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  • 1
    Online Resource
    Online Resource
    Fibronectin-Grafted Titanium Dental Implants: An In Vivo Study
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-11
    Abstract: Modification of the physiochemical properties of titanium surfaces using glow discharge plasma (GDP) and fibronectin coating has been shown to enhance the surface hydrophilicity, surface roughness, cell adhesion, migration, and proliferation. This in vivo study aimed to evaluate the bone integration efficacy of a biologically modified implant surface. Two different surface-modified implants (Ar-GDP and GDP-fib) were placed in the mandibular premolar area of six beagle dogs for 2–8 weeks. Three techniques [histologic evaluation, resonance frequency analysis (RFA), and microcomputed tomography (micro-CT) evaluation] were used to detect the implant stability and bone-implant contact. The implant stability quotient values of GDP-fib implants were significantly greater than the Ar-GDP implants at 2 and 4 weeks ( P 〈 0.01 ). The bone volume/total volume ratio of GDP-fib implants was greater than the Ar-GDP implants in micro-CT evaluation. A high positive correlation was observed between RFA and micro-CT measurements. At 2 weeks, osteoblasts were seen to line the implant surface, and multinuclear osteoclasts could be seen on the surface of old parent bone. After 8 weeks, a majority of the space in the wound chamber appeared to be replaced by bone. Enhancement of the stability of biologically modified implants was proved by the results of RFA, micro-CT, and histological analysis. This enhanced stability may help fasten treatment and be clinically beneficial.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/2414809
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Calcium Phosphate Nanoclusters for the Repair of Tooth Enamel Erosion
    MDPI AG ; 2022
    In:  Nanomaterials Vol. 12, No. 12 ( 2022-06-10), p. 1997-
    Details
    In: Nanomaterials, MDPI AG, Vol. 12, No. 12 ( 2022-06-10), p. 1997-
    Abstract: The artificial repair of tooth enamel is still an urgent requirement because it has a complicated and well-arranged structure. Herein, calcium phosphate nanoclusters (CaP NCs) were synthesized, via a facile approach, for application in the repair of tooth enamel erosion. Structural and optical characterizations validated the successful preparation of spherical CaP NCs, with an average size of 2.1 ± 0.11 nm. By evaporating the ethanol and triethylamine (TEA) solvents, pure CaP was produced, which was further used to repair the tooth enamel. Simulated caries lesions were achieved via phosphoric acid etching to cause damage to enamel rods. After repair, the damaged enamel rods were directly covered with CaP. According to microhardness testing, after repair with CaP NCs, the hardness value of the tooth enamel with acid etching increased to a similar level to that of normal tooth enamel. The results of the microhardness test indicated that CaP NCs revealed great potential for repairing tooth enamel erosion. Our work demonstrates a promising potential for treating the early stage of tooth erosion with CaP NCs. Based on these findings, we believe that stable CaP NCs can be employed as a precursor for the tunable, effective repair of tooth enamel in the near future.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano12121997
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662255-5
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  • 3
    Online Resource
    Online Resource
    3D pore-interconnected calcium phosphate bone blocks for bone tissue engineering
    Elsevier BV ; 2020
    In:  Ceramics International Vol. 46, No. 10 ( 2020-07), p. 16465-16471
    Details
    In: Ceramics International, Elsevier BV, Vol. 46, No. 10 ( 2020-07), p. 16465-16471
    Type of Medium: Online Resource
    ISSN: 0272-8842
    URL: Article
    DOI: 10.1016/j.ceramint.2020.03.211
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2018052-4
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  • 4
    Online Resource
    Online Resource
    A Continuous Static‐Mixer‐Based Reactor for Preparing Calcium Phosphate Bioceramics
    Wiley ; 2016
    In:  International Journal of Applied Ceramic Technology Vol. 13, No. 1 ( 2016-01), p. 88-99
    Details
    In: International Journal of Applied Ceramic Technology, Wiley, Vol. 13, No. 1 ( 2016-01), p. 88-99
    Abstract: The common methods for synthesizing calcium phosphates include solid‐state reaction, hydrothermal, sol–gel, and wet precipitation. The purpose of this study was to prepare various calcium phosphate bioceramics through a continuous reactor equipped with a static mixer. The precursors, amorphous calcium phosphate ( ACP ), and poor crystal hydroxyapatite ( PC ‐ HA p) were prepared using calcium and phosphate ion‐containing solutions by adjusting the pH and the [Ca]/[P] input ratio. The phase transformation from precursors to HA p, alpha‐tricalcium phosphates (α‐ TCP ), beta‐tricalcium phosphate (β‐ TCP ), or biphasic calcium phosphate ( BCP ) was dependent on the sintering temperature.
    Type of Medium: Online Resource
    ISSN: 1546-542X , 1744-7402
    URL: Issue
    URL: Article
    DOI: 10.1111/ijac.2016.13.issue-1
    DOI: 10.1111/ijac.12437
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2167226-X
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  • 5
    Online Resource
    Online Resource
    Porcine Collagen–Bone Composite Induced Osteoblast Differentiation and Bone Regeneration In Vitro and In Vivo
    MDPI AG ; 2020
    In:  Polymers Vol. 12, No. 1 ( 2020-01-04), p. 93-
    Details
    In: Polymers, MDPI AG, Vol. 12, No. 1 ( 2020-01-04), p. 93-
    Abstract: Due to autogenous bone limitations, some substitute bone grafts were developed. Collagenated porcine graft (CPG) is able to regenerate new bone, although the number of studies is insufficient, highlighting the need for future studies to better understand the biomaterial. In order to understand better CPG′s possible dental guided bone regeneration indications, the aim of this work was to determine CPG′s biological capacity to induce osteoblast differentiation in vitro and guided bone regeneration in vivo, whilst being compared with commercial hydroxyapatite and beta tricalcium phosphate (HA/β-TCP) and porcine graft alone. Cell cytotoxicity (WST-1), alkaline phosphatase activity (ALP), and real-time polymerase chain reaction (qPCR) were assessed in vitro. Critical size defects of New Zealand white rabbits were used for the in vivo part, with critical size defect closures and histological analyses. WST-1 and ALP indicated that CPG directly stimulated a greater proliferation and confluency of cells with osteoblastic differentiation in vitro. Gene sequencing indicated stable bone formation markers, decreased resorption makers, and bone remodeling coupling factors, making the transition from osteoclast to osteoblast expression at the end of seven days. CPG resulted in the highest new bone regeneration by osteoconduction in critical size defects of rabbit calvaria at eight weeks. Nonetheless, all biomaterials achieved nearly complete calvaria defect closure. CPG was found to be osteoconductive, like porcine graft and HA/β-TCP, but with higher new bone formation in critical size defects of rabbit calvaria at eight weeks. CPG can be used for different dental guided bone regeneration procedures; however, further studies are necessary.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym12010093
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2527146-5
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  • 6
    Online Resource
    Online Resource
    Cigarette Smoking Aggravates the Activity of Periodontal Disease by Disrupting Redox Homeostasis- An Observational Study
    Springer Science and Business Media LLC ; 2018
    In:  Scientific Reports Vol. 8, No. 1 ( 2018-07-23)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-07-23)
    Abstract: The aim of this study was to evaluate the associations between cigarette use and five salivary oxidative stress biomarkers, copper-zinc superoxide dismutase (Cu/Zn SOD), manganese superoxide dismutase (MnSOD), catalase, thioredoxin-1 (TRX1), and peroxiredoxin-2 (PRX2), to assess the effectiveness of non-surgical periodontal therapy. Materials and Methods: This is an observational study,167 patients diagnosed with periodontitis were recruited. Both saliva samples and clinical measurements (plaque index (PI), bleeding on probing (BOP), and pocket depth (PD)) were taken at baseline and after completing non-surgical periodontal therapy. The Levels of salivary biomarkers were determined using a MILLIPLEX ® MAP Human Oxidative Stress Magnetic Bead Panel kit. The overall reductions in PI and BOP were 31.56% and 42.16%, respectively. BOP reduction after treatment in female or male non-smokers was significantly higher than in male former smokers (p  〈  0.05). After completing non-surgical periodontal therapy, Cu/ZnSOD, MnSOD, catalase, and Prx2 significantly decreased. There was a significant interaction between smoking status and ΔCu/ZnSOD on PI and a significant interaction between smoking status and ΔCatalase on BOP. Conclusions: Cigarette smoking interferes with redox homeostasis in the body, alters antioxidants levels, and influences the periodontal disease activity.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-018-29163-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    Bone regeneration using a porcine bone substitute collagen composite in vitro and in vivo
    Springer Science and Business Media LLC ; 2018
    In:  Scientific Reports Vol. 8, No. 1 ( 2018-01-17)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-01-17)
    Abstract: The biocharacteristics of xenogeneic grafts make them a possible substitute for autogenous bone grafts in dental bone graft procedures. This study aimed to develop a novel porcine graft with collagen capable of generating new bone in bone defects via osteoconduction over 8 weeks of healing and to compare it with a porcine graft. The porcine collagen graft was made to undergo a cell viability test (MTT) and alkaline phosphatase assay (ALP). The surgical procedure was performed in 20 male adult New Zealand white rabbits. Four calvarial critical-size defects of 6 mm in diameter were prepared in each rabbit. The upper left defect was filled with a porcine graft of 500–1000 μm, the upper right with a porcine collagen graft, the lower left with hydroxyapatite/beta-tricalcium phosphate and the lower right served as the control without any filling material. The rabbits were divided and sacrificed at 2, 4, 6 and 8 weeks after surgery. Histological and micro-CT scan results showed that the performance of the porcine collagen graft is superior for regenerating new bone. Porcine collagen graft showed cell viability and osteoblast-like cell differentiation in vitro . The results indicate that porcine collagen graft is a potential bone substitute for clinical application.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-018-19629-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
    Online Resource
    Fabrication of Polylactic Acid/β-Tricalcium Phosphate FDM 3D Printing Fiber to Enhance Osteoblastic-Like Cell Performance
    Frontiers Media SA ; 2021
    In:  Frontiers in Materials Vol. 8 ( 2021-5-28)
    Details
    In: Frontiers in Materials, Frontiers Media SA, Vol. 8 ( 2021-5-28)
    Abstract: Guided-bone regeneration (GBR) is increasingly using three-dimensional (3D) printing by fused deposition modeling (FDM) to build the filaments used for treatment. Polylactic acid (PLA) and beta-tricalcium phosphate (β-TCP) are widely used as base materials in 3D printing, necessitating that they are studied together in the context of GBR treatment. This study sought to test and compare the properties and efficacy of different ratios of β-TCP and PLA used to make the 3D-printed filament material to find the most effective combination of materials for GBR treatment. Several ratios of PLA to β-TCP were tested, including PLA/β-TCP ratios of 95%/5% (PLA-5), 90%/10% (PLA-10), 85%/15% (PLA-15), and 80%/20% (PLA-20), and quantitative real-time polymerase chain reaction (qPCR) in vitro testing was done to characterize the material. After adding β-TCP to PLA, mechanical testing indicated that tensile and elongation strengths decreased, hardness was retained, and cell proliferation was promoted. The effect of PLA and β-TCP on increasing alkaline phosphatase (ALP) activity was significantly greater in a ratio of 10% β-TCP/90% PLA at 5 days ( p & lt; 0.05) than in any other ratios tested. This is supported by results from qPCR testing, which showed early osteoblast-like differentiation of DLX5, RUNX2, OPG, OC, and collagen type 1 (COL-1) expression levels similar to cells cultured on PLA-10. Our results demonstrated that 3D printing of filaments produced in a ratio of 90% PLA to 10% β-TCP was more effective for GBR than that of filaments produced only using PLA.
    Type of Medium: Online Resource
    ISSN: 2296-8016
    URL: Article
    DOI: 10.3389/fmats.2021.683706
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2759394-0
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  • 9
    Online Resource
    Online Resource
    Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
    Springer Science and Business Media LLC ; 2019
    In:  BMC Oral Health Vol. 19, No. 1 ( 2019-12)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2019-12)
    Type of Medium: Online Resource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-019-0877-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2091511-1
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  • 10
    Online Resource
    Online Resource
    A novel porcine collagen GTR membrane for treatment of Class II molar furcation involvement
    Walter de Gruyter GmbH ; 2014
    In:  Journal of Polymer Engineering Vol. 34, No. 3 ( 2014-05-1), p. 237-240
    Details
    In: Journal of Polymer Engineering, Walter de Gruyter GmbH, Vol. 34, No. 3 ( 2014-05-1), p. 237-240
    Abstract: Guided tissue regeneration (GTR) in the management of the periodontal furcation invasion is effective. Recent studies showed significant clinical improvement with different materials. The purpose of this study is to provide clinical evaluations of the bone repair potential of GTR combined with a novel porcine collagen membrane in the treatment of human molar Class II furcations. Fifty-one patients, 33 males and 18 females, with no systemic disease and a mean age of 49.1 years, participated in this study after phase I periodontal therapy. Probing depth, attachment loss and radiographic examination were recorded and analyzed before and after GTR therapy with collagen membrane. In the soft tissue measurement, the periodontal pocket (PD) depth was 5.283±0.283 mm before the surgery and improved to 2.631±0.147 mm at 9 months after surgery (p 〈 0.05). Attachment loss also showed similar results. The attachment level was 5.547±0.3 mm before the surgery, and 2.911±0.188 mm at 9 months after surgery (p 〈 0.05). According to the measurements the attachment gain was 2.636±0.168 mm after GTR surgery with porcine collagen membrane. According to this study, the porcine collagen membrane can perform with exceptional results in attachment level gain for the Class II periodontal furcation involvement.
    Type of Medium: Online Resource
    ISSN: 2191-0340 , 0334-6447
    URL: Article
    DOI: 10.1515/polyeng-2013-0209
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
    detail.hit.zdb_id: 2602430-5
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