/g, and compound 3 ranged from 0.37 to 3.18 mg/g. These results are considered a reference for upgrading the specification and quality control of Herba Siegesbeckiae. Keywords: Herba Siegesbeckiae; kirenol; darutoside; darutigenol; HPLC.    
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4399
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    Preparation of Berberine Chloride Nanoparticles by Ball Milling Method
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 4 ( 2022-12-18)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 4 ( 2022-12-18)
    Abstract: Berberine is a quaternary benzylisoquinoline alkaloid that has been used for the local treatment of gastrointestinal tract diseases. Recently, several pharmacological effects of berberine have been reported, which include anti-hypertension, antitumor, anti-hypercholesterolemia, and neuroprotective effects. However, berberine has exhibited poor aqueous solubility and low oral bioavailability. To overcome these limitations, this study aims to develop and investigate nano berberine. Nano berberine fabricated by ball milling method is a simple process and easily applied in the production scale. The characterization of nano berberine was evaluated, including appearance, particle size, potential zeta, dissolution in vitro in a phosphate buffer media (pH 6.8), differential scanning calorimetry (DSC) analysis, fourier transformed infrared spectroscopy (FTIR), and X-ray diffraction analysis (XRD). Results from this study showed that spray-dried nano berberine powder was almost uniform in size, particle size average of 570.7 nm, and potential zeta of -28.6 mV. The dissolution in vitro study revealed that nano berberine was about 2 times more soluble than raw berberine for 60 minutes. No incompatibility between drug and excipients can be observed through FTIR and DSC analysis. XRD analysis suggested that raw berberine and nano berberine might exist in a crystal form. Thus, findings from this study indicate that the physicochemical properties of spray-dried nano berberine may increase the bioavailability of oral berberine.  
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4437
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Evaluation of Protein Kinase C Inhibition of some Benzofuro[3,2-d]pyrimidine Derivatives
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 39, No. 1 ( 2023-03-25)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 39, No. 1 ( 2023-03-25)
    Abstract: Abstract: Treatment of fungal infections is very difficult because of the limited therapeutic arsenal and the emergence of resistance to the two major antifungal classes: azoles and echinocandins. Consequently, finding new targets and new therapeutic strategies is a priority. The protein kinase Pkc1 of Candida albicans (CaPkc1), one of the key proteins involved in MAPK pathways, is described as a regulator of cell wall integrity during growth, morphogenesis, and response to cell wall stress. Therefore, the discovery of CaPkc1 inhibitory molecules can open up new and promising prospects in the development of new antifungal drugs that inhibit CaPkc1. In this study, we evaluated the CaPkc1 inhibitory activity of three benzofuro[3,2-d]pyrimidine derivatives at three different concentrations of 50 µM, 100 µM, and 150 µM. A concentration of 100 μM was optimal for CaPkc1 inhibitory activity with all three benzofuro[3,2-d]pyrimidine derivatives. Keywords: Benzofuro[3,2-d]pyrimidine, CaPkc1, Candida albicans, antifungal activity.     
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4493
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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  • 8
    Online Resource
    Online Resource
    An Exploration of Interlinkages between International Trades and Green Energy Volatility over Quantiles
    World Scientific Pub Co Pte Ltd ; 2023
    In:  Journal of International Commerce, Economics and Policy
    Details
    In: Journal of International Commerce, Economics and Policy, World Scientific Pub Co Pte Ltd
    Abstract: In this paper, we employ the quantile vector autoregression (QVAR) technique to determine the degree of connectedness between seven variables from 1985 to 2019 for the purpose of examining the relationships between the Trade market and Green energy consumption. Based on our findings, dynamic connectedness, which is 24.18% in the short term and 9% in the long term, is influenced by both long-term and short-term periods. Based on the dynamic net total connectedness of a quantile, a quantile of 50% describes the period’s overall connectedness, which is associated both with highly positive changes (above the 80% quantile) and with highly volatile variables (below the 20% quantile) of export, import, and green energy consumption. In both durations, export and import values turn into a net shock transmitter, and green energy consumption acts like a net shock receiver since the last half of the period. In 2008, uncertain events were correlated with dynamic net pairwise directional connectedness over a quantile, such as the Global Financial crisis, have an influence on the trade market and green energy consumption’s volatility.
    Type of Medium: Online Resource
    ISSN: 1793-9933 , 1793-9941
    URL: Article
    DOI: 10.1142/S1793993323500205
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    Impact of financial constraints on the development of Vietnam’s firms
    Growing Science ; 2020
    In:  Management Science Letters ( 2020), p. 1683-1692
    Details
    In: Management Science Letters, Growing Science, ( 2020), p. 1683-1692
    Type of Medium: Online Resource
    ISSN: 1923-9335 , 1923-9343
    URL: Article
    DOI: 10.5267/j.msl.2020.1.012
    Language: Unknown
    Publisher: Growing Science
    Publication Date: 2020
    detail.hit.zdb_id: 2592009-1
    SSG: 3,2
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  • 10
    Online Resource
    Online Resource
    Effects of water scarcity awareness and climate change belief on recycled water usage willingness: Evidence from New Mexico, United States
    Ministry of Science and Technology, Vietnam (VMOST) ; 2024
    In:  Ministry of Science and Technology, Vietnam Vol. 66, No. 1 ( 2024-4-20), p. 62-75
    Details
    In: Ministry of Science and Technology, Vietnam, Ministry of Science and Technology, Vietnam (VMOST), Vol. 66, No. 1 ( 2024-4-20), p. 62-75
    Abstract: The global water crisis is being exacerbated by climate change, even in the United States. Recycled water is a feasible alternative to alleviate the water shortage, but it is constrained by humans’ perceptions. The current study examines how residents’ water scarcity awareness and climate change belief influence their willingness to use recycled water directly and indirectly. Bayesian Mindsponge Framework (BMF) analytics was employed on a dataset of 1831 residents in Albuquerque, New Mexico, an arid inland region in the US. We discovered that residents’ willingness to use direct recycled potable water is positively affected by their awareness of water scarcity, but the effect is conditional on their belief in the impacts of climate change on the water cycle. Meanwhile, the willingness to use indirect recycled potable water is influenced by water scarcity awareness, and the belief in climate change further enhances this effect. These findings implicate that fighting climate change denialism and informing the public of the water scarcity situation in the region can contribute to the effectiveness and sustainability of long-term water conservation and climate change alleviation efforts.
    Type of Medium: Online Resource
    ISSN: 2734-9748
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.31276/VMOSTJOSSH.66(1)
    DOI: 10.31276/VMOSTJOSSH.vol(number).page
    DOI: 10.31276/VMOSTJOSSH.66(1).62-75
    Language: Unknown
    Publisher: Ministry of Science and Technology, Vietnam (VMOST)
    Publication Date: 2024
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