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  • 1
    Online Resource
    Online Resource
    Vietnam Medical Journal, Vietnam Medical Association ; 2022
    In:  Tạp chí Y học Việt Nam Vol. 517, No. 1 ( 2022-08-21)
    In: Tạp chí Y học Việt Nam, Vietnam Medical Journal, Vietnam Medical Association, Vol. 517, No. 1 ( 2022-08-21)
    Abstract: Mục tiêu: Mô tả đặc điểm lâm sàng, cận lâm sàng và xác định tỷ lệ nhập chăm sóc tích cực, đặt nội khí quản thở máy và tử vong của BN COVID-19 nhập bệnh viện PHCN-ĐTBNN. Đối tượng và phương pháp: Chúng tôi tiến hành nghiên cứu mô tả cắt ngang trên 104 BN. Kết quả và kết luận:  42,3% là nam giới. Tuổi trung bình 61,7 ± 13,7. Các triệu chứng cơ năng thường gặp là sốt (76,9%), mệt mỏi (53,8%). Đa số BN trong nghiên cứu có mạch nhanh, nhịp thở tăng, SpO2 giảm, nhóm tử vong so với nhóm khỏi bệnh có nhịp thở trung vị cao hơn (32 so với 24 lần/phút) và SpO2 thấp hơn (78% so với 91%), (p 〈 0,001). Ure, Creatinine, AST, D-Dimer, Ferritin, CRP của nhóm tử vong cao hơn so với nhóm khỏi bệnh (p 〈 0,05). Nồng độ Natri trung vị ở nhóm tử vong thấp hơn nhóm khỏi bệnh (p=0,008). Tổn thương trên X quang ngực thường gặp dạng mô kẽ, lưới nốt, mờ phế nang và đông đặc phổi. Đa số BN có tổn thương cả 2 bên phổi, chủ yếu tập trung 1/3 ngoài. Hầu hết (98%) có mờ kiểu lan tỏa và không đồng nhất. Hơn 90% tập trung ở 1/3 dưới hai bên phổi. Điểm số X quang Brixia trung vị 8, khoảng tứ phân vị 5-11. Nhóm khỏi bệnh có điểm Brixia trung vị thấp hơn đáng kể (p 〈 0,001) so với nhóm tử vong (7 điểm so với 11 điểm). Tỉ lệ COVID-19 nhẹ và trung bình là 13,4%, nặng 32,7%; nguy kịch 40,4%. 73,1% trường hợp có chỉ định nhập ICU. 84,6% BN cần hỗ trợ hô hấp. 30,7% BN phải chuyển sang thở máy xâm lấn trong quá trình theo dõi. Thời gian nằm viện trung vị là 13 ngày (KTPV 10-17,75 ngày). Tỷ lệ BN đặt nội khí quản thở máy 31,7%. Tỷ lệ tử vong chung là 29,8%.
    Type of Medium: Online Resource
    ISSN: 1859-1868
    Language: Unknown
    Publisher: Vietnam Medical Journal, Vietnam Medical Association
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2019
    In:  Journal of the American College of Cardiology Vol. 73, No. 9 ( 2019-03), p. 1601-
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 73, No. 9 ( 2019-03), p. 1601-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1468327-1
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  • 3
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2023
    In:  The Open Respiratory Medicine Journal Vol. 17, No. 1 ( 2023-04-03)
    In: The Open Respiratory Medicine Journal, Bentham Science Publishers Ltd., Vol. 17, No. 1 ( 2023-04-03)
    Abstract: Coronavirus disease 2019 (COVID-19) may result in a severe acute respiratory syndrome that leads to a worldwide pandemic. Despite the increasing understanding of COVID-19 disease, the mortality rate of hospitalized COVID-19 patients remains high. Objective: To investigate the risk factors related to the mortality of admitted COVID-19 patients during the peak of the epidemic from August 2021 to October 2021 in Vietnam. Methods: This is a prospective cohort study performed at the Hospital for Rehabilitation–Professional diseases. The baseline and demographic data, medical history, clinical examination, the laboratory results were recorded for patients admitted to the hospital with confirmed COVID-19. A radiologist and a pulmonologist will read the chest radiographs on admission and calculate the Brixia scores to classify the severity of lung abnormalities. Patients were followed up until beingrecovered or their death. Comparison of clinical and subclinical characteristics between recovery and death groups to find out risk factors related to the death of COVID-19 patients Results: Among 104 admitted COVID-19 patients, men accounted for 42.3%, average age of 61.7 ± 13.7. The most common symptoms were fever 76.9%, breathlessness 74%, and fatigue 53.8%. The majority (84.6%) of the study population had at least one co-morbidity, including hypertension (53.8%), diabetes (25.9%), gastritis (19.2%), ischemic heart disease (15.4) %), stroke (9.6%) and osteoarthritis (9.6%). The rate of mild and moderate COVID-19 is 13.4%, severe 32.7%, and critical 40.4%. There are 88 inpatients (84.6%) who needed respiratory support. The median hospital stay was 13 days (IQR 10-17.75 days). The rate of intubated patients with mechanical ventilation was 31.7%. The overall mortality rate was 29.8%. Risk factors related to death included Brixia scores 〉 9, Urea 〉 7 mmol/L, Ferrtin 〉 578 ng/ml, Failure to get vaccinated, Age 〉 60 years, and Low Oxygen SpO2 〈 87% (BUFFALO). Conclusion: The main result of the study is the independent risk factors related to the death of admitted COVID-19 patients including Brixia scores 〉 9, Urea 〉 7 mmol/L, Ferrtin 〉 578 ng/ml, Failure to get vaccinated, Age 〉 60 years, and Low Oxygen SpO2 〈 87% ((BUFFALO) which suggests that these COVID-19 patients should be closely followed up.
    Type of Medium: Online Resource
    ISSN: 1874-3064
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    detail.hit.zdb_id: 2395996-4
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  • 4
    Online Resource
    Online Resource
    Elsevier BV ; 2016
    In:  Journal of the American College of Cardiology Vol. 67, No. 13 ( 2016-04), p. 1164-
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 67, No. 13 ( 2016-04), p. 1164-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 1468327-1
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  • 5
    In: The Lancet, Elsevier BV, Vol. 402, No. 10395 ( 2023-07), p. 27-40
    Type of Medium: Online Resource
    ISSN: 0140-6736
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 6
    Online Resource
    Online Resource
    Pham Ngoc Thach University of Medicine ; 2022
    In:  Pham Ngoc Thach Journal of Medicine and Pharmacy , No. 2022 - Volume 1.2 ( 2022-6-1)
    In: Pham Ngoc Thach Journal of Medicine and Pharmacy, Pham Ngoc Thach University of Medicine, , No. 2022 - Volume 1.2 ( 2022-6-1)
    Abstract: Liệu pháp oxy lưu lượng cao qua ống thông mũi (HFNC) đã trở nên phổ biến trong các đơn vị hồi sức tích cực để điều trị bệnh nhân suy hô hấp cấp tính giúp một số bệnh nhân giảm oxy máu nặng để tránh đặt nội khí quản và cải thiện kết cục lâm sàng. Chỉ số ROX có thể giúp theo dõi đáp ứng với điều trị HFNC. Lợi ích của liệu pháp oxy lưu lượng cao qua ống thông mũi cũng được nhận thấy ở bệnh nhân hô hấp mạn tăng CO2 máu. Ngoài ra, HFNC có thể được sử dụng như phương pháp thở oxy dự phòng giảm oxy trong quá trình đặt nội khí quản hoặc kết hợp với thông khí không xâm lấn (NIV). HFNC giúp giảm tỷ lệ đặt lại nội khí quản sau rút nội khí quản. HFNC dung nạp tốt hơn NIV. Đặc biệt, trong suy hô hấp liên quan COVID-19, HFNC cho thấy giảm tỉ lệ đặt nội khí quản, giảm thời gian nằm ICU và giảm biến chứng liên quan thở máy. Chuyên đề này nhằm mục đích tóm tắt dữ liệu hiện có trong các y văn và các hướng dẫn về liệu pháp oxy lưu lượng cao qua ống thông mũi trong thực hành lâm sàng Abstract High - flow nasal cannula (HFNC) therapy has become popular in intensive care units for treatment of acute respiratory failure patients. HFNCcan prevent some patients with severe hypoxemia from intubationand improve clinical outcomes. The ROX index can help tomonitor response to HFNC treatment. The benefit of HFNC has also been seen in patients with chronic hypercapnia. Furthermore, HFNChas also been evaluated as a means to prevent desaturation during intubation or in combination with noninvasive ventilation (NIV). HFNC helps to reduce the rate of re-intubation. HFNC is more tolerance than NIV. Particularly in COVID-19 - associated respiratory failure, HFNC has been shown to reduce intubation rates, ICU stay and ventilator - associated complications. This topic is intended to summarize the available data in the literature and guidelines for HFNC oxygen therapy in clinical practice.
    Type of Medium: Online Resource
    ISSN: 2815-6366 , 2815-6366
    URL: Issue
    Language: Vietnamese
    Publisher: Pham Ngoc Thach University of Medicine
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Pham Ngoc Thach University of Medicine ; 2022
    In:  Pham Ngoc Thach Journal of Medicine and Pharmacy , No. 1 - Volume 1 ( 2022-3-1)
    In: Pham Ngoc Thach Journal of Medicine and Pharmacy, Pham Ngoc Thach University of Medicine, , No. 1 - Volume 1 ( 2022-3-1)
    Abstract: Bệnh COVID-19 do vi rút Corona mới (SARS-CoV-2) gây ra. Khác với SARS-CoV và MERS-CoV về di truyền và dịch tễ học, SARS-CoV-2 là một loại β-coronavirus, xâm nhập qua trung gian vùng liên kết thụ thể (RBD) trong protein S và thụ thể men chuyển angiotensin 2 (ACE2) trên bề mặt của tế bào ký chủ. Bệnh gây ra đại dịch toàn cầu dẫn đến hậu quả nặng nề. Triệu chứng lâm sàng đa dạng trên nhiều cơ quan như hô hấp, tim mạch, tiêu hóa, thần kinh, nội tiết… và có thể dẫn đến suy hô hấp cấp, tử vong. X quang ngực thẳng là phương tiện sẵn có, an toàn và giúp phát hiện sớm cũng như phân mức độ nặng của tổn thương phổi ở bệnh nhân COVID-19. Thang điểm Brixia giúp đánh giá bán định lượng về mức độ nặng và mức độ lan rộng tổn thương phổi ở những bệnh nhân nhập viện với COVID-19. So với các thang điểm khác, Brixia tương đối đơn giản, dễ áp dụng và có thể lặp lại nhiều lần trên lâm sàng. Thang điểm cũng có sự phù hợp cao giữa các bác sĩ quan sát và hữu ích cho dự đoán tỷ lệ tử vong ở bệnh nhân nhập viện do nhiễm SARS-CoV-2. Abstract COVID-19 is caused by the novel coronavirus (SARS-CoV-2). Different from SARS-CoV and MERS-CoV in genetics and epidemiology, SARS-CoV-2 is aβcoronavirus that invades host cells mediated by the receptor-binding region (RBD) in the S protein and the angiotensin-converting enzyme 2 (ACE2). The disease causes a global pandemic that leads to severe consequences. Clinical features are diverse and impactmany systems such as respiratory, cardiovascular, digestive, neurological, endocrinesystemssystems..., it can lead to acute respiratory failure, and even death. Chest X-rayX-rays are available, safe, and useful in early detection and grading the severity of lung injury. The Brixia score provides a se mi-quantitative assessment of the severity and extent of lung injury in hospitalized patients with COVID-19. Compared with other severity scorings, Brixia is quite simple, applicable, and reproducible in clinical practice. Brixia also has a high degree of concordance between observers and is useful for predicting mortality in hospitalized patients with SARS-CoV-2 infection.
    Type of Medium: Online Resource
    ISSN: 2815-6366 , 2815-6366
    URL: Issue
    Language: Vietnamese
    Publisher: Pham Ngoc Thach University of Medicine
    Publication Date: 2022
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  • 8
    In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 71, No. 10 ( 2020-12-17), p. 2679-2687
    Abstract: Little is known about the natural history of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We conducted a prospective study at a quarantine center for coronavirus disease 2019 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with reverse-transcription polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrollment and daily nasopharyngeal/throat swabs (NTSs) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals. Results Between 10 March and 4 April 2020, 14 000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13 (43%) never had symptoms and 17 (57%) were symptomatic. Seventeen (57%) participants imported cases. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS collected at enrollment (8/13 [62%] vs 17/17 [100%] ; P = .02). SARS-CoV-2 RNA was detected in 20 of 27 (74%) available saliva samples (7 of 11 [64%] in the asymptomatic group and 13 of 16 [81%] in the symptomatic group; P = .56). Analysis of RT-PCR positivity probability showed that asymptomatic participants had faster viral clearance than symptomatic participants (P  & lt; .001 for difference over the first 19 days). This difference was most pronounced during the first week of follow-up. Two of the asymptomatic individuals appeared to transmit SARS-CoV-2 to 4 contacts. Conclusions Asymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTSs. The NTS viral loads fall faster in asymptomatic individuals, but these individuals appear able to transmit the virus to others.
    Type of Medium: Online Resource
    ISSN: 1058-4838 , 1537-6591
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2002229-3
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  • 9
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2014
    In:  IEEE Transactions on Industrial Electronics Vol. 61, No. 6 ( 2014-06), p. 2922-2932
    In: IEEE Transactions on Industrial Electronics, Institute of Electrical and Electronics Engineers (IEEE), Vol. 61, No. 6 ( 2014-06), p. 2922-2932
    Type of Medium: Online Resource
    ISSN: 0278-0046 , 1557-9948
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2014
    detail.hit.zdb_id: 2027527-4
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  • 10
    Online Resource
    Online Resource
    International Journal of Medical Science and Health Research ; 2022
    In:  International Journal of Medical Science and Health Research Vol. 06, No. 03 ( 2022), p. 58-72
    In: International Journal of Medical Science and Health Research, International Journal of Medical Science and Health Research, Vol. 06, No. 03 ( 2022), p. 58-72
    Abstract: Background: The presence of acute kidney injury in the setting of acute heart failure (AHF) or acute decompensated heart failure (ADHF) is very common occurrence and was termed cardiorenal syndrome 1 (CRS1). Neutrophil gelatinase-associated lipocalin (NGAL) in the blood and urine is one of the earliest biomarkers of acute kidney injury due to ischemia or renal toxicity. Cystatin C is early marker of renal dysfunction. NT-pro BNP is valuable in the diagnosis, prognosis and treatment of acute and chronic heart failure. This study was aimed to evaluate the diagnostic efficacy of the combination of plasma NGAL, Cystatin C and NTproBNP in diagnosis of CRS1. Methods: there were 139 patients with AHF or ADHF in the department of Cardiovascular resuscitation and Interventional cardiology at Ho Chi Minh City 115People Hospital from November 2018 to May 2019. This was a prospective cohort study. Results: there were 48 cases (rate 34.5%) with CRS1, mean age 66.12 ± 15.77, men accounted for 50.4%. There were no significant differences of vital signs on admission, diagnosis, type of heart failure between CRS1 and Non-CRS1 groups. The urea, creatinin on first day (creatininD1) and third day (creatininD3), NT-pro BNP, Cystatin C, NGAL levels were higher in the group with CRS1 than Non-CRS1, the difference was statistically significant p 353.23 ng/ml, Area Under Curve (AUC)was 0.732 (95% CI 0.65-0.80, p 1.81 mg/dl, AUC was 0.787 (95% CI 0.71-0.85, p 〈 0.001), sensitivity 53.19%, specificity 77.17%, positive predictive value 54.3%, negative predictive value 76.3%.Combined three biomarker plasma NGAL, Cystatin C and NT proBNP, the specificity of the diagnosis was the highest 95.6%, the positive predictive value was the highest 84.62% in diagnosing CRS1. Conclusions: The combined plasma NGAL, Cystatin C and NT-pro BNP is high value in the diagnosis of CRS1 in patients with AHF or ADHF.
    Type of Medium: Online Resource
    ISSN: 2581-3366
    URL: Issue
    Language: Unknown
    Publisher: International Journal of Medical Science and Health Research
    Publication Date: 2022
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