In:
Turkish Journal of Biochemistry, Walter de Gruyter GmbH, Vol. 45, No. 1 ( 2020-01-15), p. 91-98
Abstract:
Cutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (β-catenin) proteins have an effect on cSCC. Materials and methods VDR, CaSR and β-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated. Results IHC staining density of VDR and β-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and β-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and β-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown. Conclusion The findings suggest that VDR and β-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and β-catenin together on cSCC.
Type of Medium:
Online Resource
ISSN:
1303-829X
,
0250-4685
DOI:
10.1515/tjb-2019-0434
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2020
detail.hit.zdb_id:
2244112-8
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